SCAND1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''SCAN domain-containing protein 1''' is a [[protein]] that in humans is encoded by the ''SCAND1'' [[gene]].<ref name="pmid10777584">{{cite journal | vauthors = Sander TL, Haas AL, Peterson MJ, Morris JF | title = Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations | journal = The Journal of Biological Chemistry | volume = 275 | issue = 17 | pages = 12857–67 | date = Apr 2000 | pmid = 10777584 | pmc =  | doi = 10.1074/jbc.275.17.12857 }}</ref><ref name="pmid10747874">{{cite journal | vauthors = Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S | title = The SCAN domain mediates selective oligomerization | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 17173–9 | date = Jun 2000 | pmid = 10747874 | pmc =  | doi = 10.1074/jbc.M000119200 }}</ref><ref name="pmid12444922">{{cite journal | vauthors = Babb R, Bowen BR | title = SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain | journal = The Biochemical Journal | volume = 370 | issue = Pt 2 | pages = 719–27 | date = Mar 2003 | pmid = 12444922 | pmc = 1223195 | doi = 10.1042/BJ20021378 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SCAND1 SCAN domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51282| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SCAN domain containing 1
| HGNCid = 10566
| Symbol = SCAND1
| AltSymbols =; RAZ1; SDP1
| OMIM = 610416
| ECnumber = 
| Homologene = 10642
| MGIid = 1343132
| GeneAtlas_image1 = PBB_GE_SCAND1_218206_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51282
    | Hs_Ensembl = ENSG00000171222
    | Hs_RefseqProtein = NP_057642
    | Hs_RefseqmRNA = NM_016558
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 34004960
    | Hs_GenLoc_end = 34005842
    | Hs_Uniprot = P57086
    | Mm_EntrezGene = 19018
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_020255
    | Mm_RefseqProtein = NP_064651
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''SCAN domain containing 1''', also known as '''SCAND1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SCAND1 SCAN domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51282| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 amino acids originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. Functional studies have established that the SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, and maybe involved in regulation of transcriptional activity. Two transcript variants with different 5' UTRs, but encoding the same protein, have been described for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. Functional studies have established that the SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, and maybe involved in regulation of transcriptional activity. Two transcript variants with different 5' UTRs, but encoding the same protein, have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SCAND1 SCAN domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51282| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SCAND1 has been shown to [[Protein-protein interaction|interact]] with [[MZF1]].<ref name=pmid10777584 />
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Williams AJ, Blacklow SC, Collins T | title = The zinc finger-associated SCAN box is a conserved oligomerization domain | journal = Molecular and Cellular Biology | volume = 19 | issue = 12 | pages = 8526–35 | date = Dec 1999 | pmid = 10567577 | pmc = 84969 | doi =  }}
| citations =
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Williams AJ, Blacklow SC, Collins T |title=The zinc finger-associated SCAN box is a conserved oligomerization domain. |journal=Mol. Cell. Biol. |volume=19 |issue= 12 |pages= 8526-35 |year= 2000 |pmid= 10567577 |doi=  }}
* {{cite journal | vauthors = Sander TL, Morris JF | title = Characterization of the SCAN box encoding RAZ1 gene: analysis of cDNA transcripts, expression, and cellular localization | journal = Gene | volume = 296 | issue = 1-2 | pages = 53–64 | date = Aug 2002 | pmid = 12383503 | doi = 10.1016/S0378-1119(02)00792-8 }}
*{{cite journal  | author=Schumacher C, Wang H, Honer C, ''et al.'' |title=The SCAN domain mediates selective oligomerization. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 17173-9 |year= 2000 |pmid= 10747874 |doi= 10.1074/jbc.M000119200 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal  | author=Sander TL, Haas AL, Peterson MJ, Morris JF |title=Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations. |journal=J. Biol. Chem. |volume=275 |issue= 17 |pages= 12857-67 |year= 2000 |pmid= 10777584 |doi=  }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415–8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
* {{cite journal | vauthors = Carneiro FR, Silva TC, Alves AC, Haline-Vaz T, Gozzo FC, Zanchin NI | title = Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1 | journal = Biochemical and Biophysical Research Communications | volume = 343 | issue = 1 | pages = 260–8 | date = Apr 2006 | pmid = 16540086 | doi = 10.1016/j.bbrc.2006.02.140 }}
*{{cite journal | author=Sander TL, Morris JF |title=Characterization of the SCAN box encoding RAZ1 gene: analysis of cDNA transcripts, expression, and cellular localization. |journal=Gene |volume=296 |issue= 1-2 |pages= 53-64 |year= 2003 |pmid= 12383503 |doi=  }}
*{{cite journal  | author=Babb R, Bowen BR |title=SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain. |journal=Biochem. J. |volume=370 |issue= Pt 2 |pages= 719-27 |year= 2003 |pmid= 12444922 |doi= 10.1042/BJ20021378 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Carneiro FR, Silva TC, Alves AC, ''et al.'' |title=Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1. |journal=Biochem. Biophys. Res. Commun. |volume=343 |issue= 1 |pages= 260-8 |year= 2006 |pmid= 16540086 |doi= 10.1016/j.bbrc.2006.02.140 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-20-stub}}

Latest revision as of 05:58, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SCAN domain-containing protein 1 is a protein that in humans is encoded by the SCAND1 gene.[1][2][3][4]

Function

The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 amino acids originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. Functional studies have established that the SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, and maybe involved in regulation of transcriptional activity. Two transcript variants with different 5' UTRs, but encoding the same protein, have been described for this gene.[4]

Interactions

SCAND1 has been shown to interact with MZF1.[1]

References

  1. ↑ 1.0 1.1 Sander TL, Haas AL, Peterson MJ, Morris JF (Apr 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". The Journal of Biological Chemistry. 275 (17): 12857–67. doi:10.1074/jbc.275.17.12857. PMID 10777584.
  2. ↑ Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry. 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.
  3. ↑ Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal. 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
  4. ↑ 4.0 4.1 "Entrez Gene: SCAND1 SCAN domain containing 1".

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=SCAND1&oldid=1419575"