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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''SH2B adapter protein 1''' is a [[protein]] that in humans is encoded by the ''SH2B1'' [[gene]].<ref name="pmid11827956">{{cite journal | vauthors = Kong M, Wang CS, Donoghue DJ | title = Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation | journal = J Biol Chem | volume = 277 | issue = 18 | pages = 15962–70 | date = Apr 2002 | pmid = 11827956 | pmc =  | doi = 10.1074/jbc.M102777200 }}</ref><ref name="pmid10594240">{{cite journal | vauthors = Nelms K, O'Neill TJ, Li S, Hubbard SR, Gustafson TA, Paul WE | title = Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain | journal = Mamm Genome | volume = 10 | issue = 12 | pages = 1160–7 | date = Jan 2000 | pmid = 10594240 | pmc =  | doi = 10.1007/s003359901183 | url = https://zenodo.org/record/1232697/files/article.pdf }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SH2B1 SH2B adaptor protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25970| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_SH2B1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hdv.
| PDB = {{PDB2|2hdv}}, {{PDB2|2hdx}}
| Name = SH2B adaptor protein 1
| HGNCid = 30417
| Symbol = SH2B1
| AltSymbols =; DKFZp547G1110; FLJ30542; SH2-B; SH2B
| OMIM = 608937
| ECnumber = 
| Homologene = 32122
| MGIid = 1201407
| GeneAtlas_image1 = PBB_GE_SH2B1_209322_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SH2B1_40149_at_tn.png
| Function =
| Component =
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 25970
    | Hs_Ensembl = ENSG00000178188
    | Hs_RefseqProtein = NP_056318
    | Hs_RefseqmRNA = NM_015503
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 28765511
    | Hs_GenLoc_end = 28793027
    | Hs_Uniprot = 
    | Mm_EntrezGene = 20399
    | Mm_Ensembl = ENSMUSG00000030733
    | Mm_RefseqmRNA = NM_001081459
    | Mm_RefseqProtein = NP_001074928
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 126258148
    | Mm_GenLoc_end = 126266198
    | Mm_Uniprot = 
  }}
}}
'''SH2B adaptor protein 1''', also known as '''SH2B1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SH2B1 SH2B adaptor protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25970| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
SH2B1 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[Grb2]],<ref name = "pmid9856458">{{cite journal | vauthors = Qian X, Riccio A, Zhang Y, Ginty DD | title = Identification and characterization of novel substrates of Trk receptors in developing neurons | journal = Neuron | volume = 21 | issue = 5 | pages = 1017–29 | date = November 1998 | pmid = 9856458 | doi =  10.1016/s0896-6273(00)80620-0}}</ref><ref name = pmid9742218/>
| section_title =  
* [[Insulin receptor]],<ref name = "pmid10594240"/><ref name = "pmid9742218">{{cite journal | vauthors = Kotani K, Wilden P, Pillay TS | title = SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase | journal = Biochem. J. | volume = 335 | issue =  1| pages = 103–9 | date = October 1998 | pmid = 9742218 | pmc = 1219757 | doi =  10.1042/bj3350103 }}</ref>
| summary_text =  
* [[Janus kinase 2]],<ref name = "pmid9343427">{{cite journal | vauthors = Rui L, Mathews LS, Hotta K, Gustafson TA, Carter-Su C | title = Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling | journal = Mol. Cell. Biol. | volume = 17 | issue = 11 | pages = 6633–44 | date = November 1997 | pmid = 9343427 | pmc = 232517 | doi = 10.1128/mcb.17.11.6633}}</ref><ref name = "pmid12370803">{{cite journal | vauthors = Xie S, Lin H, Sun T, Arlinghaus RB | title = Jak2 is involved in c-Myc induction by Bcr-Abl | journal = Oncogene | volume = 21 | issue = 47 | pages = 7137–46 | date = October 2002 | pmid = 12370803 | doi = 10.1038/sj.onc.1205942 }}</ref> and
}}
* [[TrkA]].<ref name = pmid9856458/><ref name = "pmid10708759">{{cite journal | vauthors = Koch A, Mancini A, Stefan M, Niedenthal R, Niemann H, Tamura T | title = Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop | journal = FEBS Lett. | volume = 469 | issue = 1 | pages = 72–6 | date = March 2000 | pmid = 10708759 | doi = 10.1016/s0014-5793(00)01242-4}}</ref>


