SKAP1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
(Reverted edit by QuackityIsHot (talk))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Src kinase-associated phosphoprotein 1''' is an [[Signal transducing adaptor protein|adapter protein]] that in humans is encoded by the ''SKAP1'' [[gene]].<ref name="pmid9195899">{{cite journal | vauthors = Marie-Cardine A, Bruyns E, Eckerskorn C, Kirchgessner H, Meuer SC, Schraven B | title = Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes | journal = The Journal of Biological Chemistry | volume = 272 | issue = 26 | pages = 16077–80 | date = June 1997 | pmid = 9195899 | pmc =  | doi = 10.1074/jbc.272.26.16077 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SKAP1 src kinase associated phosphoprotein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8631| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a [[T cell]] adapter protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a [[PH domain]] and C-terminal [[SH3 domain]]. Along with the adhesion and degranulation-promoting adapter protein, the encoded protein plays a critical role in [[inside-out signaling]] by coupling T-cell antigen receptor stimulation to the activation of [[integrin]]s.<ref name="entrez" />
{{GNF_Protein_box
| image = PBB_Protein_SKAP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1u5d.
| PDB = {{PDB2|1u5d}}
| Name = Src kinase associated phosphoprotein 1
| HGNCid = 15605
| Symbol = SKAP1
| AltSymbols =; SCAP1; SKAP55
| OMIM = 604969
| ECnumber = 
| Homologene = 2764
| MGIid = 1925723
| GeneAtlas_image1 = PBB_GE_SKAP1_205790_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8631
    | Hs_Ensembl = ENSG00000141293
    | Hs_RefseqProtein = NP_001068567
    | Hs_RefseqmRNA = NM_001075099
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 43565804
    | Hs_GenLoc_end = 43862551
    | Hs_Uniprot = Q86WV1
    | Mm_EntrezGene = 78473
    | Mm_Ensembl = ENSMUSG00000057058
    | Mm_RefseqmRNA = NM_001033186
    | Mm_RefseqProtein = NP_001028358
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 96280683
    | Mm_GenLoc_end = 96575712
    | Mm_Uniprot = Q3UUV5
  }}
}}
'''Src kinase associated phosphoprotein 1''', also known as '''SKAP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SKAP1 src kinase associated phosphoprotein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8631| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The demonstration that SKAP1 regulates [[LFA-1]] adhesion was made by retroviral infection <ref>{{cite journal | vauthors = Wang H, Moon EY, Azouz A, Wu X, Smith A, Schneider H, Hogg N, Rudd CE | title = SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates | journal = Nature Immunology | volume = 4 | issue = 4 | pages = 366–74 | date = April 2003 | pmid = 12652296 | doi = 10.1038/ni913 }}</ref> and by the SKAP1 deficient mouse.<ref>Wang H, Liu H, Lu Y, Lovatt M, Wei, B, Rudd CE  Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion, Mol. Cell. Biol. 2007 27, 6863-75.</ref>  Additional work has implicated SKAP1 in binding to the [[Guanine nucleotide exchange factor|exchange factor]] [[RASGRP1|RasGRP1]] and in regulating [[Extracellular signal-regulated kinases|ERK]] activation in T-cells.<ref>* {{cite journal | vauthors = Kosco KA, Cerignoli F, Williams S, Abraham RT, Mustelin T | title = SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1 | journal = Molecular Immunology | volume = 45 | issue = 2 | pages = 510–22 | date = January 2008 | pmid = 17658605 | doi = 10.1016/j.molimm.2007.05.024 }}</ref><ref>Schneider H., Wang H., Raab M., Valk E.,  Smith X. , Lovatt M.,  Wu Z., Strebhardt K, Rudd, CE.  Adaptor SKAP55 binds RasGRP1 and negatively regulates p21ras and the ERK pathway in T-cells. (2008) PLoS ONE. 3, 1718.</ref>
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.<ref name="entrez">{{cite web | title = Entrez Gene: SKAP1 src kinase associated phosphoprotein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8631| accessdate = }}</ref>
}}


