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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Sentrin-specific protease 6''' is an [[enzyme]] that in humans is encoded by the ''SENP6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SENP6 SUMO1/sentrin specific peptidase 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26054| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SUMO1/sentrin specific peptidase 6
| HGNCid = 20944
| Symbol = SENP6
| AltSymbols =; KIAA0389; FLJ11355; FLJ11887; KIAA0797; SSP1; SUSP1
| OMIM = 605003
| ECnumber = 
| Homologene = 9196
| MGIid = 1922075
| GeneAtlas_image1 = PBB_GE_SENP6_202318_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SENP6_202319_at_tn.png
| Function = {{GNF_GO|id=GO:0008234 |text = cysteine-type peptidase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26054
    | Hs_Ensembl = ENSG00000112701
    | Hs_RefseqProtein = NP_056386
    | Hs_RefseqmRNA = NM_015571
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 76367945
    | Hs_GenLoc_end = 76483649
    | Hs_Uniprot = Q9GZR1
    | Mm_EntrezGene = 215351
    | Mm_Ensembl = ENSMUSG00000034252
    | Mm_RefseqmRNA = XM_918313
    | Mm_RefseqProtein = XP_923406
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 79852657
    | Mm_GenLoc_end = 79930464
    | Mm_Uniprot = Q6P7W0
  }}
}}
'''SUMO1/sentrin specific peptidase 6''', also known as '''SENP6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SENP6 SUMO1/sentrin specific peptidase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26054| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Ubiquitin-like molecules (UBLs), such as [[Small ubiquitin-related modifier 1|SUMO1]], are structurally related to [[ubiquitin]] and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of [[RANGAP1]] to the [[nuclear pore complex]], as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S [[proteasome]]. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal [[glycine]]-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins
{{PBB_Summary
| section_title =
| summary_text = Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SENP6 SUMO1/sentrin specific peptidase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26054| accessdate = }}</ref>
}}


==References==
== See also ==
{{reflist|2}}
*[[small ubiquitin-related modifier 1]]
==Further reading==
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS | title = Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs | journal = The Journal of Biological Chemistry | volume = 282 | issue = 36 | pages = 26217–24 | date = September 2007 | pmid = 17591783 | doi = 10.1074/jbc.M702444200 }}
| citations =  
* {{cite journal | vauthors = Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS | title = Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family | journal = The Biochemical Journal | volume = 409 | issue = 2 | pages = 461–9 | date = January 2008 | pmid = 17916063 | doi = 10.1042/BJ20070940 }}
*{{cite journal | author=Yeh ET, Gong L, Kamitani T |title=Ubiquitin-like proteins: new wines in new bottles. |journal=Gene |volume=248 |issue= 1-2 |pages= 1-14 |year= 2000 |pmid= 10806345 |doi= }}
* {{cite journal | vauthors = Yeh ET, Gong L, Kamitani T | title = Ubiquitin-like proteins: new wines in new bottles | journal = Gene | volume = 248 | issue = 1-2 | pages = 1–14 | date = May 2000 | pmid = 10806345 | doi = 10.1016/S0378-1119(00)00139-6 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi= }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 5 | pages = 277–86 | date = October 1998 | pmid = 9872452 | doi = 10.1093/dnares/5.5.277 }}
*{{cite journal | author=Kim KI, Baek SH, Jeon YJ, ''et al.'' |title=A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14102-6 |year= 2000 |pmid= 10799485 |doi= }}
* {{cite journal | vauthors = Kim KI, Baek SH, Jeon YJ, Nishimori S, Suzuki T, Uchida S, Shimbara N, Saitoh H, Tanaka K, Chung CH | title = A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs | journal = The Journal of Biological Chemistry | volume = 275 | issue = 19 | pages = 14102–6 | date = May 2000 | pmid = 10799485 | doi = 10.1074/jbc.275.19.14102 }}
*{{cite journal | author=Goodson ML, Hong Y, Rogers R, ''et al.'' |title=Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 18513-8 |year= 2001 |pmid= 11278381 |doi= 10.1074/jbc.M008066200 }}
* {{cite journal | vauthors = Goodson ML, Hong Y, Rogers R, Matunis MJ, Park-Sarge OK, Sarge KD | title = Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 18513–8 | date = May 2001 | pmid = 11278381 | doi = 10.1074/jbc.M008066200 }}
*{{cite journal | author=Tojo M, Matsuzaki K, Minami T, ''et al.'' |title=The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46576-85 |year= 2003 |pmid= 12354770 |doi= 10.1074/jbc.M205987200 }}
* {{cite journal | vauthors = Tojo M, Matsuzaki K, Minami T, Honda Y, Yasuda H, Chiba T, Saya H, Fujii-Kuriyama Y, Nakao M | title = The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system | journal = The Journal of Biological Chemistry | volume = 277 | issue = 48 | pages = 46576–85 | date = November 2002 | pmid = 12354770 | doi = 10.1074/jbc.M205987200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Bailey D, O'Hare P | title = Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 1 | pages = 692–703 | date = January 2004 | pmid = 14563852 | doi = 10.1074/jbc.M306195200 }}
*{{cite journal  | author=Bailey D, O'Hare P |title=Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1. |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 692-703 |year= 2004 |pmid= 14563852 |doi= 10.1074/jbc.M306195200 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
* {{cite journal | vauthors = Choi SJ, Chung SS, Rho EJ, Lee HW, Lee MH, Choi HS, Seol JH, Baek SH, Bang OS, Chung CH | title = Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 41 | pages = 30669–77 | date = October 2006 | pmid = 16912044 | doi = 10.1074/jbc.M604033200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Mukhopadhyay D, Ayaydin F, Kolli N, Tan SH, Anan T, Kametaka A, Azuma Y, Wilkinson KD, Dasso M | title = SUSP1 antagonizes formation of highly SUMO2/3-conjugated species | journal = The Journal of Cell Biology | volume = 174 | issue = 7 | pages = 939–49 | date = September 2006 | pmid = 17000875 | pmc = 2064386 | doi = 10.1083/jcb.200510103 | url = https://kuscholarworks.ku.edu/bitstream/1808/15208/1/AzumaY_2006.pdf }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Choi SJ, Chung SS, Rho EJ, ''et al.'' |title=Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 30669-77 |year= 2006 |pmid= 16912044 |doi= 10.1074/jbc.M604033200 }}
*{{cite journal | author=Mukhopadhyay D, Ayaydin F, Kolli N, ''et al.'' |title=SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. |journal=J. Cell Biol. |volume=174 |issue= 7 |pages= 939-49 |year= 2006 |pmid= 17000875 |doi= 10.1083/jcb.200510103 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-6-stub}}
{{WikiDoc Sources}}

