SMC1A

Structural maintenance of chromosomes 1A
Identifiers
Symbols	SMC1A ; DKFZp686L19178; DXS423E; KIAA0178; MGC138332; SB1.8; SMC1; SMC1L1; SMC1alpha; SMCB
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4597
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SMC1A 201589 at tn.png
File:PBB GE SMC1A 217555 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Structural maintenance of chromosomes 1A, also known as SMC1A, is a human gene.

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.

See also

• SMC protein

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rocques PJ, Clark J, Ball S; et al. (1995). "The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes". Hum. Mol. Genet. 4 (2): 243–9. PMID 7757074.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brown CJ, Miller AP, Carrel L; et al. (1995). "The DXS423E gene in Xp11.21 escapes X chromosome inactivation". Hum. Mol. Genet. 4 (2): 251–5. PMID 7757075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matoba R, Okubo K, Hori N; et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. PMID 8076819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Seki N, Ishikawa K; et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. PMID 8724849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen Y, Sharp ZD, Lee WH (1997). "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins". J. Biol. Chem. 272 (38): 24081–7. PMID 9295362.CS1 maint: Multiple names: authors list (link)
• Schmiesing JA, Ball AR, Gregson HC; et al. (1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 12906–11. PMID 9789013.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zheng L, Chen Y, Lee WH (1999). "Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins". Mol. Cell. Biol. 19 (8): 5417–28. PMID 10409732.CS1 maint: Multiple names: authors list (link)
• Losada A, Yokochi T, Kobayashi R, Hirano T (2000). "Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes". J. Cell Biol. 150 (3): 405–16. PMID 10931856.CS1 maint: Multiple names: authors list (link)
• Sumara I, Vorlaufer E, Gieffers C; et al. (2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. PMID 11076961.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Revenkova E, Eijpe M, Heyting C; et al. (2001). "Novel meiosis-specific isoform of mammalian SMC1". Mol. Cell. Biol. 21 (20): 6984–98. doi:10.1128/MCB.21.20.6984-6998.2001. PMID 11564881.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregson HC, Schmiesing JA, Kim JS; et al. (2002). "A potential role for human cohesin in mitotic spindle aster assembly". J. Biol. Chem. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID 11590136.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim ST, Xu B, Kastan MB (2002). "Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage". Genes Dev. 16 (5): 560–70. doi:10.1101/gad.970602. PMID 11877376.CS1 maint: Multiple names: authors list (link)
• Yazdi PT, Wang Y, Zhao S; et al. (2002). "SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint". Genes Dev. 16 (5): 571–82. doi:10.1101/gad.970702. PMID 11877377.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregson HC, Van Hooser AA, Ball AR; et al. (2003). "Localization of human SMC1 protein at kinetochores". Chromosome Res. 10 (4): 267–77. PMID 12199140.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stewart GS, Wang B, Bignell CR; et al. (2003). "MDC1 is a mediator of the mammalian DNA damage checkpoint". Nature. 421 (6926): 961–6. doi:10.1038/nature01446. PMID 12607005.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Y, Qin J (2004). "MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15387–92. doi:10.1073/pnas.2536810100. PMID 14657349.