SIPA1: Difference between revisions

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{{Infobox_gene}}
{{GNF_Protein_box
'''Signal-induced proliferation-associated protein 1''' is a [[protein]] that in humans is encoded by the ''SIPA1'' [[gene]].<ref name="pmid9027487">{{cite journal | vauthors = Wada Y, Kubota H, Maeda M, Taniwaki M, Hattori M, Imamura S, Iwai K, Minato N | title = Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human | journal = Genomics | volume = 39 | issue = 1 | pages = 66–73 |date=Mar 1997 | pmid = 9027487 | pmc =  | doi = 10.1006/geno.1996.4464 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIPA1 signal-induced proliferation-associated gene 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6494| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Signal-induced proliferation-associated gene 1
| HGNCid = 10885
| Symbol = SIPA1
| AltSymbols =; MGC102688; MGC17037; SPA1
| OMIM = 602180
| ECnumber = 
| Homologene = 7940
| MGIid = 107576
| Function = {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0046582 |text = Rap GTPase activator activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007162 |text = negative regulation of cell adhesion}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0051056 |text = regulation of small GTPase mediated signal transduction}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6494
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_006738
    | Hs_RefseqmRNA = NM_006747
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 20469
    | Mm_Ensembl = ENSMUSG00000056917
    | Mm_RefseqmRNA = NM_011379
    | Mm_RefseqProtein = NP_035509
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 5651194
    | Mm_GenLoc_end = 5663651
    | Mm_Uniprot = Q3U146
  }}
}}
'''Signal-induced proliferation-associated gene 1''', also known as '''SIPA1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SIPA1 signal-induced proliferation-associated gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6494| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.<ref name="entrez">{{cite web | title = Entrez Gene: SIPA1 signal-induced proliferation-associated gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6494| accessdate = }}</ref>
| summary_text = The product of this gene is a [[mitogen]] induced [[GTPase activating protein]] (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins [[Rap1]] and Rap2, but not for Ran or other [[small GTPases]]. This protein may also hamper mitogen-induced [[cell cycle]] progression when abnormally or prematurely [[gene expression|expressed.]] It is localized to the [[cell nucleus|perinuclear region]]. Two alternatively spliced variants encoding the same [[isoform]] have been characterized to date.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Minato N |title=[Regulatory mechanisms of lymphocyte proliferation: roles of Spa-1 gene] |journal=Hum. Cell |volume=9 |issue= 1 |pages= 11-6 |year= 1997 |pmid= 9183624 |doi=  }}
*{{cite journal  | author=Minato N |title=[Regulatory mechanisms of lymphocyte proliferation: roles of Spa-1 gene] |journal=Hum. Cell |volume=9 |issue= 1 |pages= 11–6 |year= 1997 |pmid= 9183624 |doi=  }}
*{{cite journal | author=Hattori M, Tsukamoto N, Nur-e-Kamal MS, ''et al.'' |title=Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. |journal=Mol. Cell. Biol. |volume=15 |issue= 1 |pages= 552-60 |year= 1995 |pmid= 7799964 |doi=  }}
*{{cite journal   |vauthors=Hattori M, Tsukamoto N, Nur-e-Kamal MS, etal |title=Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression |journal=Mol. Cell. Biol. |volume=15 |issue= 1 |pages= 552–60 |year= 1995 |pmid= 7799964 |doi= | pmc=232010 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
*{{cite journal  | author=Wada Y, Kubota H, Maeda M, ''et al.'' |title=Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human. |journal=Genomics |volume=39 |issue= 1 |pages= 66-73 |year= 1997 |pmid= 9027487 |doi= 10.1006/geno.1996.4464 }}
*{{cite journal   |vauthors=Kurachi H, Wada Y, Tsukamoto N, etal |title=Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 28081–8 |year= 1997 |pmid= 9346962 |doi=10.1074/jbc.272.44.28081 }}
*{{cite journal | author=Kurachi H, Wada Y, Tsukamoto N, ''et al.'' |title=Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 28081-8 |year= 1997 |pmid= 9346962 |doi=  }}
*{{cite journal   |vauthors=Ebrahimi S, Wang E, Udar N, etal |title=Genomic organization and cloning of the human homologue of murine Sipa-1 |journal=Gene |volume=214 |issue= 1–2 |pages= 215–21 |year= 1998 |pmid= 9651531 |doi=10.1016/S0378-1119(98)00212-1 }}
*{{cite journal | author=Ebrahimi S, Wang E, Udar N, ''et al.'' |title=Genomic organization and cloning of the human homologue of murine Sipa-1. |journal=Gene |volume=214 |issue= 1-2 |pages= 215-21 |year= 1998 |pmid= 9651531 |doi=  }}
*{{cite journal   |vauthors=Tsukamoto N, Hattori M, Yang H, etal |title=Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18463–9 |year= 1999 |pmid= 10373454 |doi=10.1074/jbc.274.26.18463 }}
*{{cite journal | author=Tsukamoto N, Hattori M, Yang H, ''et al.'' |title=Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18463-9 |year= 1999 |pmid= 10373454 |doi=  }}
*{{cite journal  | vauthors=Hoecker U, Quail PH |title=The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis |journal=J. Biol. Chem. |volume=276 |issue= 41 |pages= 38173–8 |year= 2001 |pmid= 11461903 |doi= 10.1074/jbc.M103140200 }}
*{{cite journal  | author=Hoecker U, Quail PH |title=The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis. |journal=J. Biol. Chem. |volume=276 |issue= 41 |pages= 38173-8 |year= 2001 |pmid= 11461903 |doi= 10.1074/jbc.M103140200 }}
*{{cite journal   |vauthors=Roy BC, Kohu K, Matsuura K, etal |title=SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus |journal=Genes Cells |volume=7 |issue= 6 |pages= 607–17 |year= 2003 |pmid= 12059963 |doi=10.1046/j.1365-2443.2002.00546.x }}
*{{cite journal | author=Roy BC, Kohu K, Matsuura K, ''et al.'' |title=SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus. |journal=Genes Cells |volume=7 |issue= 6 |pages= 607-17 |year= 2003 |pmid= 12059963 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Farina A, Hattori M, Qin J, etal |title=Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity and Subcellular Localization |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9059–69 |year= 2004 |pmid= 15456879 |doi= 10.1128/MCB.24.20.9059-9069.2004 | pmc=517877 }}
*{{cite journal | author=Farina A, Hattori M, Qin J, ''et al.'' |title=Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9059-69 |year= 2004 |pmid= 15456879 |doi= 10.1128/MCB.24.20.9059-9069.2004 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Crawford NP, Ziogas A, Peel DJ, etal |title=Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer |journal=Breast Cancer Res. |volume=8 |issue= 2 |pages= R16 |year= 2006 |pmid= 16563182 |doi= 10.1186/bcr1389 | pmc=1483843 }}
*{{cite journal | author=Crawford NP, Ziogas A, Peel DJ, ''et al.'' |title=Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. |journal=Breast Cancer Res. |volume=8 |issue= 2 |pages= R16 |year= 2006 |pmid= 16563182 |doi= 10.1186/bcr1389 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 21:29, 19 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.[1][2]

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.[2]

References

  1. ↑ Wada Y, Kubota H, Maeda M, Taniwaki M, Hattori M, Imamura S, Iwai K, Minato N (Mar 1997). "Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human". Genomics. 39 (1): 66–73. doi:10.1006/geno.1996.4464. PMID 9027487.
  2. ↑ 2.0 2.1 "Entrez Gene: SIPA1 signal-induced proliferation-associated gene 1".

Further reading



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