SERPINB9

Serpin peptidase inhibitor, clade B (ovalbumin), member 9
Identifiers
Symbols	SERPINB9 ; CAP-3; CAP3; PI9
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37888
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SERPINB9 209723 at tn.png
File:PBB GE SERPINB9 209722 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Serpin peptidase inhibitor, clade B (ovalbumin), member 9, also known as SERPINB9, is a human gene.

PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM]

See also

• Serpin

Further reading

• Sprecher CA, Morgenstern KA, Mathewes S; et al. (1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J. Biol. Chem. 270 (50): 29854–61. PMID 8530382.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun J, Bird CH, Sutton V; et al. (1996). "A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes". J. Biol. Chem. 271 (44): 27802–9. PMID 8910377.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun J, Stephens R, Mirza G; et al. (1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet. Cell Genet. 82 (3–4): 273–7. PMID 9858835.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Annand RR, Dahlen JR, Sprecher CA; et al. (1999). "Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9". Biochem. J. 342 Pt 3: 655–65. PMID 10477277.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kanamori H, Krieg S, Mao C; et al. (2000). "Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells". J. Biol. Chem. 275 (8): 5867–73. PMID 10681578.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bladergroen BA, Strik MC, Bovenschen N; et al. (2001). "The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites". J. Immunol. 166 (5): 3218–25. PMID 11207275.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Buzza MS, Hirst CE, Bird CH; et al. (2001). "The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses". Cell. Immunol. 210 (1): 21–9. doi:10.1006/cimm.2001.1806. PMID 11485349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirst CE, Buzza MS, Sutton VR; et al. (2002). "Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction". Mol. Hum. Reprod. 7 (12): 1133–42. PMID 11719590.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka K, Harashima N, Niiya F; et al. (2002). "Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients". Jpn. J. Cancer Res. 93 (2): 198–208. PMID 11856484.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• ten Berge RL, Meijer CJ, Dukers DF; et al. (2002). "Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma". Blood. 99 (12): 4540–6. PMID 12036886.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirst CE, Buzza MS, Bird CH; et al. (2003). "The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency". J. Immunol. 170 (2): 805–15. PMID 12517944.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rowshani AT, Florquin S, Bemelman F; et al. (2005). "Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection". Kidney Int. 66 (4): 1417–22. doi:10.1111/j.1523-1755.2004.00903.x. PMID 15458434.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mahrus S, Kisiel W, Craik CS (2005). "Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B.". J. Biol. Chem. 279 (52): 54275–82. doi:10.1074/jbc.M411482200. PMID 15494398.CS1 maint: Multiple names: authors list (link)
• Classen CF, Ushmorov A, Bird P, Debatin KM (2006). "The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias". Haematologica. 89 (11): 1314–21. PMID 15531453.CS1 maint: Multiple names: authors list (link)
• Bruneel A, Labas V, Mailloux A; et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Houdt IS, Oudejans JJ, van den Eertwegh AJ; et al. (2005). "Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma". Clin. Cancer Res. 11 (17): 6400–7. doi:10.1158/1078-0432.CCR-05-0306. PMID 16144945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• SERPINB9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.