SPRED2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Sprouty-related, [[EVH1 domain]]-containing protein 2''' is a [[protein]] that in humans is encoded by the ''SPRED2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SPRED2 sprouty-related, EVH1 domain containing 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200734| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SPRED2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2jp2.
| PDB = {{PDB2|2jp2}}
| Name = Sprouty-related, EVH1 domain containing 2
| HGNCid = 17722
| Symbol = SPRED2
| AltSymbols =; FLJ21897; FLJ31917; MGC163164; Spred-2
| OMIM = 609292
| ECnumber = 
| Homologene = 24918
| MGIid = 2150019
| GeneAtlas_image1 = PBB_GE_SPRED2_212458_at_tn.png
| GeneAtlas_image2 = PBB_GE_SPRED2_212466_at_tn.png
| Function = {{GNF_GO|id=GO:0005173 |text = stem cell factor receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000188 |text = inactivation of MAPK activity}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009966 |text = regulation of signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 200734
    | Hs_Ensembl = ENSG00000198369
    | Hs_RefseqProtein = NP_861449
    | Hs_RefseqmRNA = NM_181784
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 65391492
    | Hs_GenLoc_end = 65512815
    | Hs_Uniprot = Q7Z698
    | Mm_EntrezGene = 114716
    | Mm_Ensembl = ENSMUSG00000045671
    | Mm_RefseqmRNA = NM_033523
    | Mm_RefseqProtein = NP_277058
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 19824445
    | Mm_GenLoc_end = 19922600
    | Mm_Uniprot = Q924S7
  }}
}}
'''Sprouty-related, EVH1 domain containing 2''', also known as '''SPRED2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SPRED2 sprouty-related, EVH1 domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200734| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
SPRED2 is a member of the Sprouty (see [[SPRY1]])/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see [[MAPK1]]<ref name="entrez"/>).
{{PBB_Summary
| section_title =
| summary_text = SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SPRED2 sprouty-related, EVH1 domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200734| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
| citations =
*{{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal   |vauthors=Wakioka T, Sasaki A, Kato R, etal |title=Spred is a Sprouty-related suppressor of Ras signalling. |journal=Nature |volume=412 |issue= 6847 |pages= 647–51 |year= 2001 |pmid= 11493923 |doi= 10.1038/35088082 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Wakioka T, Sasaki A, Kato R, ''et al.'' |title=Spred is a Sprouty-related suppressor of Ras signalling. |journal=Nature |volume=412 |issue= 6847 |pages= 647-51 |year= 2001 |pmid= 11493923 |doi= 10.1038/35088082 }}
*{{cite journal   |vauthors=Kato R, Nonami A, Taketomi T, etal |title=Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. |journal=Biochem. Biophys. Res. Commun. |volume=302 |issue= 4 |pages= 767–72 |year= 2003 |pmid= 12646235 |doi=10.1016/S0006-291X(03)00259-6 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Kato R, Nonami A, Taketomi T, ''et al.'' |title=Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. |journal=Biochem. Biophys. Res. Commun. |volume=302 |issue= 4 |pages= 767-72 |year= 2003 |pmid= 12646235 |doi=  }}
*{{cite journal   |vauthors=Nobuhisa I, Kato R, Inoue H, etal |title=Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation. |journal=J. Exp. Med. |volume=199 |issue= 5 |pages= 737–42 |year= 2004 |pmid= 14981116 |doi= 10.1084/jem.20030830 | pmc=2213301 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Miyoshi K, Wakioka T, Nishinakamura H, etal |title=The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization. |journal=Oncogene |volume=23 |issue= 33 |pages= 5567–76 |year= 2004 |pmid= 15184877 |doi= 10.1038/sj.onc.1207759 }}
*{{cite journal | author=Nobuhisa I, Kato R, Inoue H, ''et al.'' |title=Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation. |journal=J. Exp. Med. |volume=199 |issue= 5 |pages= 737-42 |year= 2004 |pmid= 14981116 |doi= 10.1084/jem.20030830 }}
