SMURF2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''E3 ubiquitin-protein ligase SMURF2''' is an [[enzyme]] that in humans is encoded by the ''SMURF2'' [[gene]].<ref name="pmid11016919">{{cite journal | vauthors = Lin X, Liang M, Feng XH | title = Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling | journal = The Journal of Biological Chemistry | volume = 275 | issue = 47 | pages = 36818-22 | date = Nov 2000 | pmid = 11016919 | pmc =  | doi = 10.1074/jbc.C000580200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64750| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_SMURF2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1zvd.
| PDB = {{PDB2|1zvd}}, {{PDB2|2djy}}
| Name = SMAD specific E3 ubiquitin protein ligase 2
| HGNCid = 16809
| Symbol = SMURF2
| AltSymbols =; DKFZp686F0270; MGC138150
| OMIM = 605532
| ECnumber = 
| Homologene = 41490
| MGIid = 1913563
| GeneAtlas_image1 = PBB_GE_SMURF2_205596_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0017015 |text = regulation of transforming growth factor beta receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64750
    | Hs_Ensembl = ENSG00000108854
    | Hs_RefseqProtein = NP_073576
    | Hs_RefseqmRNA = NM_022739
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 59971197
    | Hs_GenLoc_end = 60088848
    | Hs_Uniprot = Q9HAU4
    | Mm_EntrezGene = 66313
    | Mm_Ensembl = ENSMUSG00000018363
    | Mm_RefseqmRNA = XM_001001801
    | Mm_RefseqProtein = XP_001001801
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 106638115
    | Mm_GenLoc_end = 106736560
    | Mm_Uniprot = 
  }}
}}
'''SMAD specific E3 ubiquitin protein ligase 2''', also known as '''SMURF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64750| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
SMURF2 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[Mothers against decapentaplegic homolog 1]],<ref name = pmid11016919/>
| summary_text =  
* [[Mothers against decapentaplegic homolog 2]],<ref name = pmid11016919/><ref name = pmid11389444/><ref name = pmid19122240/>
}}
* [[Mothers against decapentaplegic homolog 3]],<ref name = pmid11016919 /><ref name = pmid11389444>{{cite journal | vauthors = Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL | title = TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation | journal = Nature Cell Biology | volume = 3 | issue = 6 | pages = 587-95 | date = Jun 2001 | pmid = 11389444 | doi = 10.1038/35078562 }}</ref><ref name = pmid19122240>{{cite journal | vauthors = Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T | title = Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins | journal = The Journal of Biological Chemistry | volume = 284 | issue = 10 | pages = 6109-15 | date = Mar 2009 | pmid = 19122240 | doi = 10.1074/jbc.M804659200 }}</ref>
* [[Mothers against decapentaplegic homolog 7]],<ref name = pmid14722617>{{cite journal | vauthors = Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K | title = Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts | journal = The Journal of Clinical Investigation | volume = 113 | issue = 2 | pages = 253-64 | date = Jan 2004 | pmid = 14722617 | pmc = 310747 | doi = 10.1172/JCI16269 }}</ref><ref name = pmid11163210>{{cite journal | vauthors = Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL | title = Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation | journal = Molecular Cell | volume = 6 | issue = 6 | pages = 1365–75 | date = Dec 2000 | pmid = 11163210 | doi = 10.1016/s1097-2765(00)00134-9}}</ref><ref name = pmid18448069>{{cite journal | vauthors = Lee YS, Han JM, Son SH, Choi JW, Jeon EJ, Bae SC, Park YI, Kim S | title = AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2 | journal = Biochemical and Biophysical Research Communications | volume = 371 | issue = 3 | pages = 395-400 | date = Jul 2008 | pmid = 18448069 | doi = 10.1016/j.bbrc.2008.04.099 }}</ref>
* [[SCYE1]],<ref name = pmid18448069/>  
* [[SMURF1]],<ref name = pmid18927080>{{cite journal | vauthors = Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T | title = Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells | journal = The Journal of Biological Chemistry | volume = 283 | issue = 51 | pages = 35660-7 | date = Dec 2008 | pmid = 18927080 | doi = 10.1074/jbc.M710496200 }}</ref>  and
* [[Ubiquitin C]].<ref name = pmid18448069/><ref name = pmid18671942>{{cite journal | vauthors = Carpentier I, Coornaert B, Beyaert R | title = Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation | journal = Biochemical and Biophysical Research Communications | volume = 374 | issue = 4 | pages = 752-7 | date = Oct 2008 | pmid = 18671942 | doi = 10.1016/j.bbrc.2008.07.103 }}</ref>
{{Div col end}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Lin X, Liang M, Feng XH |title=Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. |journal=J. Biol. Chem. |volume=275 |issue= 47 |pages= 36818-22 |year= 2001 |pmid= 11016919 |doi= 10.1074/jbc.C000580200 }}
*{{cite journal  | author=Zhang Y, Chang C, Gehling DJ, ''et al.'' |title=Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 3 |pages= 974-9 |year= 2001 |pmid= 11158580 |doi= 10.1073/pnas.98.3.974 }}
*{{cite journal  | author=Kavsak P, Rasmussen RK, Causing CG, ''et al.'' |title=Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. |journal=Mol. Cell |volume=6 |issue= 6 |pages= 1365-75 |year= 2001 |pmid= 11163210 |doi=  }}
*{{cite journal  | author=Bonni S, Wang HR, Causing CG, ''et al.'' |title=TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. |journal=Nat. Cell Biol. |volume=3 |issue= 6 |pages= 587-95 |year= 2001 |pmid= 11389444 |doi= 10.1038/35078562 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Subramaniam V, Li H, Wong M, ''et al.'' |title=The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. |journal=Br. J. Cancer |volume=89 |issue= 8 |pages= 1538-44 |year= 2003 |pmid= 14562029 |doi= 10.1038/sj.bjc.6601301 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Asano Y, Ihn H, Yamane K, ''et al.'' |title=Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. |journal=J. Clin. Invest. |volume=113 |issue= 2 |pages= 253-64 |year= 2004 |pmid= 14722617 |doi= 10.1172/JCI200416269 }}
*{{cite journal  | author=Li H, Seth A |title=An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. |journal=Oncogene |volume=23 |issue= 10 |pages= 1801-8 |year= 2004 |pmid= 14755250 |doi= 10.1038/sj.onc.1207319 }}
*{{cite journal  | author=Jin YH, Jeon EJ, Li QL, ''et al.'' |title=Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29409-17 |year= 2004 |pmid= 15138260 |doi= 10.1074/jbc.M313120200 }}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Zhang H, Cohen SN |title=Smurf2 up-regulation activates telomere-dependent senescence. |journal=Genes Dev. |volume=18 |issue= 24 |pages= 3028-40 |year= 2005 |pmid= 15574587 |doi= 10.1101/gad.1253004 }}
*{{cite journal  | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal  | author=Ohashi N, Yamamoto T, Uchida C, ''et al.'' |title=Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta. |journal=FEBS Lett. |volume=579 |issue= 12 |pages= 2557-63 |year= 2005 |pmid= 15862290 |doi= 10.1016/j.febslet.2005.03.069 }}
*{{cite journal  | author=Ogunjimi AA, Briant DJ, Pece-Barbara N, ''et al.'' |title=Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. |journal=Mol. Cell |volume=19 |issue= 3 |pages= 297-308 |year= 2005 |pmid= 16061177 |doi= 10.1016/j.molcel.2005.06.028 }}
*{{cite journal  | author=Chong PA, Lin H, Wrana JL, Forman-Kay JD |title=An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2. |journal=J. Biol. Chem. |volume=281 |issue= 25 |pages= 17069-75 |year= 2006 |pmid= 16641086 |doi= 10.1074/jbc.M601493200 }}
*{{cite journal  | author=Wiesner S, Ogunjimi AA, Wang HR, ''et al.'' |title=Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. |journal=Cell |volume=130 |issue= 4 |pages= 651-62 |year= 2007 |pmid= 17719543 |doi= 10.1016/j.cell.2007.06.050 }}
}}
{{refend}}


