SOCS7: Difference between revisions

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{{Infobox_gene}}
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'''Suppressor of cytokine signaling 7''' is a [[protein]] that in humans is encoded by the ''SOCS7'' [[gene]].<ref name="pmid9344857">{{cite journal | vauthors = Matuoka K, Miki H, Takahashi K, Takenawa T | title = A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs | journal = Biochemical and Biophysical Research Communications | volume = 239 | issue = 2 | pages = 488–92 | date = Oct 1997 | pmid = 9344857 | pmc =  | doi = 10.1006/bbrc.1997.7492 }}</ref><ref name="pmid12076535">{{cite journal | vauthors = Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ | title = The SOCS box: a tale of destruction and degradation | journal = Trends in Biochemical Sciences | volume = 27 | issue = 5 | pages = 235–41 | date = May 2002 | pmid = 12076535 | pmc =  | doi = 10.1016/S0968-0004(02)02085-6 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SOCS7 suppressor of cytokine signaling 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30837| accessdate = }}</ref>
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==Model organisms==
{{GNF_Protein_box
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: right;" |
| image =
|+ ''Socs7'' knockout mouse phenotype
| image_source =
|-
| PDB =  
! Characteristic!! Phenotype
| Name = Suppressor of cytokine signaling 7
| HGNCid = 29846
| Symbol = SOCS7
| AltSymbols =; NAP4
| OMIM = 608788
| ECnumber = 
| Homologene = 16331
| MGIid = 2651588
| GeneAtlas_image1 = PBB_GE_SOCS7_214015_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0017124 |text = SH3 domain binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0008286 |text = insulin receptor signaling pathway}} {{GNF_GO|id=GO:0009968 |text = negative regulation of signal transduction}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}} {{GNF_GO|id=GO:0045444 |text = fat cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 30837
    | Hs_Ensembl = ENSG00000174111
    | Hs_RefseqProtein = XP_941665
    | Hs_RefseqmRNA = XM_936572
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 33761531
    | Hs_GenLoc_end = 33809541
    | Hs_Uniprot = O14512
    | Mm_EntrezGene = 192157
    | Mm_Ensembl = ENSMUSG00000038485
    | Mm_RefseqmRNA = XM_993570
    | Mm_RefseqProtein = XP_998664
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 97178641
    | Mm_GenLoc_end = 97214632
    | Mm_Uniprot = Q8VHQ2
  }}
}}
'''Suppressor of cytokine signaling 7''', also known as '''SOCS7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SOCS7 suppressor of cytokine signaling 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30837| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
|-
{{PBB_Summary
| [[Homozygote]] viability || bgcolor="#488ED3"|Normal
| section_title =  
|-
| summary_text =  
| Fertility || bgcolor="#488ED3"|Normal
}}
|-
| Body weight || bgcolor="#488ED3"|Normal
|-
| [[Open Field (animal test)|Anxiety]] || bgcolor="#488ED3"|Normal
|-
| Neurological assessment || bgcolor="#488ED3"|Normal
|-
| Grip strength || bgcolor="#488ED3"|Normal
|-
| [[Hot plate test|Hot plate]] || bgcolor="#488ED3"|Normal
|-
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
|-
| Body temperature || bgcolor="#C40000"|Abnormal<ref name="Body temperature">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBAJ/stress-induced-hyperthermia/ |title=Body temperature data for Socs7 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| Eye morphology || bgcolor="#488ED3"|Normal
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
|-
| [[Haematology]] || bgcolor="#488ED3"|Normal
|-
| [[Peripheral blood lymphocyte]]s || bgcolor="#488ED3"|Normal
|-
| [[Micronucleus test]] || bgcolor="#488ED3"|Normal
|-
| Heart weight || bgcolor="#488ED3"|Normal
|-
| Tail epidermis wholemount || bgcolor="#488ED3"|Normal
|-
| Skin Histopathology || bgcolor="#488ED3"|Normal
|-
| Brain histopathology || bgcolor="#488ED3"|Normal
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Salmonella'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBAJ/salmonella-challenge/ |title=''Salmonella'' infection data for Socs7 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| ''[[Citrobacter]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Citrobacter'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBAJ/citrobacter-challenge/ |title=''Citrobacter'' infection data for Socs7 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| colspan=2; style="text-align: center;" | All tests and analysis from<ref name="mgp_reference">{{cite journal | doi = 10.1111/j.1755-3768.2010.4142.x | title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice | year = 2010 | author = Gerdin AK | journal = Acta Ophthalmologica | volume = 88 | pages =  925–7 }}</ref><ref>[http://www.sanger.ac.uk/mouseportal/ Mouse Resources Portal], Wellcome Trust Sanger Institute.</ref>
|}
[[Model organism]]s have been used in the study of SOCS7 function. A conditional [[knockout mouse]] line, called ''Socs7<sup>tm1a(EUCOMM)Wtsi</sup>''<ref name="allele_ref">{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Socs7 |title=International Knockout Mouse Consortium}}</ref><ref name="mgi_allele_ref">{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432554 |title=Mouse Genome Informatics}}</ref> was generated as part of the [[International Knockout Mouse Consortium]] program—a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–342 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref>


