SAT1 (gene)

Spermidine/spermine N1-acetyltransferase 1
File:PBB Protein SAT1 image.jpg PDB rendering based on 2b3u.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2b3u​, 2b3v​, 2b4b​, 2b4d​, 2b58​, 2b5g​, 2f5i​, 2fxf​, 2g3t​, 2jev​
Identifiers
Symbols	SAT1 ; DC21; KFSD; SAT; SSAT; SSAT-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37716
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO
RNA expression pattern
File:PBB GE SAT1 203455 s at tn.png
File:PBB GE SAT1 210592 s at tn.png
File:PBB GE SAT1 213988 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Spermidine/spermine N1-acetyltransferase 1, also known as SAT1, is a human gene.

Spermidine/spermine N(1)-acetyltransferase (SPD/SPM acetyltransferase) is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the N(1)-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase, spermine can be converted to spermidine and spermidine to putrescine.[supplied by OMIM]

Further reading

• Lake JA, Carr J, Feng F; et al. (2003). "The role of Vif during HIV-1 infection: interaction with novel host cellular factors". J. Clin. Virol. 26 (2): 143–52. PMID 12600646.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiao L, Celano P, Mank AR; et al. (1992). "Structure of the human spermidine/spermine N1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1)". Biochem. Biophys. Res. Commun. 187 (3): 1493–502. PMID 1417826.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiao L, Celano P, Mank AR; et al. (1991). "Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase". Biochem. Biophys. Res. Commun. 179 (1): 407–15. PMID 1652956.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Casero RA, Celano P, Ervin SJ; et al. (1991). "Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase". J. Biol. Chem. 266 (2): 810–4. PMID 1985966.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Libby PR, Ganis B, Bergeron RJ, Porter CW (1991). "Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells". Arch. Biochem. Biophys. 284 (2): 238–44. PMID 1989509.CS1 maint: Multiple names: authors list (link)
• Casero RA, Celano P, Ervin SJ; et al. (1990). "High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma". Biochem. J. 270 (3): 615–20. PMID 2241897.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Casero RA, Gabrielson EW, Pegg AE (1994). "Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues". Cancer Res. 54 (15): 3955–8. PMID 8033120.CS1 maint: Multiple names: authors list (link)
• Xiao L, Casero RA (1996). "Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells". Biochem. J. 313 ( Pt 2): 691–6. PMID 8573111.
• Coleman CS, Huang H, Pegg AE (1996). "Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase". Biochem. J. 316 ( Pt 3): 697–701. PMID 8670140.CS1 maint: Multiple names: authors list (link)
• Bordin L, Vargiu C, Colombatto S; et al. (1997). "Casein kinase 2 phosphorylates recombinant human spermidine/spermine N1-acetyltransferase on both serine and threonine residues". Biochem. Biophys. Res. Commun. 229 (3): 845–51. doi:10.1006/bbrc.1996.1890. PMID 8954982.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bettuzzi S, Davalli P, Astancolle S; et al. (2000). "Tumor progression is accompanied by significant changes in the levels of expression of polyamine metabolism regulatory genes and clusterin (sulfated glycoprotein 2) in human prostate cancer specimens". Cancer Res. 60 (1): 28–34. PMID 10646846.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coleman CS, Pegg AE (2001). "Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation". Biochem. J. 358 (Pt 1): 137–45. PMID 11485561.
• Bordin L, Vargiu C, Clari G; et al. (2002). "Phosphorylation of recombinant human spermidine/spermine N(1)-acetyltransferase by CK1 and modulation of its binding to mitochondria: a comparison with CK2". Biochem. Biophys. Res. Commun. 290 (1): 463–8. doi:10.1006/bbrc.2001.6204. PMID 11779193.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nikiforova NN, Velikodvorskaja TV, Kachko AV; et al. (2002). "Induction of alternatively spliced spermidine/spermine N1-acetyltransferase mRNA in the human kidney cells infected by venezuelan equine encephalitis and tick-borne encephalitis viruses". Virology. 297 (2): 163–71. PMID 12083816.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gimelli G, Giglio S, Zuffardi O; et al. (2002). "Gene dosage of the spermidine/spermine N(1)-acetyltransferase ( SSAT) gene with putrescine accumulation in a patient with a Xp21.1p22.12 duplication and keratosis follicularis spinulosa decalvans (KFSD)". Hum. Genet. 111 (3): 235–41. doi:10.1007/s00439-002-0791-6. PMID 12215835.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomitori H, Nenoi M, Mita K; et al. (2003). "Functional characterization of the human spermidine/spermine N(1)-acetyltransferase gene promoter". Biochim. Biophys. Acta. 1579 (2–3): 180–4. PMID 12427553.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Izmailova E, Bertley FM, Huang Q; et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)