==References==
== Clinical significance ==
{{reflist|2}}
 
==Further reading==
Variations close to or in the SH2B1 gene have been found to associatate with [[obesity]] in two very large genome wide association studies of [[body mass index]] (BMI).<ref name="pmid19079260">{{cite journal | vauthors = Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, Styrkarsdottir U, Gretarsdottir S, Thorlacius S, Jonsdottir I, Jonsdottir T, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Jonsson F, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Lauritzen T, Aben KK, Verbeek AL, Roeleveld N, Kampman E, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Becker DM, Gulcher J, Kiemeney LA, Pedersen O, Kong A, Thorsteinsdottir U, Stefansson K | title = Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. | journal = Nat. Genet. | volume = 41 | issue = 1 | pages = 18–24 | date = January 2009 | pmid = 19079260 | doi = 10.1038/ng.274 }}</ref><ref name="pmid19079261">{{cite journal | vauthors = Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN | title = Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. | journal = Nat. Genet. | volume = 41 | issue = 1 | pages = 24–34 | date = January 2009 | pmid = 19079261 | pmc = 2695662 | doi = 10.1038/ng.287 }}</ref> Furthermore, SH2B1 deletions are associated with severe early-onset obesity.<ref name="pmid19966786">{{cite journal | vauthors = Bochukova EG, Huang N, Keogh J, Henning E, Purmann C, Blaszczyk K, Saeed S, Hamilton-Shield J, Clayton-Smith J, O'Rahilly S, Hurles ME, Farooqi IS | title = Large, rare chromosomal deletions associated with severe early-onset obesity | journal = Nature | volume = 463 | issue = 7281 | pages = 666–70 | date = February 2010 | pmid = 19966786 | pmc = 3108883 | doi = 10.1038/nature08689 }}</ref>
 
