SENP2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Sentrin-specific protease 2''' is an [[enzyme]] that in humans is encoded by the ''SENP2'' [[gene]].<ref name="pmid11896061">{{cite journal | vauthors = Hang J, Dasso M | title = Association of the human SUMO-1 protease SENP2 with the nuclear pore | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 19961–6  | date = May 2002 | pmid = 11896061 | pmc =  | doi = 10.1074/jbc.M201799200 }}</ref><ref name="pmid11489887">{{cite journal | vauthors = Nishida T, Kaneko F, Kitagawa M, Yasuda H | title = Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation | journal = J. Biol. Chem. | volume = 276 | issue = 42 | pages = 39060–6  | date = October 2001 | pmid = 11489887 | pmc =  | doi = 10.1074/jbc.M103955200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SENP2 SUMO1/sentrin/SMT3 specific peptidase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59343| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SENP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1tgz.
| PDB = {{PDB2|1tgz}}, {{PDB2|1th0}}, {{PDB2|2io0}}, {{PDB2|2io1}}, {{PDB2|2io2}}, {{PDB2|2io3}}
| Name = SUMO1/sentrin/SMT3 specific peptidase 2
| HGNCid = 23116
| Symbol = SENP2
| AltSymbols =; AXAM2; DKFZp762A2316; KIAA1331; SMT3IP2
| OMIM = 608261
| ECnumber = 
| Homologene = 11005
| MGIid = 1923076
| GeneAtlas_image1 = PBB_GE_SENP2_218122_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008234 |text = cysteine-type peptidase activity}} {{GNF_GO|id=GO:0016929 |text = SUMO-specific protease activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005643 |text = nuclear pore}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0016926 |text = protein desumoylation}} {{GNF_GO|id=GO:0030111 |text = regulation of Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 59343
    | Hs_Ensembl = ENSG00000163904
    | Hs_RefseqProtein = NP_067640
    | Hs_RefseqmRNA = NM_021627
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 186786725
    | Hs_GenLoc_end = 186831577
    | Hs_Uniprot = Q9HC62
    | Mm_EntrezGene = 75826
    | Mm_Ensembl = ENSMUSG00000022855
    | Mm_RefseqmRNA = NM_029457
    | Mm_RefseqProtein = NP_083733
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 21924664
    | Mm_GenLoc_end = 21963134
    | Mm_Uniprot = Q91ZX6
  }}
}}
'''SUMO1/sentrin/SMT3 specific peptidase 2''', also known as '''SENP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SENP2 SUMO1/sentrin/SMT3 specific peptidase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59343| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM]<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SENP2 SUMO1/sentrin/SMT3 specific peptidase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59343| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SENP2 has been shown to [[Protein-protein interaction|interact]] with [[NUP153]].<ref name=pmid11896061 /><ref name=pmid12192048>{{cite journal | vauthors = Zhang H, Saitoh H, Matunis MJ | title = Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex | journal = Mol. Cell. Biol. | volume = 22 | issue = 18 | pages = 6498–508  | date = September 2002 | pmid = 12192048 | pmc = 135644 | doi = 10.1128/MCB.22.18.6498-6508.2002 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS | title = Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs | journal = J. Biol. Chem. | volume = 282 | issue = 36 | pages = 26217–24 | year = 2007 | pmid = 17591783 | doi = 10.1074/jbc.M702444200 }}
| citations =
* {{cite journal | vauthors = Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS | title = Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family | journal = Biochem. J. | volume = 409 | issue = 2 | pages = 461–9 | year = 2008 | pmid = 17916063 | doi = 10.1042/BJ20070940 }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65-73 |year= 2000 |pmid= 10718198 |doi= }}
* {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 1 | pages = 65–73 | year = 2000 | pmid = 10718198 | doi = 10.1093/dnares/7.1.65 }}
*{{cite journal | author=Nishida T, Kaneko F, Kitagawa M, Yasuda H |title=Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39060-6 |year= 2001 |pmid= 11489887 |doi= 10.1074/jbc.M103955200 }}