The demonstration that SKAP1 regulates LFA-1 adhesion was made by retroviral infection <ref>{{cite journal  | author=Wang H, Moon EY, Azouz A, ''et al.'' |title=SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. |journal=Nat. Immunol. |volume=4 |issue= 4 |pages= 366-74 |year= 2003 |pmid= 12652296 |doi= 10.1038/ni913 }}</ref> and by the SKAP1 deficient mouse <ref>Wang H, Liu H, Lu Y, Lovatt M, Wei, B, Rudd CE  Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion, Mol. Cell. Biol. 2007 27, 6863-75. </ref>.  Additional work has implicated SKAP1 in binding to the exchange factor RasGRP1 and in regulating ERK activation in T-cells <ref>*{{cite journal  | author=Kosco KA, Cerignoli F, Williams S, ''et al.'' |title=SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1. |journal=Mol. Immunol. |volume=45 |issue= 2 |pages= 510-22 |year= 2008 |pmid= 17658605 |doi= 10.1016/j.molimm.2007.05.024 }}</ref><ref>Schneider H., Wang H., Raab M., Valk E.,  Smith X. , Lovatt M.,  Wu Z., Strebhardt K, Rudd, CE.  Adaptor SKAP55 binds RasGRP1 and negatively regulates p21ras and the ERK pathway in T-cells. (2008) PLoS ONE. 3, 1718.</ref>.
== Interactions ==


==References==
SKAP1 has been shown to [[Protein-protein interaction|interact]] with [[FYN]],<ref name=pmid9195899 /><ref name=pmid12171928>{{cite journal | vauthors = Wu L, Yu Z, Shen SH | title = SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40420–7 | date = October 2002 | pmid = 12171928 | doi = 10.1074/jbc.M206023200 }}</ref><ref name=pmid9748251>{{cite journal | vauthors = Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA | title = Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 40 | pages = 25789–95 | date = October 1998 | pmid = 9748251 | doi = 10.1074/jbc.273.40.25789 }}</ref> [[PTPRC]]<ref name=pmid11909961>{{cite journal | vauthors = Wu L, Fu J, Shen SH | title = SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2673–86 | date = April 2002 | pmid = 11909961 | pmc = 133720 | doi = 10.1128/MCB.22.8.2673-2686.2002 }}</ref> and [[FYB]].<ref name=pmid9748251/><ref name=pmid9671755>{{cite journal | vauthors = Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE | title = FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8779–84 | date = July 1998 | pmid = 9671755 | pmc = 21153 | doi = 10.1073/pnas.95.15.8779 }}</ref>
{{reflist|2}}


