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{{Infobox_gene}}
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'''Synapsin-3''' is a [[protein]] that in humans is encoded by the ''SYN3'' [[gene]].<ref name="pmid9539796">{{cite journal | vauthors = Kao HT, Porton B, Czernik AJ, Feng J, Yiu G, Haring M, Benfenati F, Greengard P | title = A third member of the synapsin gene family | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 8 | pages = 4667–72 |date=May 1998 | pmid = 9539796 | pmc = 22548 | doi =10.1073/pnas.95.8.4667 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SYN3 synapsin III| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8224| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_SYN3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2p0a.
| PDB = {{PDB2|2p0a}}
| Name = Synapsin III
| HGNCid = 11496
| Symbol = SYN3
| AltSymbols =;
| OMIM = 602705
| ECnumber =
| Homologene = 68320
| MGIid = 1351334
| GeneAtlas_image1 = PBB_GE_SYN3_206322_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0030672 |text = synaptic vesicle membrane}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0007269 |text = neurotransmitter secretion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8224
    | Hs_Ensembl = ENSG00000185666
    | Hs_RefseqProtein = NP_003481
    | Hs_RefseqmRNA = NM_003490
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 31239679
    | Hs_GenLoc_end = 31732647
    | Hs_Uniprot = O14994
    | Mm_EntrezGene = 27204
    | Mm_Ensembl = ENSMUSG00000059602
    | Mm_RefseqmRNA = NM_013722
    | Mm_RefseqProtein = NP_038750
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 85485331
    | Mm_GenLoc_end = 85897088
    | Mm_Uniprot = Q3KN99
  }}
}}
'''Synapsin III''', also known as '''SYN3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SYN3 synapsin III| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8224| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in six transcript variants; however, only two variants have been fully described.<ref name="entrez">{{cite web | title = Entrez Gene: SYN3 synapsin III| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8224| accessdate = }}</ref>
| summary_text = This gene is a member of the [[synapsin]] gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The [[TIMP3]] gene is located within an intron of this gene and is transcribed in the opposite direction. [[Alternative splicing]] of this gene results in six transcript variants; however, only two variants have been fully described.<ref name="entrez">{{cite web | title = Entrez Gene: SYN3 synapsin III| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8224| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kao HT, Porton B, Czernik AJ, ''et al.'' |title=A third member of the synapsin gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 8 |pages= 4667-72 |year= 1998 |pmid= 9539796 |doi=  }}
*{{cite journal  | vauthors=Hosaka M, Südhof TC |title=Homo- and heterodimerization of synapsins. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16747–53 |year= 1999 |pmid= 10358015 |doi=10.1074/jbc.274.24.16747 }}
*{{cite journal  | author=Hosaka M, Südhof TC |title=Homo- and heterodimerization of synapsins. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16747-53 |year= 1999 |pmid= 10358015 |doi=  }}
*{{cite journal   |vauthors=Kao HT, Porton B, Hilfiker S, etal |title=Molecular evolution of the synapsin gene family. |journal=J. Exp. Zool. |volume=285 |issue= 4 |pages= 360–77 |year= 2000 |pmid= 10578110 |doi=10.1002/(SICI)1097-010X(19991215)285:4<360::AID-JEZ4>3.0.CO;2-3 }}
*{{cite journal | author=Kao HT, Porton B, Hilfiker S, ''et al.'' |title=Molecular evolution of the synapsin gene family. |journal=J. Exp. Zool. |volume=285 |issue= 4 |pages= 360-77 |year= 2000 |pmid= 10578110 |doi=  }}
*{{cite journal  | vauthors=Porton B, Kao HT, Greengard P |title=Characterization of transcripts from the synapsin III gene locus. |journal=J. Neurochem. |volume=73 |issue= 6 |pages= 2266–71 |year= 1999 |pmid= 10582583 |doi=10.1046/j.1471-4159.1999.0732266.x }}
*{{cite journal  | author=Porton B, Kao HT, Greengard P |title=Characterization of transcripts from the synapsin III gene locus. |journal=J. Neurochem. |volume=73 |issue= 6 |pages= 2266-71 |year= 1999 |pmid= 10582583 |doi=  }}
