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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Probable global transcription activator SNF2L2''' is a [[protein]] that in humans is encoded by the ''SMARCA2'' [[gene]].<ref name="pmid8012116">{{cite journal | vauthors = Muchardt C, Yaniv M, Mattei MG | title = Assignment of HBRM, the human homolog of S. cerevisiae SNF2/SWI2 and Drosophila brm genes, to chromosome region 9p23-p24, by in situ hybridization | journal = Mammalian Genome | volume = 5 | issue = 4 | pages = 241–3 | date = Apr 1994 | pmid = 8012116 | pmc =  | doi = 10.1007/BF00360554 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6595| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SMARCA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dat.
| PDB = {{PDB2|2dat}}
| Name = SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
| HGNCid = 11098
| Symbol = SMARCA2
| AltSymbols =; SWI2; BAF190; BRM; FLJ36757; MGC74511; SNF2; SNF2L2; SNF2LA; Sth1p; hBRM; hSNF2a
| OMIM = 600014
| ECnumber = 
| Homologene = 2308
| MGIid = 99603
| GeneAtlas_image1 = PBB_GE_SMARCA2_206542_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMARCA2_206544_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_SMARCA2_217707_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6595
    | Hs_Ensembl = ENSG00000080503
    | Hs_RefseqProtein = NP_003061
    | Hs_RefseqmRNA = NM_003070
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 2005342
    | Hs_GenLoc_end = 2183624
    | Hs_Uniprot = P51531
    | Mm_EntrezGene = 67155
    | Mm_Ensembl = ENSMUSG00000024921
    | Mm_RefseqmRNA = NM_011416
    | Mm_RefseqProtein = NP_035546
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 26672257
    | Mm_GenLoc_end = 26845418
    | Mm_Uniprot = 
  }}
}}
'''SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2''', also known as '''SMARCA2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6595| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the [[SWI/SNF]] family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.<ref name="entrez">{{cite web | title = Entrez Gene: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6595| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Aves SJ, Hindley J, Phear GA, Tongue N |title=A fission yeast gene mapping close to suc1 encodes a protein containing two bromodomains. |journal=Mol. Gen. Genet. |volume=248 |issue= 4 |pages= 491-8 |year= 1995 |pmid= 7565614 |doi=  }}
*{{cite journal  | author=Muchardt C, Yaniv M, Mattei MG |title=Assignment of HBRM, the human homolog of S. cerevisiae SNF2/SWI2 and Drosophila brm genes, to chromosome region 9p23-p24, by in situ hybridization. |journal=Mamm. Genome |volume=5 |issue= 4 |pages= 241-3 |year= 1994 |pmid= 8012116 |doi=  }}
*{{cite journal  | author=Chiba H, Muramatsu M, Nomoto A, Kato H |title=Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor. |journal=Nucleic Acids Res. |volume=22 |issue= 10 |pages= 1815-20 |year= 1994 |pmid= 8208605 |doi=  }}
*{{cite journal  | author=Muchardt C, Yaniv M |title=A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. |journal=EMBO J. |volume=12 |issue= 11 |pages= 4279-90 |year= 1993 |pmid= 8223438 |doi=  }}
*{{cite journal  | author=Muchardt C, Reyes JC, Bourachot B, ''et al.'' |title=The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis. |journal=EMBO J. |volume=15 |issue= 13 |pages= 3394-402 |year= 1996 |pmid= 8670841 |doi=  }}