==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Schraven B, Marie-Cardine A, Koretzky G | title = Molecular analysis of the fyn-complex: cloning of SKAP55 and SLAP-130, two novel adaptor proteins which associate with fyn and may participate in the regulation of T cell receptor-mediated signaling | journal = Immunology Letters | volume = 57 | issue = 1-3 | pages = 165–9 | date = June 1997 | pmid = 9232446 | doi = 10.1016/S0165-2478(97)00053-9 }}
| citations =
* {{cite journal | vauthors = Clements JL, Boerth NJ, Lee JR, Koretzky GA | title = Integration of T cell receptor-dependent signaling pathways by adapter proteins | journal = Annual Review of Immunology | volume = 17 | issue =  | pages = 89–108 | year = 1999 | pmid = 10358754 | doi = 10.1146/annurev.immunol.17.1.89 }}
*{{cite journal | author=Schraven B, Marie-Cardine A, Koretzky G |title=Molecular analysis of the fyn-complex: cloning of SKAP55 and SLAP-130, two novel adaptor proteins which associate with fyn and may participate in the regulation of T cell receptor-mediated signaling. |journal=Immunol. Lett. |volume=57 |issue= 1-3 |pages= 165-9 |year= 1997 |pmid= 9232446 |doi= }}
* {{cite journal | vauthors = Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE | title = FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8779–84 | date = July 1998 | pmid = 9671755 | pmc = 21153 | doi = 10.1073/pnas.95.15.8779 }}
*{{cite journal | author=Clements JL, Boerth NJ, Lee JR, Koretzky GA |title=Integration of T cell receptor-dependent signaling pathways by adapter proteins. |journal=Annu. Rev. Immunol. |volume=17 |issue=  |pages= 89-108 |year= 1999 |pmid= 10358754 |doi= 10.1146/annurev.immunol.17.1.89 }}
* {{cite journal | vauthors = Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA | title = Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 40 | pages = 25789–95 | date = October 1998 | pmid = 9748251 | doi = 10.1074/jbc.273.40.25789 }}
*{{cite journal | author=Marie-Cardine A, Bruyns E, Eckerskorn C, ''et al.'' |title=Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16077-80 |year= 1997 |pmid= 9195899 |doi=  }}
* {{cite journal | vauthors = Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T | title = RA70 is a src kinase-associated protein expressed ubiquitously | journal = Biochemical and Biophysical Research Communications | volume = 252 | issue = 3 | pages = 738–42 | date = November 1998 | pmid = 9837776 | doi = 10.1006/bbrc.1998.9637 }}
*{{cite journal  | author=Liu J, Kang H, Raab M, ''et al.'' |title=FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8779-84 |year= 1998 |pmid= 9671755 |doi= }}
* {{cite journal | vauthors = Kang H, Freund C, Duke-Cohan JS, Musacchio A, Wagner G, Rudd CE | title = SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55 | journal = The EMBO Journal | volume = 19 | issue = 12 | pages = 2889–99 | date = June 2000 | pmid = 10856234 | pmc = 203341 | doi = 10.1093/emboj/19.12.2889 }}
*{{cite journal | author=Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, ''et al.'' |title=Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25789-95 |year= 1998 |pmid= 9748251 |doi= }}
* {{cite journal | vauthors = Wu L, Fu J, Shen SH | title = SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2673–86 | date = April 2002 | pmid = 11909961 | pmc = 133720 | doi = 10.1128/MCB.22.8.2673-2686.2002 }}
*{{cite journal | author=Kouroku Y, Soyama A, Fujita E, ''et al.'' |title=RA70 is a src kinase-associated protein expressed ubiquitously. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 3 |pages= 738-42 |year= 1999 |pmid= 9837776 |doi= 10.1006/bbrc.1998.9637 }}
* {{cite journal | vauthors = Wu L, Yu Z, Shen SH | title = SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40420–7 | date = October 2002 | pmid = 12171928 | doi = 10.1074/jbc.M206023200 }}
*{{cite journal | author=Kang H, Freund C, Duke-Cohan JS, ''et al.'' |title=SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55. |journal=EMBO J. |volume=19 |issue= 12 |pages= 2889-99 |year= 2000 |pmid= 10856234 |doi= 10.1093/emboj/19.12.2889 }}
* {{cite journal | vauthors = Huang Y, Norton DD, Precht P, Martindale JL, Burkhardt JK, Wange RL | title = Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells | journal = The Journal of Biological Chemistry | volume = 280 | issue = 25 | pages = 23576–83 | date = June 2005 | pmid = 15849195 | doi = 10.1074/jbc.M413201200 }}
*{{cite journal | author=Wu L, Fu J, Shen SH |title=SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2673-86 |year= 2002 |pmid= 11909961 |doi= }}
* {{cite journal | vauthors = Jo EK, Wang H, Rudd CE | title = An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R | journal = The Journal of Experimental Medicine | volume = 201 | issue = 11 | pages = 1733–9 | date = June 2005 | pmid = 15939789 | pmc = 2213273 | doi = 10.1084/jem.20042577 }}
*{{cite journal | author=Wu L, Yu Z, Shen SH |title=SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40420-7 |year= 2002 |pmid= 12171928 |doi= 10.1074/jbc.M206023200 }}
* {{cite journal | vauthors = Duke-Cohan JS, Kang H, Liu H, Rudd CE | title = Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein | journal = The Journal of Biological Chemistry | volume = 281 | issue = 19 | pages = 13743–50 | date = May 2006 | pmid = 16461356 | doi = 10.1074/jbc.M508774200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kliche S, Breitling D, Togni M, Pusch R, Heuer K, Wang X, Freund C, Kasirer-Friede A, Menasche G, Koretzky GA, Schraven B | title = The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1 | journal = Molecular and Cellular Biology | volume = 26 | issue = 19 | pages = 7130–44 | date = October 2006 | pmid = 16980616 | pmc = 1592884 | doi = 10.1128/MCB.00331-06 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Huang Y, Norton DD, Precht P, ''et al.'' |title=Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells. |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 23576-83 |year= 2005 |pmid= 15849195 |doi= 10.1074/jbc.M413201200 }}
*{{cite journal | author=Jo EK, Wang H, Rudd CE |title=An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R. |journal=J. Exp. Med. |volume=201 |issue= 11 |pages= 1733-9 |year= 2005 |pmid= 15939789 |doi= 10.1084/jem.20042577 }}
*{{cite journal | author=Duke-Cohan JS, Kang H, Liu H, Rudd CE |title=Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein. |journal=J. Biol. Chem. |volume=281 |issue= 19 |pages= 13743-50 |year= 2006 |pmid= 16461356 |doi= 10.1074/jbc.M508774200 }}
*{{cite journal | author=Kliche S, Breitling D, Togni M, ''et al.'' |title=The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. |journal=Mol. Cell. Biol. |volume=26 |issue= 19 |pages= 7130-44 |year= 2006 |pmid= 16980616 |doi= 10.1128/MCB.00331-06 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=8631}}


