Roseola overview: Difference between revisions
| Line 14: | Line 14: | ||
== Pathophysiology == | == Pathophysiology == | ||
Primary infection with HHV-6 has been shown to be the cause of exanthem subitum (roseola) in infants and can also result in an infectious mononucleosis-like illness in adults. | |||
== Causes == | == Causes == | ||
Revision as of 19:44, 30 May 2017
|
Roseola Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Roseola overview On the Web |
|
American Roentgen Ray Society Images of Roseola overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]
Overview
Roseola is a disease of infants. It is characterized by an abrupt rise in body temperature to as high as 40°C (104°F) followed by a rapid drop to normal within the next 2–4 days which coincides with the appearance of an erythematous maculopapular skin rash that persists for 1–3 days. It is typically a beningn disease which resolves without sequalae. Roseola disease is caused by Human herpes virus 6 (HHV6). HHV-6 is a member of the Herpesvirales order, Herpesviridae family, Betaherpesvirinae subfamily, and Roseolovirus genus. HHV-6A and HHV-6B are two distinct species of HHV-6.
Historical perspective
Human herpes virus 6 was first identified in 1986. Herpesviruses have a unique four-layered structure: a core containing the large, double-stranded DNA genome is enclosed by an icosapentahedral capsid which is composed of capsomers. The capsid is surrounded by an amorphous protein coat called the tegument. It is encased in a glycoprotein-bearing lipid bilayer envelope.
Classification
There is no established classification system for roseola.
Pathophysiology
Primary infection with HHV-6 has been shown to be the cause of exanthem subitum (roseola) in infants and can also result in an infectious mononucleosis-like illness in adults.