*{{cite journal  | author=Wang W, Xue Y, Zhou S, ''et al.'' |title=Diversity and specialization of mammalian SWI/SNF complexes. |journal=Genes Dev. |volume=10 |issue= 17 |pages= 2117-30 |year= 1996 |pmid= 8804307 |doi=  }}
*{{cite journal  | author=Wang W, Côté J, Xue Y, ''et al.'' |title=Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. |journal=EMBO J. |volume=15 |issue= 19 |pages= 5370-82 |year= 1996 |pmid= 8895581 |doi=  }}
*{{cite journal  | author=Ichinose H, Garnier JM, Chambon P, Losson R |title=Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2. |journal=Gene |volume=188 |issue= 1 |pages= 95-100 |year= 1997 |pmid= 9099865 |doi=  }}
*{{cite journal  | author=Cho H, Orphanides G, Sun X, ''et al.'' |title=A human RNA polymerase II complex containing factors that modify chromatin structure. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5355-63 |year= 1998 |pmid= 9710619 |doi=  }}
*{{cite journal  | author=Thaete C, Brett D, Monaghan P, ''et al.'' |title=Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 585-91 |year= 1999 |pmid= 10072425 |doi=  }}
*{{cite journal  | author=Phelan ML, Sif S, Narlikar GJ, Kingston RE |title=Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. |journal=Mol. Cell |volume=3 |issue= 2 |pages= 247-53 |year= 1999 |pmid= 10078207 |doi=  }}
*{{cite journal  | author=Lee DW, Zhang K, Ning ZQ, ''et al.'' |title=Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia. |journal=Cancer Res. |volume=60 |issue= 13 |pages= 3612-22 |year= 2000 |pmid= 10910076 |doi=  }}
*{{cite journal  | author=Phelan ML, Schnitzler GR, Kingston RE |title=Octamer transfer and creation of stably remodeled nucleosomes by human SWI-SNF and its isolated ATPases. |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6380-9 |year= 2000 |pmid= 10938115 |doi=  }}
*{{cite journal  | author=Xue Y, Canman JC, Lee CS, ''et al.'' |title=The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 24 |pages= 13015-20 |year= 2001 |pmid= 11078522 |doi= 10.1073/pnas.240208597 }}
*{{cite journal  | author=Machida Y, Murai K, Miyake K, Iijima S |title=Expression of chromatin remodeling factors during neural differentiation. |journal=J. Biochem. |volume=129 |issue= 1 |pages= 43-9 |year= 2001 |pmid= 11134956 |doi=  }}
*{{cite journal  | author=de la Serna IL, Carlson KA, Imbalzano AN |title=Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation. |journal=Nat. Genet. |volume=27 |issue= 2 |pages= 187-90 |year= 2001 |pmid= 11175787 |doi= 10.1038/84826 }}
*{{cite journal  | author=Ruhf ML, Braun A, Papoulas O, ''et al.'' |title=The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes. |journal=Development |volume=128 |issue= 8 |pages= 1429-41 |year= 2001 |pmid= 11262242 |doi=  }}
*{{cite journal  | author=Strobeck MW, Reisman DN, Gunawardena RW, ''et al.'' |title=Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4782-9 |year= 2002 |pmid= 11719516 |doi= 10.1074/jbc.M109532200 }}
*{{cite journal  | author=Kato H, Tjernberg A, Zhang W, ''et al.'' |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498-505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200 }}
*{{cite journal  | author=Mizutani T, Ito T, Nishina M, ''et al.'' |title=Maintenance of integrated proviral gene expression requires Brm, a catalytic subunit of SWI/SNF complex. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15859-64 |year= 2002 |pmid= 11850427 |doi= 10.1074/jbc.M112421200 }}
}}
{{refend}}


