S100A9

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S100 calcium binding protein A9
File:PBB Protein S100A9 image.jpg
PDB rendering based on 1irj.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols S100A9 ; MIF; 60B8AG; CFAG; NIF; CAGB; CGLB; L1AG; LIAG; MAC387; MRP14; P14
External IDs Template:OMIM5 Template:MGI HomoloGene: 2227
RNA expression pattern
File:PBB GE S100A9 203535 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

S100 calcium binding protein A9, also known as S100A9, is a human gene.[1]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: S100A9 S100 calcium binding protein A9".

Further reading

  • Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends Biochem. Sci. 21 (4): 134–40. PMID 8701470.
  • Kerkhoff C, Klempt M, Sorg C (1999). "Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)". Biochim. Biophys. Acta. 1448 (2): 200–11. PMID 9920411.
  • Nacken W, Roth J, Sorg C, Kerkhoff C (2003). "S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity". Microsc. Res. Tech. 60 (6): 569–80. doi:10.1002/jemt.10299. PMID 12645005.
  • Rasmussen HH, van Damme J, Puype M; et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. PMID 1286667.
  • Longbottom D, Sallenave JM, van Heyningen V (1992). "Subunit structure of calgranulins A and B obtained from sputum, plasma, granulocytes and cultured epithelial cells". Biochim. Biophys. Acta. 1120 (2): 215–22. PMID 1562590.
  • Dorin JR, Emslie E, van Heyningen V (1991). "Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3". Genomics. 8 (3): 420–6. PMID 2149559.
  • Edgeworth J, Freemont P, Hogg N (1989). "Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14". Nature. 342 (6246): 189–92. doi:10.1038/342189a0. PMID 2478889.
  • Murao S, Collart FR, Huberman E (1989). "A protein containing the cystic fibrosis antigen is an inhibitor of protein kinases". J. Biol. Chem. 264 (14): 8356–60. PMID 2656677.
  • Odink K, Cerletti N, Brüggen J; et al. (1987). "Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis". Nature. 330 (6143): 80–2. doi:10.1038/330080a0. PMID 3313057.
  • Lagasse E, Clerc RG (1988). "Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation". Mol. Cell. Biol. 8 (6): 2402–10. PMID 3405210.
  • Schäfer BW, Wicki R, Engelkamp D; et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. PMID 7759097.
  • Engelkamp D, Schäfer BW, Mattei MG; et al. (1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6547–51. PMID 8341667.
  • Roth J, Burwinkel F, van den Bos C; et al. (1993). "MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner". Blood. 82 (6): 1875–83. PMID 8400238.
  • Miyasaki KT, Bodeau AL, Murthy AR, Lehrer RI (1993). "In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena". J. Dent. Res. 72 (2): 517–23. PMID 8423249.
  • Newton RA, Hogg N (1998). "The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils". J. Immunol. 160 (3): 1427–35. PMID 9570563.
  • Vogl T, Pröpper C, Hartmann M; et al. (1999). "S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14". J. Biol. Chem. 274 (36): 25291–6. PMID 10464253.
  • Kerkhoff C, Klempt M, Kaever V, Sorg C (2000). "The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophils". J. Biol. Chem. 274 (46): 32672–9. PMID 10551823.
  • Stulík J, Koupilova K, Osterreicher J; et al. (2000). "Protein abundance alterations in matched sets of macroscopically normal colon mucosa and colorectal carcinoma". Electrophoresis. 20 (18): 3638–46. doi:10.1002/(SICI)1522-2683(19991201)20:18<3638::AID-ELPS3638>3.0.CO;2-W. PMID 10612291.

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