{{protein-stub}}
== Further reading ==
{{WikiDoc Sources}}
{{Refbegin | 2}}
* {{cite journal | vauthors = Zhang Y, Chang C, Gehling DJ, Hemmati-Brivanlou A, Derynck R | title = Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 3 | pages = 974-9 | date = Jan 2001 | pmid = 11158580 | pmc = 14694 | doi = 10.1073/pnas.98.3.974 }}
* {{cite journal | vauthors = Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL | title = Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation | journal = Molecular Cell | volume = 6 | issue = 6 | pages = 1365-75 | date = Dec 2000 | pmid = 11163210 | doi = 10.1016/S1097-2765(00)00134-9 }}
* {{cite journal | vauthors = Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL | title = TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation | journal = Nature Cell Biology | volume = 3 | issue = 6 | pages = 587-95 | date = Jun 2001 | pmid = 11389444 | doi = 10.1038/35078562 }}
* {{cite journal | vauthors = Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A | title = The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase | journal = British Journal of Cancer | volume = 89 | issue = 8 | pages = 1538-44 | date = Oct 2003 | pmid = 14562029 | pmc = 2394340 | doi = 10.1038/sj.bjc.6601301 }}
* {{cite journal | vauthors = Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K | title = Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts | journal = The Journal of Clinical Investigation | volume = 113 | issue = 2 | pages = 253-64 | date = Jan 2004 | pmid = 14722617 | pmc = 310747 | doi = 10.1172/JCI16269 }}
* {{cite journal | vauthors = Li H, Seth A | title = An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein | journal = Oncogene | volume = 23 | issue = 10 | pages = 1801-8 | date = Mar 2004 | pmid = 14755250 | doi = 10.1038/sj.onc.1207319 }}
* {{cite journal | vauthors = Jin YH, Jeon EJ, Li QL, Lee YH, Choi JK, Kim WJ, Lee KY, Bae SC | title = Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 28 | pages = 29409-17 | date = Jul 2004 | pmid = 15138260 | doi = 10.1074/jbc.M313120200 }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707-16 | date = Jun 2004 | pmid = 15146197 | doi = 10.1038/nbt971 }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324-32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711-8 | date = Sep 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
* {{cite journal | vauthors = Zhang H, Cohen SN | title = Smurf2 up-regulation activates telomere-dependent senescence | journal = Genes & Development | volume = 18 | issue = 24 | pages = 3028-40 | date = Dec 2004 | pmid = 15574587 | pmc = 535914 | doi = 10.1101/gad.1253004 }}
* {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621-5 | date = Mar 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 }}
* {{cite journal | vauthors = Ohashi N, Yamamoto T, Uchida C, Togawa A, Fukasawa H, Fujigaki Y, Suzuki S, Kitagawa K, Hattori T, Oda T, Hayashi H, Hishida A, Kitagawa M | title = Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta | journal = FEBS Letters | volume = 579 | issue = 12 | pages = 2557-63 | date = May 2005 | pmid = 15862290 | doi = 10.1016/j.febslet.2005.03.069 }}
* {{cite journal | vauthors = Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F, Wrana JL | title = Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain | journal = Molecular Cell | volume = 19 | issue = 3 | pages = 297-308 | date = Aug 2005 | pmid = 16061177 | doi = 10.1016/j.molcel.2005.06.028 }}
* {{cite journal | vauthors = Chong PA, Lin H, Wrana JL, Forman-Kay JD | title = An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 25 | pages = 17069-75 | date = Jun 2006 | pmid = 16641086 | doi = 10.1074/jbc.M601493200 }}
* {{cite journal | vauthors = Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD | title = Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain | journal = Cell | volume = 130 | issue = 4 | pages = 651-62 | date = Aug 2007 | pmid = 17719543 | doi = 10.1016/j.cell.2007.06.050 }}
{{Refend}}
 