*{{cite journal   |vauthors=Zimmermann J, Jarchau T, Walter U, etal |title=1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain. |journal=J. Biomol. NMR |volume=29 |issue= 3 |pages= 435–6 |year= 2005 |pmid= 15213456 |doi= 10.1023/B:JNMR.0000032526.17586.8c }}
*{{cite journal | author=Miyoshi K, Wakioka T, Nishinakamura H, ''et al.'' |title=The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization. |journal=Oncogene |volume=23 |issue= 33 |pages= 5567-76 |year= 2004 |pmid= 15184877 |doi= 10.1038/sj.onc.1207759 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Zimmermann J, Jarchau T, Walter U, ''et al.'' |title=1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain. |journal=J. Biomol. NMR |volume=29 |issue= 3 |pages= 435-6 |year= 2005 |pmid= 15213456 |doi= 10.1023/B:JNMR.0000032526.17586.8c }}
*{{cite journal   |vauthors=Engelhardt CM, Bundschu K, Messerschmitt M, etal |title=Expression and subcellular localization of Spred proteins in mouse and human tissues. |journal=Histochem. Cell Biol. |volume=122 |issue= 6 |pages= 527–38 |year= 2005 |pmid= 15580519 |doi= 10.1007/s00418-004-0725-6 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=King JA, Straffon AF, D'Abaco GM, etal |title=Distinct requirements for the Sprouty domain for functional activity of Spred proteins. |journal=Biochem. J. |volume=388 |issue= Pt 2 |pages= 445–54 |year= 2005 |pmid= 15683364 |doi= 10.1042/BJ20041284 | pmc=1138951 }}
*{{cite journal | author=Engelhardt CM, Bundschu K, Messerschmitt M, ''et al.'' |title=Expression and subcellular localization of Spred proteins in mouse and human tissues. |journal=Histochem. Cell Biol. |volume=122 |issue= 6 |pages= 527-38 |year= 2005 |pmid= 15580519 |doi= 10.1007/s00418-004-0725-6 }}
*{{cite journal   |vauthors=Bundschu K, Knobeloch KP, Ullrich M, etal |title=Gene disruption of Spred-2 causes dwarfism. |journal=J. Biol. Chem. |volume=280 |issue= 31 |pages= 28572–80 |year= 2005 |pmid= 15946934 |doi= 10.1074/jbc.M503640200 }}
*{{cite journal | author=King JA, Straffon AF, D'Abaco GM, ''et al.'' |title=Distinct requirements for the Sprouty domain for functional activity of Spred proteins. |journal=Biochem. J. |volume=388 |issue= Pt 2 |pages= 445-54 |year= 2005 |pmid= 15683364 |doi= 10.1042/BJ20041284 }}
*{{cite journal   |vauthors=Yoshida T, Hisamoto T, Akiba J, etal |title=Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors. |journal=Oncogene |volume=25 |issue= 45 |pages= 6056–66 |year= 2006 |pmid= 16652141 |doi= 10.1038/sj.onc.1209635 }}
*{{cite journal | author=Bundschu K, Knobeloch KP, Ullrich M, ''et al.'' |title=Gene disruption of Spred-2 causes dwarfism. |journal=J. Biol. Chem. |volume=280 |issue= 31 |pages= 28572-80 |year= 2005 |pmid= 15946934 |doi= 10.1074/jbc.M503640200 }}
*{{cite journal   |vauthors=Lock P, I ST, Straffon AF, etal |title=Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. |journal=Biochem. Biophys. Res. Commun. |volume=351 |issue= 4 |pages= 1018–23 |year= 2007 |pmid= 17094949 |doi= 10.1016/j.bbrc.2006.10.150 }}
*{{cite journal | author=Yoshida T, Hisamoto T, Akiba J, ''et al.'' |title=Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors. |journal=Oncogene |volume=25 |issue= 45 |pages= 6056-66 |year= 2006 |pmid= 16652141 |doi= 10.1038/sj.onc.1209635 }}
*{{cite journal | author=Lock P, I ST, Straffon AF, ''et al.'' |title=Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. |journal=Biochem. Biophys. Res. Commun. |volume=351 |issue= 4 |pages= 1018-23 |year= 2007 |pmid= 17094949 |doi= 10.1016/j.bbrc.2006.10.150 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=legius  GeneReviews/NIH/NCBI/UW entry on Legius syndrome SPRED1 Sprouty-related, EVH1 domain-containing protein 1]
 
{{PDB Gallery|geneid=200734}}
 
[[Category:SPR domain]]
[[Category:EVH1 domain]]
[[Category:Human proteins]]
 
 
{{gene-2-stub}}

Latest revision as of 06:56, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.[1]

Function

SPRED2 is a member of the Sprouty (see SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1[1]).

References

  1. ↑ 1.0 1.1 "Entrez Gene: SPRED2 sprouty-related, EVH1 domain containing 2".

Further reading

External links


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