{{protein-stub}}
SMARCA2 has been shown to [[Protein-protein interaction|interact]] with:
{{WikiDoc Sources}}
{{div col|colwidth=20em}}
* [[ACTL6A]],<ref name = pmid8895581>{{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | journal = The EMBO Journal | volume = 15 | issue = 19 | pages = 5370–82 | date = Oct 1996 | pmid = 8895581 | pmc = 452280 | doi =  }}</ref><ref name = pmid11839798>{{cite journal | vauthors = Park J, Wood MA, Cole MD | title = BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation | journal = Molecular and Cellular Biology | volume = 22 | issue = 5 | pages = 1307–16 | date = Mar 2002 | pmid = 11839798 | pmc = 134713 | doi =  10.1128/mcb.22.5.1307-1316.2002}}</ref><ref name = pmid12437990>{{cite journal | vauthors = Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M | title = Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex | journal = Biochemical and Biophysical Research Communications | volume = 299 | issue = 2 | pages = 328–34 | date = Nov 2002 | pmid = 12437990 | doi =  10.1016/s0006-291x(02)02637-2}}</ref>
* [[ARID1B]],<ref name = pmid12200431>{{cite journal | vauthors = Inoue H, Furukawa T, Giannakopoulos S, Zhou S, King DS, Tanese N | title = Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors | journal = The Journal of Biological Chemistry | volume = 277 | issue = 44 | pages = 41674–85 | date = Nov 2002 | pmid = 12200431 | doi = 10.1074/jbc.M205961200 }}</ref>
* [[CEBPB]],<ref name = pmid10619021>{{cite journal | vauthors = Kowenz-Leutz E, Leutz A | title = A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes | journal = Molecular Cell | volume = 4 | issue = 5 | pages = 735–43 | date = Nov 1999 | pmid = 10619021 | doi =  10.1016/s1097-2765(00)80384-6}}</ref>
* [[POLR2A]],<ref name = pmid8895581/><ref name = pmid11238380/><ref name = pmid9710619>{{cite journal | vauthors = Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D | title = A human RNA polymerase II complex containing factors that modify chromatin structure | journal = Molecular and Cellular Biology | volume = 18 | issue = 9 | pages = 5355–63 | date = Sep 1998 | pmid = 9710619 | pmc = 109120 | doi =  }}</ref>
* [[Prohibitin]],<ref name = pmid12065415>{{cite journal | vauthors = Wang S, Zhang B, Faller DV | title = Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth | journal = The EMBO Journal | volume = 21 | issue = 12 | pages = 3019–28 | date = Jun 2002 | pmid = 12065415 | pmc = 126057 | doi = 10.1093/emboj/cdf302 }}</ref>
* [[SIN3A]],<ref name = pmid11238380>{{cite journal | vauthors = Sif S, Saurin AJ, Imbalzano AN, Kingston RE | title = Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes | journal = Genes & Development | volume = 15 | issue = 5 | pages = 603–18 | date = Mar 2001 | pmid = 11238380 | pmc = 312641 | doi = 10.1101/gad.872801 }}</ref>
* [[SMARCB1]],<ref name = pmid8895581/><ref name = pmid11238380/>
* [[SMARCC1]],<ref name = pmid8895581/><ref name = pmid11238380/>  and
* [[SS18]].<ref name = pmid14603256>{{cite journal | vauthors = Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH | title = Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers | journal = Oncogene | volume = 22 | issue = 50 | pages = 8156–67 | date = Nov 2003 | pmid = 14603256 | doi = 10.1038/sj.onc.1207031 }}</ref>
{{Div col end}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Aves SJ, Hindley J, Phear GA, Tongue N | title = A fission yeast gene mapping close to suc1 encodes a protein containing two bromodomains | journal = Molecular & General Genetics | volume = 248 | issue = 4 | pages = 491–8 | date = Aug 1995 | pmid = 7565614 | doi = 10.1007/BF02191650 }}
* {{cite journal | vauthors = Chiba H, Muramatsu M, Nomoto A, Kato H | title = Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor | journal = Nucleic Acids Research | volume = 22 | issue = 10 | pages = 1815–20 | date = May 1994 | pmid = 8208605 | pmc = 308079 | doi = 10.1093/nar/22.10.1815 }}
* {{cite journal | vauthors = Muchardt C, Yaniv M | title = A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor | journal = The EMBO Journal | volume = 12 | issue = 11 | pages = 4279–90 | date = Nov 1993 | pmid = 8223438 | pmc = 413724 | doi =  }}
* {{cite journal | vauthors = Muchardt C, Reyes JC, Bourachot B, Leguoy E, Yaniv M | title = The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis | journal = The EMBO Journal | volume = 15 | issue = 13 | pages = 3394–402 | date = Jul 1996 | pmid = 8670841 | pmc = 451903 | doi =  }}
