Racecadotril: Difference between revisions
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{{Drugbox | {{Drugbox | ||
| IUPAC_name = benzyl {[3-(acetylsulfanyl)-2-benzylpropanoyl]amino}acetate | | IUPAC_name = benzyl {[3-(acetylsulfanyl)-2-benzylpropanoyl]amino}acetate | ||
| image = Racecadotril. | | image = Racecadotril Wiki Str.png | ||
| CAS_number = 81110-73-8 | | CAS_number = 81110-73-8 | ||
| ATC_prefix = A07 | | ATC_prefix = A07 | ||
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| routes_of_administration = Oral | | routes_of_administration = Oral | ||
}} | }} | ||
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==Overview== | |||
'''Racecadotril''' is an [[antidiarrheal]] drug which acts as a peripherally acting enkephalinase inhibitor.<ref>Matheson AJ, Noble S. Racecadotril. ''Drugs''. 2000 Apr;59(4):829-35. [http://www.ncbi.nlm.nih.gov/pubmed/10804038 PMID 10804038]</ref> Unlike other medications used to treat diarrhea, which [[Antipropulsive|reduce intestinal motility]], racecadotril has an [[wikt:antisecretory|antisecretory]] effect—it reduces the secretion of water and [[electrolytes]] into the intestine.<ref>(2001) "Racecadotril: an Antidiarrhoeal Suitable for Use in Infants and Young Children". ''Drug Ther Perspect'' '''17''' (8): 1–5. [http://www.medscape.com/viewarticle/406488 Free full text with registration] at [[Medscape]]</ref> It is available in France (where it was first introduced in 1993 and is widely used) and other European countries, as well as most of South America and some [[South East Asia]]n countries, but not in the United States. It is sold under the tradename Hidrasec. | '''Racecadotril''' is an [[antidiarrheal]] drug which acts as a peripherally acting enkephalinase inhibitor.<ref>Matheson AJ, Noble S. Racecadotril. ''Drugs''. 2000 Apr;59(4):829-35. [http://www.ncbi.nlm.nih.gov/pubmed/10804038 PMID 10804038]</ref> Unlike other medications used to treat diarrhea, which [[Antipropulsive|reduce intestinal motility]], racecadotril has an [[wikt:antisecretory|antisecretory]] effect—it reduces the secretion of water and [[electrolytes]] into the intestine.<ref>(2001) "Racecadotril: an Antidiarrhoeal Suitable for Use in Infants and Young Children". ''Drug Ther Perspect'' '''17''' (8): 1–5. [http://www.medscape.com/viewarticle/406488 Free full text with registration] at [[Medscape]]</ref> It is available in France (where it was first introduced in 1993 and is widely used) and other European countries, as well as most of South America and some [[South East Asia]]n countries, but not in the United States. It is sold under the tradename Hidrasec. | ||
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==References== | ==References== | ||
{{Reflist}} | {{Reflist|2}} | ||
==See Also== | ==See Also== | ||
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{{Antidiarrheals, intestinal anti-inflammatory/anti-infective agents}} | {{Antidiarrheals, intestinal anti-inflammatory/anti-infective agents}} | ||
[[Category:Drug]] | |||
[[Category:Enkephalinase inhibitors]] | [[Category:Enkephalinase inhibitors]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WS}} | {{WS}} | ||
Revision as of 12:51, 8 April 2015
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| Routes of administration | Oral |
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| PubChem CID | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C21H23NO4S |
| Molar mass | 385.47662 g/mol |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Racecadotril is an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor.[1] Unlike other medications used to treat diarrhea, which reduce intestinal motility, racecadotril has an antisecretory effect—it reduces the secretion of water and electrolytes into the intestine.[2] It is available in France (where it was first introduced in 1993 and is widely used) and other European countries, as well as most of South America and some South East Asian countries, but not in the United States. It is sold under the tradename Hidrasec.
A small randomized controlled trial found racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy.[3]
References
- ↑ Matheson AJ, Noble S. Racecadotril. Drugs. 2000 Apr;59(4):829-35. PMID 10804038
- ↑ (2001) "Racecadotril: an Antidiarrhoeal Suitable for Use in Infants and Young Children". Drug Ther Perspect 17 (8): 1–5. Free full text with registration at Medscape
- ↑ Salazar-Lindo E, Santisteban-Ponce J, Chea-Woo E, Gutierrez M (2000). "Racecadotril in the treatment of acute watery diarrhea in children". N. Engl. J. Med. 343 (7): 463–7. PMID 10944563.
See Also
Template:Antidiarrheals, intestinal anti-inflammatory/anti-infective agents
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- Enkephalinase inhibitors