STRC

Stereocilin
Identifiers
Symbols	STRC ; DFNB16; MGC156147
External IDs	Template:OMIM5 Template:MGI HomoloGene: 15401
Gene ontology Biological process Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Stereocilin, also known as STRC, is a human gene.

This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness.

Further reading

• Bitner-Glindzicz M (2002). "Hereditary deafness and phenotyping in humans". Br. Med. Bull. 63: 73–94. PMID 12324385.
• Zody MC, Garber M, Sharpe T; et al. (2006). "Analysis of the DNA sequence and duplication history of human chromosome 15". Nature. 440 (7084): 671–5. doi:10.1038/nature04601. PMID 16572171.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jovine L, Park J, Wassarman PM (2003). "Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear". BMC Cell Biol. 3: 28. PMID 12445334.CS1 maint: Multiple names: authors list (link)
• Verpy E, Masmoudi S, Zwaenepoel I; et al. (2001). "Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus". Nat. Genet. 29 (3): 345–9. doi:10.1038/ng726. PMID 11687802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Villamar M, del Castillo I, Valle N; et al. (2000). "Deafness locus DFNB16 is located on chromosome 15q13-q21 within a 5-cM interval flanked by markers D15S994 and D15S132". Am. J. Hum. Genet. 64 (4): 1238–41. PMID 10090914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Campbell DA, McHale DP, Brown KA; et al. (1998). "A new locus for non-syndromal, autosomal recessive, sensorineural hearing loss (DFNB16) maps to human chromosome 15q21-q22". J. Med. Genet. 34 (12): 1015–7. PMID 9429146.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

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