* {{cite journal | vauthors = Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR | title = Diversity and specialization of mammalian SWI/SNF complexes | journal = Genes & Development | volume = 10 | issue = 17 | pages = 2117–30 | date = Sep 1996 | pmid = 8804307 | doi = 10.1101/gad.10.17.2117 }}
* {{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | journal = The EMBO Journal | volume = 15 | issue = 19 | pages = 5370–82 | date = Oct 1996 | pmid = 8895581 | pmc = 452280 | doi =  }}
* {{cite journal | vauthors = Ichinose H, Garnier JM, Chambon P, Losson R | title = Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2 | journal = Gene | volume = 188 | issue = 1 | pages = 95–100 | date = Mar 1997 | pmid = 9099865 | doi = 10.1016/S0378-1119(96)00785-8 }}
* {{cite journal | vauthors = Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D | title = A human RNA polymerase II complex containing factors that modify chromatin structure | journal = Molecular and Cellular Biology | volume = 18 | issue = 9 | pages = 5355–63 | date = Sep 1998 | pmid = 9710619 | pmc = 109120 | doi =  }}
* {{cite journal | vauthors = Thaete C, Brett D, Monaghan P, Whitehouse S, Rennie G, Rayner E, Cooper CS, Goodwin G | title = Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus | journal = Human Molecular Genetics | volume = 8 | issue = 4 | pages = 585–91 | date = Apr 1999 | pmid = 10072425 | doi = 10.1093/hmg/8.4.585 }}
* {{cite journal | vauthors = Phelan ML, Sif S, Narlikar GJ, Kingston RE | title = Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits | journal = Molecular Cell | volume = 3 | issue = 2 | pages = 247–53 | date = Feb 1999 | pmid = 10078207 | doi = 10.1016/S1097-2765(00)80315-9 }}
* {{cite journal | vauthors = Lee DW, Zhang K, Ning ZQ, Raabe EH, Tintner S, Wieland R, Wilkins BJ, Kim JM, Blough RI, Arceci RJ | title = Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia | journal = Cancer Research | volume = 60 | issue = 13 | pages = 3612–22 | date = Jul 2000 | pmid = 10910076 | doi =  }}
* {{cite journal | vauthors = Phelan ML, Schnitzler GR, Kingston RE | title = Octamer transfer and creation of stably remodeled nucleosomes by human SWI-SNF and its isolated ATPases | journal = Molecular and Cellular Biology | volume = 20 | issue = 17 | pages = 6380–9 | date = Sep 2000 | pmid = 10938115 | pmc = 86113 | doi = 10.1128/MCB.20.17.6380-6389.2000 }}
* {{cite journal | vauthors = Xue Y, Canman JC, Lee CS, Nie Z, Yang D, Moreno GT, Young MK, Salmon ED, Wang W | title = The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 24 | pages = 13015–20 | date = Nov 2000 | pmid = 11078522 | pmc = 27170 | doi = 10.1073/pnas.240208597 }}
* {{cite journal | vauthors = Machida Y, Murai K, Miyake K, Iijima S | title = Expression of chromatin remodeling factors during neural differentiation | journal = Journal of Biochemistry | volume = 129 | issue = 1 | pages = 43–9 | date = Jan 2001 | pmid = 11134956 | doi = 10.1093/oxfordjournals.jbchem.a002834 }}
* {{cite journal | vauthors = de la Serna IL, Carlson KA, Imbalzano AN | title = Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation | journal = Nature Genetics | volume = 27 | issue = 2 | pages = 187–90 | date = Feb 2001 | pmid = 11175787 | doi = 10.1038/84826 }}
* {{cite journal | vauthors = Ruhf ML, Braun A, Papoulas O, Tamkun JW, Randsholt N, Meister M | title = The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes | journal = Development | volume = 128 | issue = 8 | pages = 1429–41 | date = Apr 2001 | pmid = 11262242 | doi =  }}
* {{cite journal | vauthors = Strobeck MW, Reisman DN, Gunawardena RW, Betz BL, Angus SP, Knudsen KE, Kowalik TF, Weissman BE, Knudsen ES | title = Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling | journal = The Journal of Biological Chemistry | volume = 277 | issue = 7 | pages = 4782–9 | date = Feb 2002 | pmid = 11719516 | doi = 10.1074/jbc.M109532200 }}
* {{cite journal | vauthors = Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG | title = SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones | journal = The Journal of Biological Chemistry | volume = 277 | issue = 7 | pages = 5498–505 | date = Feb 2002 | pmid = 11734557 | doi = 10.1074/jbc.M108702200 }}
* {{cite journal | vauthors = Mizutani T, Ito T, Nishina M, Yamamichi N, Watanabe A, Iba H | title = Maintenance of integrated proviral gene expression requires Brm, a catalytic subunit of SWI/SNF complex | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 15859–64 | date = May 2002 | pmid = 11850427 | doi = 10.1074/jbc.M112421200 }}
{{Refend}}
 