==References==
Male and female animals underwent a standardized [[phenotypic screen]] to determine the effects of deletion.<ref name="mgp_reference" /><ref name="pmid21722353">{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }}</ref> Twenty five tests were carried out on [[mutant]] mice and one significant abnormality was observed: homozygous mutant males showed a decreased response to stress-induced [[hyperthermia]].<ref name="mgp_reference" />
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
SOCS7 has been shown to [[Protein-protein interaction|interact]] with [[NCK1]].<ref name=pmid9344857 />
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Cooney RN | title = Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway | journal = Shock | volume = 17 | issue = 2 | pages = 83–90 | date = Feb 2002 | pmid = 11837794 | doi = 10.1097/00024382-200202000-00001 }}
| citations =
* {{cite journal | vauthors = Wormald S, Hilton DJ | title = Inhibitors of cytokine signal transduction | journal = The Journal of Biological Chemistry | volume = 279 | issue = 2 | pages = 821–4 | date = Jan 2004 | pmid = 14607831 | doi = 10.1074/jbc.R300030200 }}
*{{cite journal | author=Cooney RN |title=Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway. |journal=Shock |volume=17 |issue= 2 |pages= 83-90 |year= 2002 |pmid= 11837794 |doi= }}
* {{cite journal | vauthors = Fujimoto M, Naka T | title = Regulation of cytokine signaling by SOCS family molecules | journal = Trends in Immunology | volume = 24 | issue = 12 | pages = 659–66 | date = Dec 2003 | pmid = 14644140 | doi = 10.1016/j.it.2003.10.008 }}
*{{cite journal  | author=Kile BT, Schulman BA, Alexander WS, ''et al.'' |title=The SOCS box: a tale of destruction and degradation. |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235-41 |year= 2002 |pmid= 12076535 |doi=  }}
* {{cite journal | vauthors = Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA | title = Twenty proteins containing a C-terminal SOCS box form five structural classes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 1 | pages = 114–9 | date = Jan 1998 | pmid = 9419338 | pmc = 18144 | doi = 10.1073/pnas.95.1.114 }}
*{{cite journal | author=Wormald S, Hilton DJ |title=Inhibitors of cytokine signal transduction. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 821-4 |year= 2004 |pmid= 14607831 |doi= 10.1074/jbc.R300030200 }}
* {{cite journal | vauthors = Dogusan Z, Hooghe-Peters EL, Berus D, Velkeniers B, Hooghe R | title = Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines | journal = Journal of Neuroimmunology | volume = 109 | issue = 1 | pages = 34–9 | date = Sep 2000 | pmid = 10969179 | doi = 10.1016/S0165-5728(00)00300-3 }}
*{{cite journal | author=Fujimoto M, Naka T |title=Regulation of cytokine signaling by SOCS family molecules. |journal=Trends Immunol. |volume=24 |issue= 12 |pages= 659-66 |year= 2004 |pmid= 14644140 |doi= }}
* {{cite journal | vauthors = Krebs DL, Uren RT, Metcalf D, Rakar S, Zhang JG, Starr R, De Souza DP, Hanzinikolas K, Eyles J, Connolly LM, Simpson RJ, Nicola NA, Nicholson SE, Baca M, Hilton DJ, Alexander WS | title = SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation | journal = Molecular and Cellular Biology | volume = 22 | issue = 13 | pages = 4567–78 | date = Jul 2002 | pmid = 12052866 | pmc = 133908 | doi = 10.1128/MCB.22.13.4567-4578.2002 }}
*{{cite journal  | author=Matuoka K, Miki H, Takahashi K, Takenawa T |title=A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 488-92 |year= 1997 |pmid= 9344857 |doi= 10.1006/bbrc.1997.7492 }}
* {{cite journal | vauthors = Martens N, Wery M, Wang P, Braet F, Gertler A, Hooghe R, Vandenhaute J, Hooghe-Peters EL | title = The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin | journal = Experimental Cell Research | volume = 298 | issue = 1 | pages = 239–48 | date = Aug 2004 | pmid = 15242778 | doi = 10.1016/j.yexcr.2004.04.002 }}
*{{cite journal | author=Hilton DJ, Richardson RT, Alexander WS, ''et al.'' |title=Twenty proteins containing a C-terminal SOCS box form five structural classes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 1 |pages= 114-9 |year= 1998 |pmid= 9419338 |doi= }}
* {{cite journal | vauthors = Martens N, Uzan G, Wery M, Hooghe R, Hooghe-Peters EL, Gertler A | title = Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation | journal = The Journal of Biological Chemistry | volume = 280 | issue = 14 | pages = 13817–23 | date = Apr 2005 | pmid = 15677474 | doi = 10.1074/jbc.M411596200 }}
*{{cite journal | author=Dogusan Z, Hooghe-Peters EL, Berus D, ''et al.'' |title=Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines. |journal=J. Neuroimmunol. |volume=109 |issue= 1 |pages= 34-9 |year= 2000 |pmid= 10969179 |doi= }}
* {{cite journal | vauthors = Banks AS, Li J, McKeag L, Hribal ML, Kashiwada M, Accili D, Rothman PB | title = Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans | journal = The Journal of Clinical Investigation | volume = 115 | issue = 9 | pages = 2462–71 | date = Sep 2005 | pmid = 16127460 | pmc = 1190369 | doi = 10.1172/JCI23853 }}
*{{cite journal | author=Krebs DL, Uren RT, Metcalf D, ''et al.'' |title=SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4567-78 |year= 2002 |pmid= 12052866 |doi=  }}
* {{cite journal | vauthors = Kremer BE, Adang LA, Macara IG | title = Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7 | journal = Cell | volume = 130 | issue = 5 | pages = 837–50 | date = Sep 2007 | pmid = 17803907 | pmc = 2085444 | doi = 10.1016/j.cell.2007.06.053 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Martens N, Wery M, Wang P, ''et al.'' |title=The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. |journal=Exp. Cell Res. |volume=298 |issue= 1 |pages= 239-48 |year= 2004 |pmid= 15242778 |doi= 10.1016/j.yexcr.2004.04.002 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Martens N, Uzan G, Wery M, ''et al.'' |title=Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13817-23 |year= 2005 |pmid= 15677474 |doi= 10.1074/jbc.M411596200 }}
*{{cite journal | author=Banks AS, Li J, McKeag L, ''et al.'' |title=Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. |journal=J. Clin. Invest. |volume=115 |issue= 9 |pages= 2462-71 |year= 2005 |pmid= 16127460 |doi= 10.1172/JCI23853 }}
*{{cite journal | author=Zody MC, Garber M, Adams DJ, ''et al.'' |title=DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |journal=Nature |volume=440 |issue= 7087 |pages= 1045-9 |year= 2006 |pmid= 16625196 |doi= 10.1038/nature04689 }}
*{{cite journal  | author=Kremer BE, Adang LA, Macara IG |title=Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. |journal=Cell |volume=130 |issue= 5 |pages= 837-50 |year= 2007 |pmid= 17803907 |doi= 10.1016/j.cell.2007.06.053 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{JAK-STAT signaling pathway}}
{{WikiDoc Sources}}
 