{{PDB Gallery|geneid=64750}}
 
{{Gene-17-stub}}

Latest revision as of 02:10, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene.[1][2]

Interactions

SMURF2 has been shown to interact with:

References

  1. ↑ 1.0 1.1 1.2 1.3 Lin X, Liang M, Feng XH (Nov 2000). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling". The Journal of Biological Chemistry. 275 (47): 36818–22. doi:10.1074/jbc.C000580200. PMID 11016919.
  2. ↑ "Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2".
  3. ↑ 3.0 3.1 Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL (Jun 2001). "TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation". Nature Cell Biology. 3 (6): 587–95. doi:10.1038/35078562. PMID 11389444.
  4. ↑ 4.0 4.1 Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T (Mar 2009). "Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins". The Journal of Biological Chemistry. 284 (10): 6109–15. doi:10.1074/jbc.M804659200. PMID 19122240.
  5. ↑ Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K (Jan 2004). "Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts". The Journal of Clinical Investigation. 113 (2): 253–64. doi:10.1172/JCI16269. PMC 310747. PMID 14722617.
  6. ↑ Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL (Dec 2000). "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation". Molecular Cell. 6 (6): 1365–75. doi:10.1016/s1097-2765(00)00134-9. PMID 11163210.
  7. ↑ 7.0 7.1 7.2 Lee YS, Han JM, Son SH, Choi JW, Jeon EJ, Bae SC, Park YI, Kim S (Jul 2008). "AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2". Biochemical and Biophysical Research Communications. 371 (3): 395–400. doi:10.1016/j.bbrc.2008.04.099. PMID 18448069.
  8. ↑ Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T (Dec 2008). "Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells". The Journal of Biological Chemistry. 283 (51): 35660–7. doi:10.1074/jbc.M710496200. PMID 18927080.
  9. ↑ Carpentier I, Coornaert B, Beyaert R (Oct 2008). "Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation". Biochemical and Biophysical Research Communications. 374 (4): 752–7. doi:10.1016/j.bbrc.2008.07.103. PMID 18671942.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=SMURF2&oldid=1417964"