SLC26A8: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Testis anion transporter 1''' is a [[protein]] that in humans is encoded by the ''SLC26A8'' [[gene]].<ref name="pmid11834742">{{cite journal | vauthors = Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J | title = Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9 | journal = J. Biol. Chem. | volume = 277 | issue = 16 | pages = 14246–54  | date = Apr 2002 | pmid = 11834742 | pmc =  | doi = 10.1074/jbc.M111802200 }}</ref><ref name="pmid11829495">{{cite journal | vauthors = Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP | title = Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney | journal = Genomics | volume = 79 | issue = 2 | pages = 249–56  | date = Feb 2002 | pmid = 11829495 | pmc = | doi = 10.1006/geno.2002.6689 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC26A8 solute carrier family 26, member 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116369| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 26, member 8
| HGNCid = 14468
| Symbol = SLC26A8
| AltSymbols =; FLJ32714; TAT1
| OMIM = 608480
| ECnumber = 
| Homologene = 27095
| MGIid = 2385046
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}}
| Component = {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 116369
    | Hs_Ensembl = ENSG00000112053
    | Hs_RefseqProtein = NP_443193
    | Hs_RefseqmRNA = NM_052961
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 36019273
    | Hs_GenLoc_end = 36100355
    | Hs_Uniprot = 
    | Mm_EntrezGene = 224661
    | Mm_Ensembl = ENSMUSG00000036196
    | Mm_RefseqmRNA = NM_146076
    | Mm_RefseqProtein = NP_666188
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 28365916
    | Mm_GenLoc_end = 28417576
    | Mm_Uniprot = 
  }}
}}
'''Solute carrier family 26, member 8''', also known as '''SLC26A8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC26A8 solute carrier family 26, member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116369| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.<ref name="entrez">{{cite web | title = Entrez Gene: SLC26A8 solute carrier family 26, member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116369| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SLC26A8 has been shown to [[Protein-protein interaction|interact]] with [[RACGAP1]].<ref name=pmid11278976>{{cite journal | vauthors = Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G | title = Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling | journal = J. Biol. Chem. | volume = 276 | issue = 23 | pages = 20309–15  | date = Jun 2001 | pmid = 11278976 | doi = 10.1074/jbc.M011740200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Markovich D | title = Physiological roles and regulation of mammalian sulfate transporters | journal = Physiol. Rev. | volume = 81 | issue = 4 | pages = 1499–533 | year = 2001 | pmid = 11581495 | doi =  }}
| citations =
* {{cite journal | vauthors = Mäkelä S, Eklund R, Lähdetie J, Mikkola M, Hovatta O, Kere J | title = Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure | journal = Mol. Hum. Reprod. | volume = 11 | issue = 2 | pages = 129–32 | year = 2005 | pmid = 15579655 | doi = 10.1093/molehr/gah140 }}
*{{cite journal | author=Markovich D |title=Physiological roles and regulation of mammalian sulfate transporters. |journal=Physiol. Rev. |volume=81 |issue= 4 |pages= 1499-533 |year= 2001 |pmid= 11581495 |doi=  }}
* {{cite journal | vauthors = Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G | title = Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling | journal = J. Biol. Chem. | volume = 276 | issue = 23 | pages = 20309–15 | year = 2001 | pmid = 11278976 | doi = 10.1074/jbc.M011740200 }}
*{{cite journal | author=Mäkelä S, Eklund R, Lähdetie J, ''et al.'' |title=Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure. |journal=Mol. Hum. Reprod. |volume=11 |issue= 2 |pages= 129-32 |year= 2005 |pmid= 15579655 |doi= 10.1093/molehr/gah140 }}
* {{cite journal | vauthors = Mocellin R, Bühlmeyer K | title = Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension | journal = Eur J Cardiol | volume = 3 | issue = 3 | pages = 205–11 | year = 1975 | pmid = 1183472 | doi =  }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Lohi H, Kujala M, Makela S, ''et al.'' |title=Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 14246-54 |year= 2002 |pmid= 11834742 |doi= 10.1074/jbc.M111802200 }}
*{{cite journal  | author=Vincourt JB, Jullien D, Kossida S, ''et al.'' |title=Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney. |journal=Genomics |volume=79 |issue= 2 |pages= 249-56 |year= 2002 |pmid= 11829495 |doi= 10.1006/geno.2002.6689 }}
*{{cite journal  | author=Toure A, Morin L, Pineau C, ''et al.'' |title=Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20309-15 |year= 2001 |pmid= 11278976 |doi= 10.1074/jbc.M011740200 }}
*{{cite journal | author=Mocellin R, Bühlmeyer K |title=Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension. |journal=European journal of cardiology |volume=3 |issue= 3 |pages= 205-11 |year= 1976 |pmid= 1183472 |doi=  }}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:40, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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PubMed searchn/an/a
Wikidata
View/Edit Human

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.[1][2][3]

Function

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.[3]

Interactions

SLC26A8 has been shown to interact with RACGAP1.[4]

References

  1. ↑ Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (Apr 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". J. Biol. Chem. 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742.
  2. ↑ Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (Feb 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics. 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495.
  3. ↑ 3.0 3.1 "Entrez Gene: SLC26A8 solute carrier family 26, member 8".
  4. ↑ Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (Jun 2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.

Further reading

  • Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. PMID 11581495.
  • Mäkelä S, Eklund R, Lähdetie J, Mikkola M, Hovatta O, Kere J (2005). "Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure". Mol. Hum. Reprod. 11 (2): 129–32. doi:10.1093/molehr/gah140. PMID 15579655.
  • Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.
  • Mocellin R, Bühlmeyer K (1975). "Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension". Eur J Cardiol. 3 (3): 205–11. PMID 1183472.


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