[[Category:Genes mutated in mice]]
 
 
{{gene-17-stub}}

Latest revision as of 06:48, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.[1][2][3]

Model organisms

Model organisms have been used in the study of SOCS7 function. A conditional knockout mouse line, called Socs7tm1a(EUCOMM)Wtsi[9][10] was generated as part of the International Knockout Mouse Consortium program—a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[11][12][13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty five tests were carried out on mutant mice and one significant abnormality was observed: homozygous mutant males showed a decreased response to stress-induced hyperthermia.[7]

Interactions

SOCS7 has been shown to interact with NCK1.[1]

References

  1. ↑ 1.0 1.1 Matuoka K, Miki H, Takahashi K, Takenawa T (Oct 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications. 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857.
  2. ↑ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
  3. ↑ "Entrez Gene: SOCS7 suppressor of cytokine signaling 7".
  4. ↑ "Body temperature data for Socs7". Wellcome Trust Sanger Institute.
  5. ↑ "Salmonella infection data for Socs7". Wellcome Trust Sanger Institute.
  6. ↑ "Citrobacter infection data for Socs7". Wellcome Trust Sanger Institute.
  7. ↑ 7.0 7.1 7.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  8. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  9. ↑ "International Knockout Mouse Consortium".
  10. ↑ "Mouse Genome Informatics".
  11. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  12. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  13. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  14. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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