SYN3

Synapsin III
File:PBB Protein SYN3 image.jpg PDB rendering based on 2p0a.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2p0a​
Identifiers
Symbols	SYN3 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68320
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE SYN3 206322 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Synapsin III, also known as SYN3, is a human gene.

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in six transcript variants; however, only two variants have been fully described.

Further reading

• Kao HT, Porton B, Czernik AJ; et al. (1998). "A third member of the synapsin gene family". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4667–72. PMID 9539796.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hosaka M, Südhof TC (1999). "Homo- and heterodimerization of synapsins". J. Biol. Chem. 274 (24): 16747–53. PMID 10358015.
• Kao HT, Porton B, Hilfiker S; et al. (2000). "Molecular evolution of the synapsin gene family". J. Exp. Zool. 285 (4): 360–77. PMID 10578110.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Porton B, Kao HT, Greengard P (1999). "Characterization of transcripts from the synapsin III gene locus". J. Neurochem. 73 (6): 2266–71. PMID 10582583.CS1 maint: Multiple names: authors list (link)
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsai MT, Hung CC, Tsai CY; et al. (2002). "Mutation analysis of synapsin III gene in schizophrenia". Am. J. Med. Genet. 114 (1): 79–83. PMID 11840510.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jaffrey SR, Benfenati F, Snowman AM; et al. (2002). "Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 3199–204. doi:10.1073/pnas.261705799. PMID 11867766.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Porton B, Ferreira A, DeLisi LE, Kao HT (2004). "A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia". Biol. Psychiatry. 55 (2): 118–25. PMID 14732590.CS1 maint: Multiple names: authors list (link)
• Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lachman HM, Stopkova P, Rafael MA, Saito T (2005). "Association of schizophrenia in African Americans to polymorphism in synapsin III gene". Psychiatr. Genet. 15 (2): 127–32. PMID 15900227.CS1 maint: Multiple names: authors list (link)
• Lachman HM, Stopkova P, Papolos DF; et al. (2006). "Analysis of synapsin III-196 promoter mutation in schizophrenia and bipolar disorder". Neuropsychobiology. 53 (2): 57–62. doi:10.1159/000091720. PMID 16511335.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Makkar R, Gomez L, Wigg KG; et al. (2007). "The gene for synapsin III and attention-deficit hyperactivity disorder". Psychiatr. Genet. 17 (2): 109–12. doi:10.1097/YPG.0b013e328012a0c6. PMID 17413450.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)