{{PDB Gallery|geneid=6595}}

Latest revision as of 07:35, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene.[1][2]

Function

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.[2]

Interactions

SMARCA2 has been shown to interact with:

References

  1. ↑ Muchardt C, Yaniv M, Mattei MG (Apr 1994). "Assignment of HBRM, the human homolog of S. cerevisiae SNF2/SWI2 and Drosophila brm genes, to chromosome region 9p23-p24, by in situ hybridization". Mammalian Genome. 5 (4): 241–3. doi:10.1007/BF00360554. PMID 8012116.
  2. ↑ 2.0 2.1 "Entrez Gene: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2".
  3. ↑ 3.0 3.1 3.2 3.3 Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR (Oct 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". The EMBO Journal. 15 (19): 5370–82. PMC 452280. PMID 8895581.
  4. ↑ Park J, Wood MA, Cole MD (Mar 2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Molecular and Cellular Biology. 22 (5): 1307–16. doi:10.1128/mcb.22.5.1307-1316.2002. PMC 134713. PMID 11839798.
  5. ↑ Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M (Nov 2002). "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex". Biochemical and Biophysical Research Communications. 299 (2): 328–34. doi:10.1016/s0006-291x(02)02637-2. PMID 12437990.
  6. ↑ Inoue H, Furukawa T, Giannakopoulos S, Zhou S, King DS, Tanese N (Nov 2002). "Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors". The Journal of Biological Chemistry. 277 (44): 41674–85. doi:10.1074/jbc.M205961200. PMID 12200431.
  7. ↑ Kowenz-Leutz E, Leutz A (Nov 1999). "A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes". Molecular Cell. 4 (5): 735–43. doi:10.1016/s1097-2765(00)80384-6. PMID 10619021.
  8. ↑ 8.0 8.1 8.2 8.3 Sif S, Saurin AJ, Imbalzano AN, Kingston RE (Mar 2001). "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes". Genes & Development. 15 (5): 603–18. doi:10.1101/gad.872801. PMC 312641. PMID 11238380.
  9. ↑ Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (Sep 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Molecular and Cellular Biology. 18 (9): 5355–63. PMC 109120. PMID 9710619.
  10. ↑ Wang S, Zhang B, Faller DV (Jun 2002). "Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth". The EMBO Journal. 21 (12): 3019–28. doi:10.1093/emboj/cdf302. PMC 126057. PMID 12065415.
  11. ↑ Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene. 22 (50): 8156–67. doi:10.1038/sj.onc.1207031. PMID 14603256.

Further reading

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