SLC22A8

Solute carrier family 22 (organic anion transporter), member 8
Identifiers
Symbols	SLC22A8 ; MGC24086; OAT3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20901
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SLC22A8 221298 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Solute carrier family 22 (organic anion transporter), member 8, also known as SLC22A8, is a human gene.

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney.

Further reading

• Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999). "Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)". Biochem. Biophys. Res. Commun. 255 (2): 508–14. doi:10.1006/bbrc.1998.9978. PMID 10049739.CS1 maint: Multiple names: authors list (link)
• Babu E, Takeda M, Narikawa S; et al. (2002). "Human organic anion transporters mediate the transport of tetracycline". Jpn. J. Pharmacol. 88 (1): 69–76. PMID 11855680.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Motohashi H, Sakurai Y, Saito H; et al. (2002). "Gene expression levels and immunolocalization of organic ion transporters in the human kidney". J. Am. Soc. Nephrol. 13 (4): 866–74. PMID 11912245.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishizato Y, Ieiri I, Suzuki H; et al. (2003). "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics". Clin. Pharmacol. Ther. 73 (6): 554–65. doi:10.1016/S0009-9236(03)00060-2. PMID 12811365.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bakhiya A, Bahn A, Burckhardt G, Wolff N (2004). "Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux". Cell. Physiol. Biochem. 13 (5): 249–56. doi:10.1159/000074539. PMID 14586168.CS1 maint: Multiple names: authors list (link)
• Sakurai Y, Motohashi H, Ueo H; et al. (2004). "Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases". Pharm. Res. 21 (1): 61–7. PMID 14984259.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Srimaroeng C, Chatsudthipong V, Aslamkhan AG, Pritchard JB (2005). "Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)". J. Pharmacol. Exp. Ther. 313 (2): 621–8. doi:10.1124/jpet.104.080366. PMID 15644426.CS1 maint: Multiple names: authors list (link)
• Tahara H, Shono M, Kusuhara H; et al. (2006). "Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney". Pharm. Res. 22 (4): 647–60. doi:10.1007/s11095-005-2503-0. PMID 15846473.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Erdman AR, Mangravite LM, Urban TJ; et al. (2006). "The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics". Am. J. Physiol. Renal Physiol. 290 (4): F905–12. doi:10.1152/ajprenal.00272.2005. PMID 16291576.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tahara H, Kusuhara H, Maeda K; et al. (2006). "Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid". Drug Metab. Dispos. 34 (5): 743–7. doi:10.1124/dmd.105.008375. PMID 16455804.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bhatnagar V, Xu G, Hamilton BA; et al. (2006). "Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3)". J. Hum. Genet. 51 (6): 575–80. doi:10.1007/s10038-006-0398-1. PMID 16648942.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kikuchi R, Kusuhara H, Hattori N; et al. (2006). "Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation". Mol. Pharmacol. 70 (3): 887–96. doi:10.1124/mol.106.025494. PMID 16793932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mizuno N, Takahashi T, Iwase Y; et al. (2007). "Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate". Drug Metab. Dispos. 35 (8): 1429–34. doi:10.1124/dmd.106.013912. PMID 17502342.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsumoto S, Yoshida K, Ishiguro N; et al. (2007). "Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride]". J. Pharmacol. Exp. Ther. 322 (3): 1246–52. doi:10.1124/jpet.107.123323. PMID 17556638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nozaki Y, Kusuhara H, Kondo T; et al. (2007). "Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices". J. Pharmacol. Exp. Ther. 322 (3): 1162–70. doi:10.1124/jpet.107.121491. PMID 17578901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• VanWert AL, Bailey RM, Sweet DH (2007). "Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G.". Am. J. Physiol. Renal Physiol. 293 (4): F1332–41. doi:10.1152/ajprenal.00319.2007. PMID 17686950.CS1 maint: Multiple names: authors list (link)
• VanWert AL, Sweet DH (2007). "Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: A gender specific impact of reduced folates". Pharm. Res. [Epub ahead of print]. doi:10.1007/s11095-007-9407-0. PMID 17660957.
• Windass AS, Lowes S, Wang Y, Brown CD (2007). "The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin". J. Pharmacol. Exp. Ther. 322 (3): 1221–7. doi:10.1124/jpet.107.125831. PMID 17585018.CS1 maint: Multiple names: authors list (link)