== See also ==
* [[Genetics of obesity]]
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rui L, Mathews LS, Hotta K, Gustafson TA, Carter-Su C | title = Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling. | journal = Mol. Cell. Biol. | volume = 17 | issue = 11 | pages = 6633–44 | year = 1997 | pmid = 9343427 | pmc = 232517 | doi =  10.1128/mcb.17.11.6633}}
| citations =
* {{cite journal | vauthors = Kotani K, Wilden P, Pillay TS | title = SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase. | journal = Biochem. J. | volume = 335 | issue =  | pages = 103–9 | year = 1998 | pmid = 9742218 | pmc = 1219757 | doi =  10.1042/bj3350103 }}
*{{cite journal | author=Rui L, Mathews LS, Hotta K, ''et al.'' |title=Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6633-44 |year= 1997 |pmid= 9343427 |doi=  }}
* {{cite journal | vauthors = Qian X, Riccio A, Zhang Y, Ginty DD | title = Identification and characterization of novel substrates of Trk receptors in developing neurons. | journal = Neuron | volume = 21 | issue = 5 | pages = 1017–29 | year = 1999 | pmid = 9856458 | doi = 10.1016/S0896-6273(00)80620-0 }}
*{{cite journal | author=Kotani K, Wilden P, Pillay TS |title=SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase. |journal=Biochem. J. |volume=335 ( Pt 1) |issue=  |pages= 103-9 |year= 1998 |pmid= 9742218 |doi=  }}
* {{cite journal | vauthors = Koch A, Mancini A, Stefan M, Niedenthal R, Niemann H, Tamura T | title = Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop. | journal = FEBS Lett. | volume = 469 | issue = 1 | pages = 72–6 | year = 2000 | pmid = 10708759 | doi = 10.1016/S0014-5793(00)01242-4 }}
*{{cite journal | author=Qian X, Riccio A, Zhang Y, Ginty DD |title=Identification and characterization of novel substrates of Trk receptors in developing neurons. |journal=Neuron |volume=21 |issue= 5 |pages= 1017-29 |year= 1999 |pmid= 9856458 |doi= }}
* {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. | journal = DNA Res. | volume = 7 | issue = 1 | pages = 65–73 | year = 2000 | pmid = 10718198 | doi = 10.1093/dnares/7.1.65 }}
*{{cite journal  | author=Nelms K, O'Neill TJ, Li S, ''et al.'' |title=Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain. |journal=Mamm. Genome |volume=10 |issue= 12 |pages= 1160-7 |year= 2000 |pmid= 10594240 |doi=  }}
* {{cite journal | vauthors = Rui L, Gunter DR, Herrington J, Carter-Su C | title = Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta. | journal = Mol. Cell. Biol. | volume = 20 | issue = 9 | pages = 3168–77 | year = 2000 | pmid = 10757801 | pmc = 85611 | doi = 10.1128/MCB.20.9.3168-3177.2000 }}
*{{cite journal | author=Koch A, Mancini A, Stefan M, ''et al.'' |title=Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop. |journal=FEBS Lett. |volume=469 |issue= 1 |pages= 72-6 |year= 2000 |pmid= 10708759 |doi= }}
* {{cite journal | vauthors = O'Brien KB, O'Shea JJ, Carter-Su C | title = SH2-B family members differentially regulate JAK family tyrosine kinases. | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8673–81 | year = 2002 | pmid = 11751854 | doi = 10.1074/jbc.M109165200 }}
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65-73 |year= 2000 |pmid= 10718198 |doi= }}
* {{cite journal | vauthors = Ohtsuka S, Takaki S, Iseki M, Miyoshi K, Nakagata N, Kataoka Y, Yoshida N, Takatsu K, Yoshimura A | title = SH2-B is required for both male and female reproduction. | journal = Mol. Cell. Biol. | volume = 22 | issue = 9 | pages = 3066–77 | year = 2002 | pmid = 11940664 | pmc = 133757 | doi = 10.1128/MCB.22.9.3066-3077.2002 }}
*{{cite journal | author=Rui L, Gunter DR, Herrington J, Carter-Su C |title=Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta. |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 3168-77 |year= 2000 |pmid= 10757801 |doi= }}
* {{cite journal | vauthors = Xie S, Lin H, Sun T, Arlinghaus RB | title = Jak2 is involved in c-Myc induction by Bcr-Abl. | journal = Oncogene | volume = 21 | issue = 47 | pages = 7137–46 | year = 2002 | pmid = 12370803 | doi = 10.1038/sj.onc.1205942 }}
*{{cite journal | author=O'Brien KB, O'Shea JJ, Carter-Su C |title=SH2-B family members differentially regulate JAK family tyrosine kinases. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8673-81 |year= 2002 |pmid= 11751854 |doi= 10.1074/jbc.M109165200 }}
* {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. | journal = Genome Res. | volume = 12 | issue = 11 | pages = 1773–84 | year = 2003 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
*{{cite journal | author=Kong M, Wang CS, Donoghue DJ |title=Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15962-70 |year= 2002 |pmid= 11827956 |doi= 10.1074/jbc.M102777200 }}
* {{cite journal | vauthors = O'Brien KB, Argetsinger LS, Diakonova M, Carter-Su C | title = YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling. | journal = J. Biol. Chem. | volume = 278 | issue = 14 | pages = 11970–8 | year = 2003 | pmid = 12551917 | doi = 10.1074/jbc.M210765200 }}
*{{cite journal  | author=Ohtsuka S, Takaki S, Iseki M, ''et al.'' |title=SH2-B is required for both male and female reproduction. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 3066-77 |year= 2002 |pmid= 11940664 |doi= }}
* {{cite journal | vauthors = Nishi M, Werner ED, Oh BC, Frantz JD, Dhe-Paganon S, Hansen L, Lee J, Shoelson SE | title = Kinase activation through dimerization by human SH2-B. | journal = Mol. Cell. Biol. | volume = 25 | issue = 7 | pages = 2607–21 | year = 2005 | pmid = 15767667 | pmc = 1061652 | doi = 10.1128/MCB.25.7.2607-2621.2005 }}
*{{cite journal | author=Xie S, Lin H, Sun T, Arlinghaus RB |title=Jak2 is involved in c-Myc induction by Bcr-Abl. |journal=Oncogene |volume=21 |issue= 47 |pages= 7137-46 |year= 2002 |pmid= 12370803 |doi= 10.1038/sj.onc.1205942 }}
* {{cite journal | vauthors = Donatello S, Fiorino A, Degl'Innocenti D, Alberti L, Miranda C, Gorla L, Bongarzone I, Rizzetti MG, Pierotti MA, Borrello MG | title = SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling. | journal = Oncogene | volume = 26 | issue = 45 | pages = 6546–59 | year = 2007 | pmid = 17471236 | doi = 10.1038/sj.onc.1210480 }}
*{{cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=O'Brien KB, Argetsinger LS, Diakonova M, Carter-Su C |title=YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling. |journal=J. Biol. Chem. |volume=278 |issue= 14 |pages= 11970-8 |year= 2003 |pmid= 12551917 |doi= 10.1074/jbc.M210765200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Nishi M, Werner ED, Oh BC, ''et al.'' |title=Kinase activation through dimerization by human SH2-B. |journal=Mol. Cell. Biol. |volume=25 |issue= 7 |pages= 2607-21 |year= 2005 |pmid= 15767667 |doi= 10.1128/MCB.25.7.2607-2621.2005 }}
*{{cite journal | author=Donatello S, Fiorino A, Degl'Innocenti D, ''et al.'' |title=SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling. |journal=Oncogene |volume=26 |issue= 45 |pages= 6546-59 |year= 2007 |pmid= 17471236 |doi= 10.1038/sj.onc.1210480 }}
}}
{{refend}}
{{refend}}
 
