Sandbox/23
< Sandbox
| ' | Early Infection | Early Infection | Late Infection |
| System | Stage 1 (Localized) | Stage 2 (Disseminated) | Stage 3 (Persistent) |
| Skin | Erythema migrans | Secondary annular lesions | Acrodermatitis chronica atrophicans |
| Malar rash | Localized scleroderma-like lesions | ||
| Diffuse erythema or urticaria | |||
| Evanescent lesions | |||
| Lymphocytoma | |||
| Musculoskeletal | Migratory arthralgia | Prolonged arthritis attacks | |
| Brief arthritis attacks | Chronic arthritis | ||
| Myositis | Peripheral enthesopathy | ||
| Osteomyelitis | Periostitis or joint subluxations below acrodermatitis | ||
| Panniculitis | |||
| Neurologic | Meningitis | Chronic encephalomyelitis | |
| Cranial neuritis or Bell's palsy | Spastic parapareses | ||
| Motor or sensory radiculoneuritis | Ataxic gait | ||
| Encephalitis | Mental disorders | ||
| Mononeuritis multiplex | Chronic axonal polyradiculopathy | ||
| Pseudotumor cerebri | Dementia | ||
| Myelitis | |||
| Chorea | |||
| Cerebellar ataxia | |||
| Lymphatic | Regional lymphadenopathy | Regional or generalized lymphadenopathy | |
| Splenomegaly | |||
| Heart | Atrioventricular nodal block | ||
| Myopericarditis | |||
| Pancarditis | |||
| Eyes | Conjunctivitis | Keratitis | |
| Iritis | |||
| Choroiditis | |||
| Retinal hemorrhage or detachment | |||
| Panophthalmitis | |||
| Liver | Mild or recurrent hepatitis | ||
| Respiratory | Nonexudative sore throat | ||
| Nonproductive cough | |||
| Adult respiratory distress syndrome | |||
| Kidney | Microscopic hematuria or proteinuria | ||
| Genitourinary | Orchitis | ||
| Constitutional systems | Minor | Severe malaise and fatigue | Fatigue |