SRA1

Steroid receptor RNA activator 1
Identifiers
Symbols	SRA1 ; MGC87674; SRA; SRAP; STRAA1; pp7684
External IDs	Template:OMIM5 Template:MGI HomoloGene: 11906
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SRA1 gnf1h06172 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Steroid receptor RNA activator 1, also known as SRA1, is a human gene.

This gene is involved in transcriptional coactivation by steroid receptors. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.

Further reading

• Lanz RB, McKenna NJ, Onate SA; et al. (1999). "A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex". Cell. 97 (1): 17–27. PMID 10199399.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leygue E, Dotzlaw H, Watson PH, Murphy LC (1999). "Expression of the steroid receptor RNA activator in human breast tumors". Cancer Res. 59 (17): 4190–3. PMID 10485452.CS1 maint: Multiple names: authors list (link)
• Murphy LC, Simon SL, Parkes A; et al. (2000). "Altered expression of estrogen receptor coregulators during human breast tumorigenesis". Cancer Res. 60 (22): 6266–71. PMID 11103781.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Watanabe M, Yanagisawa J, Kitagawa H; et al. (2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. PMID 11250900.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cavarretta IT, Mukopadhyay R, Lonard DM; et al. (2002). "Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation". Mol. Endocrinol. 16 (2): 253–70. PMID 11818499.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kucera T, Waltner-Law M, Scott DK; et al. (2002). "A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1". J. Biol. Chem. 277 (29): 26098–102. doi:10.1074/jbc.M204013200. PMID 12118039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueda T, Mawji NR, Bruchovsky N, Sadar MD (2002). "Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells". J. Biol. Chem. 277 (41): 38087–94. doi:10.1074/jbc.M203313200. PMID 12163482.CS1 maint: Multiple names: authors list (link)
• Lanz RB, Razani B, Goldberg AD, O'Malley BW (2003). "Distinct RNA motifs are important for coactivation of steroid hormone receptors by steroid receptor RNA activator (SRA)". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16081–6. doi:10.1073/pnas.192571399. PMID 12444263.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Emberley E, Huang GJ, Hamedani MK; et al. (2003). "Identification of new human coding steroid receptor RNA activator isoforms". Biochem. Biophys. Res. Commun. 301 (2): 509–15. PMID 12565891.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR (2003). "Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor". J. Mol. Biol. 331 (4): 815–28. PMID 12909012.CS1 maint: Multiple names: authors list (link)
• Deblois G, Giguère V (2003). "Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation". J. Steroid Biochem. Mol. Biol. 85 (2–5): 123–31. PMID 12943696.
• Lanz RB, Chua SS, Barron N; et al. (2003). "Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo". Mol. Cell. Biol. 23 (20): 7163–76. PMID 14517287.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fleming FJ, Hill AD, McDermott EW; et al. (2004). "Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer". J. Clin. Endocrinol. Metab. 89 (1): 375–83. PMID 14715875.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chooniedass-Kothari S, Emberley E, Hamedani MK; et al. (2004). "The steroid receptor RNA activator is the first functional RNA encoding a protein". FEBS Lett. 566 (1–3): 43–7. doi:10.1016/j.febslet.2004.03.104. PMID 15147866.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu B, Koenig RJ (2004). "An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation". J. Biol. Chem. 279 (32): 33051–6. doi:10.1074/jbc.M404930200. PMID 15180993.
• Zhao X, Patton JR, Davis SL; et al. (2004). "Regulation of nuclear receptor activity by a pseudouridine synthase through posttranscriptional modification of steroid receptor RNA activator". Mol. Cell. 15 (4): 549–58. doi:10.1016/j.molcel.2004.06.044. PMID 15327771.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coleman KM, Lam V, Jaber BM; et al. (2004). "SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity". Biochem. Biophys. Res. Commun. 323 (1): 332–8. doi:10.1016/j.bbrc.2004.08.090. PMID 15351741.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)