{{PDB Gallery|geneid=25970}}
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Latest revision as of 09:25, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SH2B adapter protein 1 is a protein that in humans is encoded by the SH2B1 gene.[1][2][3]

Interactions

SH2B1 has been shown to interact with:

Clinical significance

Variations close to or in the SH2B1 gene have been found to associatate with obesity in two very large genome wide association studies of body mass index (BMI).[9][10] Furthermore, SH2B1 deletions are associated with severe early-onset obesity.[11]

See also

References

  1. ↑ Kong M, Wang CS, Donoghue DJ (Apr 2002). "Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation". J Biol Chem. 277 (18): 15962–70. doi:10.1074/jbc.M102777200. PMID 11827956.
  2. ↑ 2.0 2.1 Nelms K, O'Neill TJ, Li S, Hubbard SR, Gustafson TA, Paul WE (Jan 2000). "Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain" (PDF). Mamm Genome. 10 (12): 1160–7. doi:10.1007/s003359901183. PMID 10594240.
  3. ↑ "Entrez Gene: SH2B1 SH2B adaptor protein 1".
  4. ↑ 4.0 4.1 Qian X, Riccio A, Zhang Y, Ginty DD (November 1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. doi:10.1016/s0896-6273(00)80620-0. PMID 9856458.
  5. ↑ 5.0 5.1 Kotani K, Wilden P, Pillay TS (October 1998). "SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase". Biochem. J. 335 (1): 103–9. doi:10.1042/bj3350103. PMC 1219757. PMID 9742218.
  6. ↑ Rui L, Mathews LS, Hotta K, Gustafson TA, Carter-Su C (November 1997). "Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling". Mol. Cell. Biol. 17 (11): 6633–44. doi:10.1128/mcb.17.11.6633. PMC 232517. PMID 9343427.
  7. ↑ Xie S, Lin H, Sun T, Arlinghaus RB (October 2002). "Jak2 is involved in c-Myc induction by Bcr-Abl". Oncogene. 21 (47): 7137–46. doi:10.1038/sj.onc.1205942. PMID 12370803.
  8. ↑ Koch A, Mancini A, Stefan M, Niedenthal R, Niemann H, Tamura T (March 2000). "Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop". FEBS Lett. 469 (1): 72–6. doi:10.1016/s0014-5793(00)01242-4. PMID 10708759.
  9. ↑ Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, Styrkarsdottir U, Gretarsdottir S, Thorlacius S, Jonsdottir I, Jonsdottir T, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Jonsson F, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Lauritzen T, Aben KK, Verbeek AL, Roeleveld N, Kampman E, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Becker DM, Gulcher J, Kiemeney LA, Pedersen O, Kong A, Thorsteinsdottir U, Stefansson K (January 2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID 19079260.
  10. ↑ Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 24–34. doi:10.1038/ng.287. PMC 2695662. PMID 19079261.
  11. ↑ Bochukova EG, Huang N, Keogh J, Henning E, Purmann C, Blaszczyk K, Saeed S, Hamilton-Shield J, Clayton-Smith J, O'Rahilly S, Hurles ME, Farooqi IS (February 2010). "Large, rare chromosomal deletions associated with severe early-onset obesity". Nature. 463 (7281): 666–70. doi:10.1038/nature08689. PMC 3108883. PMID 19966786.

Further reading

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