Latest revision as of 14:15, 4 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene.[1]

Function

Ubiquitin-like molecules (UBLs), such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins

See also

References

  1. ↑ "Entrez Gene: SENP6 SUMO1/sentrin specific peptidase 6".

Further reading

  • Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS (September 2007). "Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs". The Journal of Biological Chemistry. 282 (36): 26217–24. doi:10.1074/jbc.M702444200. PMID 17591783.
  • Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS (January 2008). "Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family". The Biochemical Journal. 409 (2): 461–9. doi:10.1042/BJ20070940. PMID 17916063.
  • Yeh ET, Gong L, Kamitani T (May 2000). "Ubiquitin-like proteins: new wines in new bottles". Gene. 248 (1–2): 1–14. doi:10.1016/S0378-1119(00)00139-6. PMID 10806345.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Kim KI, Baek SH, Jeon YJ, Nishimori S, Suzuki T, Uchida S, Shimbara N, Saitoh H, Tanaka K, Chung CH (May 2000). "A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs". The Journal of Biological Chemistry. 275 (19): 14102–6. doi:10.1074/jbc.275.19.14102. PMID 10799485.
  • Goodson ML, Hong Y, Rogers R, Matunis MJ, Park-Sarge OK, Sarge KD (May 2001). "Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor". The Journal of Biological Chemistry. 276 (21): 18513–8. doi:10.1074/jbc.M008066200. PMID 11278381.
  • Tojo M, Matsuzaki K, Minami T, Honda Y, Yasuda H, Chiba T, Saya H, Fujii-Kuriyama Y, Nakao M (November 2002). "The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system". The Journal of Biological Chemistry. 277 (48): 46576–85. doi:10.1074/jbc.M205987200. PMID 12354770.
  • Bailey D, O'Hare P (January 2004). "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1". The Journal of Biological Chemistry. 279 (1): 692–703. doi:10.1074/jbc.M306195200. PMID 14563852.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Choi SJ, Chung SS, Rho EJ, Lee HW, Lee MH, Choi HS, Seol JH, Baek SH, Bang OS, Chung CH (October 2006). "Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1". The Journal of Biological Chemistry. 281 (41): 30669–77. doi:10.1074/jbc.M604033200. PMID 16912044.
  • Mukhopadhyay D, Ayaydin F, Kolli N, Tan SH, Anan T, Kametaka A, Azuma Y, Wilkinson KD, Dasso M (September 2006). "SUSP1 antagonizes formation of highly SUMO2/3-conjugated species" (PDF). The Journal of Cell Biology. 174 (7): 939–49. doi:10.1083/jcb.200510103. PMC 2064386. PMID 17000875.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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