View source for SCN3B

{{Infobox_gene}}
'''Sodium channel subunit beta-3''' is a [[protein]] that in humans is encoded by the ''SCN3B'' [[gene]].<ref name="pmid10688874">{{cite journal | vauthors = Morgan K, Stevens EB, Shah B, Cox PJ, Dixon AK, Lee K, Pinnock RD, Hughes J, Richardson PJ, Mizuguchi K, Jackson AP | title = β3: An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics | journal = Proc Natl Acad Sci U S A | volume = 97 | issue = 5 | pages = 2308–13 |date=Apr 2000 | pmid = 10688874 | pmc = 15797 | doi = 10.1073/pnas.030362197 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SCN3B sodium channel, voltage-gated, type III, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55800| accessdate = }}</ref> Two alternatively spliced variants, encoding the same protein, have been identified.

== Function ==

Voltage-gated sodium channels are transmembrane [[glycoprotein]] complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of [[action potential]]s in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel.<ref name="entrez" />

== Clinical significance ==

Mutations in the gene are associated with abnormal cardiac electrophysiology.<ref name="pmid19351516">{{cite journal | vauthors = Hakim P, Gurung IS, Pedersen TH, Thresher R, Brice N, Lawrence J, Grace AA, Huang CL | title = Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties | journal = Prog. Biophys. Mol. Biol. | volume = 98 | issue = 2-3 | pages = 251–66 | year = 2008 | pmid = 19351516 | pmc = 2764399 | doi = 10.1016/j.pbiomolbio.2009.01.005  }}</ref><ref name="pmid19796257">{{cite journal | vauthors = Hakim P, Brice N, Thresher R, Lawrence J, Zhang Y, Jackson AP, Grace AA, Huang CL | title = Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties | journal = Acta Physiol (Oxf) | volume = 198 | issue = 1 | pages = 47–59 |date=January 2010 | pmid = 19796257 | doi = 10.1111/j.1748-1716.2009.02048.x | pmc = 3763209 }}</ref>

==See also==
* [[Sodium channel]]

==References==
{{reflist}}
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==Further reading==
{{refbegin | 2}}
*{{cite journal   |vauthors=Hirosawa M, Nagase T, Ishikawa K, etal |title=Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain |journal=DNA Res. |volume=6 |issue= 5 |pages= 329–36 |year= 2000 |pmid= 10574461 |doi=10.1093/dnares/6.5.329  }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal   |vauthors=Stevens EB, Cox PJ, Shah BS, etal |title=Tissue distribution and functional expression of the human voltage-gated sodium channel beta3 subunit |journal=Pflügers Arch. |volume=441 |issue= 4 |pages= 481–8 |year= 2001 |pmid= 11212211 |doi=10.1007/s004240000449  }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732 }}
*{{cite journal  | vauthors=Ratcliffe CF, Westenbroek RE, Curtis R, Catterall WA |title=Sodium channel β1 and β3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain |journal=J. Cell Biol. |volume=154 |issue= 2 |pages= 427–34 |year= 2001 |pmid= 11470829 |doi=10.1083/jcb.200102086  | pmc=2150779  }}
*{{cite journal   |vauthors=Meadows LS, Chen YH, Powell AJ, etal |title=Functional modulation of human brain Nav1.3 sodium channels, expressed in mammalian cells, by auxiliary beta 1, beta 2 and beta 3 subunits |journal=Neuroscience |volume=114 |issue= 3 |pages= 745–53 |year= 2002 |pmid= 12220575 |doi=10.1016/S0306-4522(02)00242-7  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Casula MA, Facer P, Powell AJ, etal |title=Expression of the sodium channel beta3 subunit in injured human sensory neurons |journal=NeuroReport |volume=15 |issue= 10 |pages= 1629–32 |year= 2004 |pmid= 15232296 |doi=10.1097/01.wnr.0000134927.02776.ae  }}
*{{cite journal   |vauthors=Adachi K, Toyota M, Sasaki Y, etal |title=Identification of SCN3B as a novel p53-inducible proapoptotic gene |journal=Oncogene |volume=23 |issue= 47 |pages= 7791–8 |year= 2004 |pmid= 15334053 |doi= 10.1038/sj.onc.1208067 }}
*{{cite journal   |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501 }}
*{{cite journal   |vauthors=Hakim P, Gurung IS, Pedersen TH, etal |title=Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties |journal=Prog Biophys Mol Biol. |volume=98 |issue= 2–3 |pages= 251–66 |year= 2008 |pmid= 19351516 |doi= 10.1016/j.pbiomolbio.2009.01.005  | pmc=2764399 }}
{{refend}}

==External links==
* [https://www.ncbi.nlm.nih.gov/books/NBK1517/  GeneReviews/NIH/NCBI/UW entry on Brugada syndrome]
* {{MeshName|SCNB3+protein,+human}}

{{NLM content}}
{{Ion channels|g2}}

[[Category:Sodium channels]]


{{membrane-protein-stub}}