SENP6

SUMO1/sentrin specific peptidase 6
Identifiers
Symbols	SENP6 ; KIAA0389; FLJ11355; FLJ11887; KIAA0797; SSP1; SUSP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 9196
Gene ontology Molecular function Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SENP6 202318 s at tn.png
File:PBB GE SENP6 202319 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SUMO1/sentrin specific peptidase 6, also known as SENP6, is a human gene.

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000).[supplied by OMIM]

Further reading

• Yeh ET, Gong L, Kamitani T (2000). "Ubiquitin-like proteins: new wines in new bottles". Gene. 248 (1–2): 1–14. PMID 10806345.CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. PMID 9872452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim KI, Baek SH, Jeon YJ; et al. (2000). "A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs". J. Biol. Chem. 275 (19): 14102–6. PMID 10799485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goodson ML, Hong Y, Rogers R; et al. (2001). "Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor". J. Biol. Chem. 276 (21): 18513–8. doi:10.1074/jbc.M008066200. PMID 11278381.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tojo M, Matsuzaki K, Minami T; et al. (2003). "The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system". J. Biol. Chem. 277 (48): 46576–85. doi:10.1074/jbc.M205987200. PMID 12354770.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bailey D, O'Hare P (2004). "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1". J. Biol. Chem. 279 (1): 692–703. doi:10.1074/jbc.M306195200. PMID 14563852.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Choi SJ, Chung SS, Rho EJ; et al. (2006). "Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1". J. Biol. Chem. 281 (41): 30669–77. doi:10.1074/jbc.M604033200. PMID 16912044.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mukhopadhyay D, Ayaydin F, Kolli N; et al. (2006). "SUSP1 antagonizes formation of highly SUMO2/3-conjugated species". J. Cell Biol. 174 (7): 939–49. doi:10.1083/jcb.200510103. PMID 17000875.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)