*{{cite journal   |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal   |vauthors=Tsai MT, Hung CC, Tsai CY, etal |title=Mutation analysis of synapsin III gene in schizophrenia. |journal=Am. J. Med. Genet. |volume=114 |issue= 1 |pages= 79–83 |year= 2002 |pmid= 11840510 |doi=10.1002/ajmg.10116 }}
*{{cite journal | author=Tsai MT, Hung CC, Tsai CY, ''et al.'' |title=Mutation analysis of synapsin III gene in schizophrenia. |journal=Am. J. Med. Genet. |volume=114 |issue= 1 |pages= 79-83 |year= 2002 |pmid= 11840510 |doi=  }}
*{{cite journal   |vauthors=Jaffrey SR, Benfenati F, Snowman AM, etal |title=Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 3199–204 |year= 2002 |pmid= 11867766 |doi= 10.1073/pnas.261705799 | pmc=122496 }}
*{{cite journal | author=Jaffrey SR, Benfenati F, Snowman AM, ''et al.'' |title=Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 3199-204 |year= 2002 |pmid= 11867766 |doi= 10.1073/pnas.261705799 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Porton B, Ferreira A, DeLisi LE, Kao HT |title=A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia. |journal=Biol. Psychiatry |volume=55 |issue= 2 |pages= 118–25 |year= 2004 |pmid= 14732590 |doi=10.1016/j.biopsych.2003.07.002 }}
*{{cite journal  | author=Porton B, Ferreira A, DeLisi LE, Kao HT |title=A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia. |journal=Biol. Psychiatry |volume=55 |issue= 2 |pages= 118-25 |year= 2004 |pmid= 14732590 |doi=  }}
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Lachman HM, Stopkova P, Rafael MA, Saito T |title=Association of schizophrenia in African Americans to polymorphism in synapsin III gene. |journal=Psychiatr. Genet. |volume=15 |issue= 2 |pages= 127–32 |year= 2005 |pmid= 15900227 |doi=10.1097/00041444-200506000-00009 }}
*{{cite journal  | author=Lachman HM, Stopkova P, Rafael MA, Saito T |title=Association of schizophrenia in African Americans to polymorphism in synapsin III gene. |journal=Psychiatr. Genet. |volume=15 |issue= 2 |pages= 127-32 |year= 2005 |pmid= 15900227 |doi=  }}
*{{cite journal   |vauthors=Lachman HM, Stopkova P, Papolos DF, etal |title=Analysis of synapsin III-196 promoter mutation in schizophrenia and bipolar disorder. |journal=Neuropsychobiology |volume=53 |issue= 2 |pages= 57–62 |year= 2006 |pmid= 16511335 |doi= 10.1159/000091720 }}
*{{cite journal | author=Lachman HM, Stopkova P, Papolos DF, ''et al.'' |title=Analysis of synapsin III-196 promoter mutation in schizophrenia and bipolar disorder. |journal=Neuropsychobiology |volume=53 |issue= 2 |pages= 57-62 |year= 2006 |pmid= 16511335 |doi= 10.1159/000091720 }}
*{{cite journal   |vauthors=Makkar R, Gomez L, Wigg KG, etal |title=The gene for synapsin III and attention-deficit hyperactivity disorder. |journal=Psychiatr. Genet. |volume=17 |issue= 2 |pages= 109–12 |year= 2007 |pmid= 17413450 |doi= 10.1097/YPG.0b013e328012a0c6 }}
*{{cite journal | author=Makkar R, Gomez L, Wigg KG, ''et al.'' |title=The gene for synapsin III and attention-deficit hyperactivity disorder. |journal=Psychiatr. Genet. |volume=17 |issue= 2 |pages= 109-12 |year= 2007 |pmid= 17413450 |doi= 10.1097/YPG.0b013e328012a0c6 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=8224}}
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{{Nerve tissue protein}}
[[Category:Biology of bipolar disorder]]


{{gene-22-stub}}
{{gene-22-stub}}
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Latest revision as of 07:22, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Synapsin-3 is a protein that in humans is encoded by the SYN3 gene.[1][2]

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in six transcript variants; however, only two variants have been fully described.[2]

References

  1. ↑ Kao HT, Porton B, Czernik AJ, Feng J, Yiu G, Haring M, Benfenati F, Greengard P (May 1998). "A third member of the synapsin gene family". Proc Natl Acad Sci U S A. 95 (8): 4667–72. doi:10.1073/pnas.95.8.4667. PMC 22548. PMID 9539796.
  2. ↑ 2.0 2.1 "Entrez Gene: SYN3 synapsin III".

Further reading



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