* {{cite journal | vauthors = Kadoya T, Yamamoto H, Suzuki T, Yukita A, Fukui A, Michiue T, Asahara T, Tanaka K, Asashima M, Kikuchi A | title = Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin | journal = Mol. Cell. Biol. | volume = 22 | issue = 11 | pages = 3803–19 | year = 2002 | pmid = 11997515 | pmc = 133821 | doi = 10.1128/MCB.22.11.3803-3819.2002 }}
*{{cite journal | author=Hang J, Dasso M |title=Association of the human SUMO-1 protease SENP2 with the nuclear pore. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19961-6 |year= 2002 |pmid= 11896061 |doi= 10.1074/jbc.M201799200 }}
* {{cite journal | vauthors = Zhang H, Saitoh H, Matunis MJ | title = Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex | journal = Mol. Cell. Biol. | volume = 22 | issue = 18 | pages = 6498–508 | year = 2002 | pmid = 12192048 | pmc = 135644 | doi = 10.1128/MCB.22.18.6498-6508.2002 }}
*{{cite journal | author=Kadoya T, Yamamoto H, Suzuki T, ''et al.'' |title=Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3803-19 |year= 2002 |pmid= 11997515 |doi= }}
* {{cite journal | vauthors = Best JL, Ganiatsas S, Agarwal S, Changou A, Salomoni P, Shirihai O, Meluh PB, Pandolfi PP, Zon LI | title = SUMO-1 protease-1 regulates gene transcription through PML | journal = Mol. Cell | volume = 10 | issue = 4 | pages = 843–55 | year = 2002 | pmid = 12419228 | doi = 10.1016/S1097-2765(02)00699-8 }}
*{{cite journal | author=Zhang H, Saitoh H, Matunis MJ |title=Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. |journal=Mol. Cell. Biol. |volume=22 |issue= 18 |pages= 6498-508 |year= 2002 |pmid= 12192048 |doi= }}
* {{cite journal | vauthors = Reverter D, Lima CD | title = A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex | journal = Structure | volume = 12 | issue = 8 | pages = 1519–31 | year = 2004 | pmid = 15296745 | doi = 10.1016/j.str.2004.05.023 }}
*{{cite journal | author=Best JL, Ganiatsas S, Agarwal S, ''et al.'' |title=SUMO-1 protease-1 regulates gene transcription through PML. |journal=Mol. Cell |volume=10 |issue= 4 |pages= 843-55 |year= 2002 |pmid= 12419228 |doi=  }}
* {{cite journal | vauthors = Itahana Y, Yeh ET, Zhang Y | title = Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2 | journal = Mol. Cell. Biol. | volume = 26 | issue = 12 | pages = 4675–89 | year = 2006 | pmid = 16738331 | pmc = 1489137 | doi = 10.1128/MCB.01830-05 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Reverter D, Lima CD | title = Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates | journal = Nat. Struct. Mol. Biol. | volume = 13 | issue = 12 | pages = 1060–8 | year = 2006 | pmid = 17099700 | doi = 10.1038/nsmb1168 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Reverter D, Lima CD |title=A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. |journal=Structure |volume=12 |issue= 8 |pages= 1519-31 |year= 2005 |pmid= 15296745 |doi= 10.1016/j.str.2004.05.023 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Itahana Y, Yeh ET, Zhang Y |title=Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2. |journal=Mol. Cell. Biol. |volume=26 |issue= 12 |pages= 4675-89 |year= 2006 |pmid= 16738331 |doi= 10.1128/MCB.01830-05 }}
*{{cite journal | author=Reverter D, Lima CD |title=Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 12 |pages= 1060-8 |year= 2007 |pmid= 17099700 |doi= 10.1038/nsmb1168 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:06, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sentrin-specific protease 2 is an enzyme that in humans is encoded by the SENP2 gene.[1][2][3]

Function

SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM][3]

Interactions

SENP2 has been shown to interact with NUP153.[1][4]

References

  1. ↑ 1.0 1.1 Hang J, Dasso M (May 2002). "Association of the human SUMO-1 protease SENP2 with the nuclear pore". J. Biol. Chem. 277 (22): 19961–6. doi:10.1074/jbc.M201799200. PMID 11896061.
  2. ↑ Nishida T, Kaneko F, Kitagawa M, Yasuda H (October 2001). "Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation". J. Biol. Chem. 276 (42): 39060–6. doi:10.1074/jbc.M103955200. PMID 11489887.
  3. ↑ 3.0 3.1 "Entrez Gene: SENP2 SUMO1/sentrin/SMT3 specific peptidase 2".
  4. ↑ Zhang H, Saitoh H, Matunis MJ (September 2002). "Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex". Mol. Cell. Biol. 22 (18): 6498–508. doi:10.1128/MCB.22.18.6498-6508.2002. PMC 135644. PMID 12192048.

Further reading


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