SAE1

SUMO1 activating enzyme subunit 1
File:PBB Protein SAE1 image.jpg PDB rendering based on 1y8q.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1y8q​, 1y8r​
Identifiers
Symbols	SAE1 ; AOS1; FLJ3091; HSPC140; SUA1
External IDs	Template:MGI HomoloGene: 4019
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE SAE1 217946 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SUMO1 activating enzyme subunit 1, also known as SAE1, is a human gene.

Further reading

• Okuma T, Honda R, Ichikawa G; et al. (1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2". Biochem. Biophys. Res. Commun. 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID 9920803.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Desterro JM, Rodriguez MS, Kemp GD, Hay RT (1999). "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1". J. Biol. Chem. 274 (15): 10618–24. PMID 10187858.CS1 maint: Multiple names: authors list (link)
• Gong L, Li B, Millas S, Yeh ET (1999). "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex". FEBS Lett. 448 (1): 185–9. PMID 10217437.CS1 maint: Multiple names: authors list (link)
• Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. PMID 11042152.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tatham MH, Jaffray E, Vaughan OA; et al. (2001). "Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9". J. Biol. Chem. 276 (38): 35368–74. doi:10.1074/jbc.M104214200. PMID 11451954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Azuma Y, Tan SH, Cavenagh MM; et al. (2001). "Expression and regulation of the mammalian SUMO-1 E1 enzyme". FASEB J. 15 (10): 1825–7. PMID 11481243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tatham MH, Kim S, Yu B; et al. (2003). "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation". Biochemistry. 42 (33): 9959–69. doi:10.1021/bi0345283. PMID 12924945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Komatsu T, Mizusaki H, Mukai T; et al. (2005). "Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9". Mol. Endocrinol. 18 (10): 2451–62. doi:10.1210/me.2004-0173. PMID 15192080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Salinas S, Briançon-Marjollet A, Bossis G; et al. (2004). "SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1". J. Cell Biol. 165 (6): 767–73. doi:10.1083/jcb.200310136. PMID 15210726.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin JY, Ohshima T, Shimotohno K (2004). "Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53". FEBS Lett. 573 (1–3): 15–8. doi:10.1016/j.febslet.2004.07.059. PMID 15327968.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boggio R, Colombo R, Hay RT; et al. (2005). "A mechanism for inhibiting the SUMO pathway". Mol. Cell. 16 (4): 549–61. doi:10.1016/j.molcel.2004.11.007. PMID 15546615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lois LM, Lima CD (2005). "Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1". EMBO J. 24 (3): 439–51. doi:10.1038/sj.emboj.7600552. PMID 15660128.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Klenk C, Humrich J, Quitterer U, Lohse MJ (2006). "SUMO-1 controls the protein stability and the biological function of phosducin". J. Biol. Chem. 281 (13): 8357–64. doi:10.1074/jbc.M513703200. PMID 16421094.CS1 maint: Multiple names: authors list (link)
• Li T, Santockyte R, Shen RF; et al. (2006). "A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers". Arch. Biochem. Biophys. 453 (1): 70–4. doi:10.1016/j.abb.2006.03.002. PMID 16620772.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pan X, Li H, Zhang P; et al. (2006). "Ubc9 interacts with SOX4 and represses its transcriptional activity". Biochem. Biophys. Res. Commun. 344 (3): 727–34. doi:10.1016/j.bbrc.2006.03.194. PMID 16631117.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)