{{protein-stub}}
{{gene-17-stub}}
{{WikiDoc Sources}}

Latest revision as of 23:07, 19 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene.[1][2]

This gene encodes a T cell adapter protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adapter protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.[2]

The demonstration that SKAP1 regulates LFA-1 adhesion was made by retroviral infection [3] and by the SKAP1 deficient mouse.[4] Additional work has implicated SKAP1 in binding to the exchange factor RasGRP1 and in regulating ERK activation in T-cells.[5][6]

Interactions

SKAP1 has been shown to interact with FYN,[1][7][8] PTPRC[9] and FYB.[8][10]

References

  1. ↑ 1.0 1.1 Marie-Cardine A, Bruyns E, Eckerskorn C, Kirchgessner H, Meuer SC, Schraven B (June 1997). "Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes". The Journal of Biological Chemistry. 272 (26): 16077–80. doi:10.1074/jbc.272.26.16077. PMID 9195899.
  2. ↑ 2.0 2.1 "Entrez Gene: SKAP1 src kinase associated phosphoprotein 1".
  3. ↑ Wang H, Moon EY, Azouz A, Wu X, Smith A, Schneider H, Hogg N, Rudd CE (April 2003). "SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates". Nature Immunology. 4 (4): 366–74. doi:10.1038/ni913. PMID 12652296.
  4. ↑ Wang H, Liu H, Lu Y, Lovatt M, Wei, B, Rudd CE Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion, Mol. Cell. Biol. 2007 27, 6863-75.
  5. ↑ * Kosco KA, Cerignoli F, Williams S, Abraham RT, Mustelin T (January 2008). "SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1". Molecular Immunology. 45 (2): 510–22. doi:10.1016/j.molimm.2007.05.024. PMID 17658605.
  6. ↑ Schneider H., Wang H., Raab M., Valk E., Smith X. , Lovatt M., Wu Z., Strebhardt K, Rudd, CE. Adaptor SKAP55 binds RasGRP1 and negatively regulates p21ras and the ERK pathway in T-cells. (2008) PLoS ONE. 3, 1718.
  7. ↑ Wu L, Yu Z, Shen SH (October 2002). "SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation". The Journal of Biological Chemistry. 277 (43): 40420–7. doi:10.1074/jbc.M206023200. PMID 12171928.
  8. ↑ 8.0 8.1 Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA (October 1998). "Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130". The Journal of Biological Chemistry. 273 (40): 25789–95. doi:10.1074/jbc.273.40.25789. PMID 9748251.
  9. ↑ Wu L, Fu J, Shen SH (April 2002). "SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription". Molecular and Cellular Biology. 22 (8): 2673–86. doi:10.1128/MCB.22.8.2673-2686.2002. PMC 133720. PMID 11909961.
  10. ↑ Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE (July 1998). "FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8779–84. doi:10.1073/pnas.95.15.8779. PMC 21153. PMID 9671755.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=SKAP1&oldid=1418047"