SMTN

Smoothelin
File:PBB Protein SMTN image.jpg PDB rendering based on 2d87.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2d87​
Identifiers
Symbols	SMTN ; FLJ35365; FLJ38597
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8482
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SMTN 207390 s at tn.png
File:PBB GE SMTN 209427 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Smoothelin, also known as SMTN, is a human gene.

This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.

Further reading

• Luft FC (1999). "Differentiating one smooth operator from another". J. Mol. Med. 77 (2): 255–7. PMID 10023778.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• van der Loop FT, Schaart G, Timmer ED; et al. (1996). "Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells". J. Cell Biol. 134 (2): 401–11. PMID 8707825.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Eys GJ, Völler MC, Timmer ED; et al. (1997). "Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant". Cell Struct. Funct. 22 (1): 65–72. PMID 9113392.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Engelen JJ, Esterling LE, Albrechts JC; et al. (1997). "Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 43 (2): 245–7. doi:10.1006/geno.1997.9999. PMID 9244445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
• Krämer J, Aguirre-Arteta AM, Thiel C; et al. (1999). "A novel isoform of the smooth muscle cell differentiation marker smoothelin". J. Mol. Med. 77 (2): 294–8. PMID 10023782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Johansson B, Eriksson A, Ramaekers F, Thornell L (2000). "Smoothelin in adult and developing human arteries and myocardium". Histochem. Cell Biol. 112 (4): 291–9. PMID 10550614.CS1 maint: Multiple names: authors list (link)
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gsell S, Eschenhagen T, Kaspareit G; et al. (2000). "Apparent up-regulation of stimulatory G-protein alpha subunits in the pregnant human myometrium is mimicked by elevated smoothelin expression". FASEB J. 14 (1): 17–26. PMID 10627276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krämer J, Quensel C, Meding J; et al. (2001). "Identification and characterization of novel smoothelin isoforms in vascular smooth muscle". J. Vasc. Res. 38 (2): 120–32. PMID 11316948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rensen SS, Thijssen VL, De Vries CJ; et al. (2002). "Expression of the smoothelin gene is mediated by alternative promoters". Cardiovasc. Res. 55 (4): 850–63. PMID 12176134.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)