SHB (gene)

Src homology 2 domain containing adaptor protein B
Identifiers
Symbols	SHB ; RP11-3J10.8; bA3J10.2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74458
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SHB 204657 s at tn.png
File:PBB GE SHB 204656 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Src homology 2 domain containing adaptor protein B, also known as SHB, is a human gene.

Further reading

• Karlsson T, Songyang Z, Landgren E; et al. (1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475–83. PMID 7537362.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yulug IG, Hillermann R, Fisher EM (1995). "The SHB adaptor protein maps to human chromosome 9". Genomics. 24 (3): 615–7. doi:10.1006/geno.1994.1681. PMID 7713524.CS1 maint: Multiple names: authors list (link)
• Welsh M, Mares J, Karlsson T; et al. (1994). "Shb is a ubiquitously expressed Src homology 2 protein". Oncogene. 9 (1): 19–27. PMID 8302579.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karlsson T, Welsh M (1996). "Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb". Oncogene. 13 (5): 955–61. PMID 8806685.
• Welsh M, Songyang Z, Frantz JD; et al. (1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins". Oncogene. 16 (7): 891–901. doi:10.1038/sj.onc.1201607. PMID 9484780.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karlsson T, Kullander K, Welsh M (1998). "The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells". Cell Growth Differ. 9 (9): 757–66. PMID 9751119.CS1 maint: Multiple names: authors list (link)
• Lindholm CK, Gylfe E, Zhang W; et al. (1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells". J. Biol. Chem. 274 (39): 28050–7. PMID 10488157.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dixelius J, Larsson H, Sasaki T; et al. (2000). "Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis". Blood. 95 (11): 3403–11. PMID 10828022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hooshmand-Rad R, Lu L, Heldin CH; et al. (2000). "Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization". Exp. Cell Res. 257 (2): 245–54. doi:10.1006/excr.2000.4896. PMID 10837138.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu L, Annerén C, Reedquist KA; et al. (2000). "NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway". Exp. Cell Res. 259 (2): 370–7. doi:10.1006/excr.2000.4984. PMID 10964504.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Diakonova M, Gunter DR, Herrington J, Carter-Su C (2002). "SH2-Bbeta is a Rac-binding protein that regulates cell motility". J. Biol. Chem. 277 (12): 10669–77. doi:10.1074/jbc.M111138200. PMID 11786545.CS1 maint: Multiple names: authors list (link)
• Lindholm CK, Henriksson ML, Hallberg B, Welsh M (2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". Eur. J. Biochem. 269 (13): 3279–88. PMID 12084069.CS1 maint: Multiple names: authors list (link)
• Cross MJ, Lu L, Magnusson P; et al. (2003). "The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells". Mol. Biol. Cell. 13 (8): 2881–93. doi:10.1091/mbc.E02-02-0103. PMID 12181353.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lindholm CK (2002). "IL-2 receptor signaling through the Shb adapter protein in T and NK cells". Biochem. Biophys. Res. Commun. 296 (4): 929–36. PMID 12200137.
• Holmqvist K, Cross M, Riley D, Welsh M (2003). "The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells". Cell. Signal. 15 (2): 171–9. PMID 12464388.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Welsh N, Makeeva N, Welsh M (2003). "Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins". Mol. Med. 8 (11): 695–704. PMID 12520086.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holmqvist K, Cross MJ, Rolny C; et al. (2004). "The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration". J. Biol. Chem. 279 (21): 22267–75. doi:10.1074/jbc.M312729200. PMID 15026417.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)