RHOJ: Difference between revisions

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{{Infobox_gene}}
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'''Rho-related GTP-binding protein RhoJ''' is a [[protein]] that in humans is encoded by the ''RHOJ'' [[gene]].<ref name="pmid10967094">{{cite journal |vauthors=Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouviere C, Blangy A, Fort P | title = Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42 | journal = J Biol Chem | volume = 275 | issue = 46 | pages = 36457–64 |date=Dec 2000 | pmid = 10967094 | pmc =  | doi = 10.1074/jbc.M003487200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RHOJ ras homolog gene family, member J| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57381| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Ras homolog gene family, member J
| HGNCid = 688
| Symbol = RHOJ
| AltSymbols =; ARHJ; FLJ14445; MGC34777; RASL7B; TC10B; TCL
| OMIM = 607653
| ECnumber = 
| Homologene = 56894
| MGIid = 1931551
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}}{{GNF_GO|id=GO:0003924 |text = GTPase activity}}{{GNF_GO|id=GO:0005515 |text = protein binding}}{{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0007266 |text = Rho protein signal transduction}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57381
    | Hs_Ensembl = ENSG00000126785
    | Hs_RefseqProtein = NP_065714
    | Hs_RefseqmRNA = NM_020663
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 62740898
    | Hs_GenLoc_end = 62828312
    | Hs_Uniprot = Q9H4E5
    | Mm_EntrezGene = 80837
    | Mm_Ensembl = ENSMUSG00000046768
    | Mm_RefseqmRNA = NM_023275
    | Mm_RefseqProtein = NP_075764
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 76227153
    | Mm_GenLoc_end = 76320295
    | Mm_Uniprot = Q3TZU6
  }}
}}
'''Ras homolog gene family, member J''', also known as '''RHOJ''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RHOJ ras homolog gene family, member J| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57381| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = ARHJ belongs to the Rho family of small GTP-binding proteins. Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes, such as cell proliferation and motility and the establishment of cell polarity. They are also involved in pathophysiologic process, such as cell transformation and metastasis.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RHOJ ras homolog gene family, member J| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57381| accessdate = }}</ref>
| summary_text = ARHJ belongs to the Rho family of small GTP-binding proteins. Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes, such as cell proliferation and motility and the establishment of cell polarity. They are also involved in pathophysiologic process, such as cell transformation and metastasis.[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal  | author=Barrios-Rodiles M |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |name-list-format=vanc| author2=Brown KR  | author3=Ozdamar B  | display-authors=3  | last4=Bose  | first4=R  | last5=Liu  | first5=Z  | last6=Donovan  | first6=RS  | last7=Shinjo  | first7=F  | last8=Liu  | first8=Y  | last9=Dembowy  | first9=J }}
*{{cite journal  | author=Nishikimi A, Meller N, Uekawa N, ''et al.'' |title=Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. |journal=FEBS Lett. |volume=579 |issue= 5 |pages= 1039-46 |year= 2005 |pmid= 15710388 |doi= 10.1016/j.febslet.2005.01.006 }}
*{{cite journal  | author=Nishikimi A |title=Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes |journal=FEBS Lett. |volume=579 |issue= 5 |pages= 1039–46 |year= 2005 |pmid= 15710388 |doi= 10.1016/j.febslet.2005.01.006 |name-list-format=vanc| author2=Meller N  | author3=Uekawa N  | display-authors=3  | last4=Isobe  | first4=K  | last5=Schwartz  | first5=M  | last6=Maruyama  | first6=M }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Ruusala A, Aspenström P |title=Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology. |journal=FEBS Lett. |volume=572 |issue= 1-3 |pages= 159-66 |year= 2004 |pmid= 15304341 |doi= 10.1016/j.febslet.2004.06.095 }}
*{{cite journal  |vauthors=Ruusala A, Aspenström P |title=Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology |journal=FEBS Lett. |volume=572 |issue= 1–3 |pages= 159–66 |year= 2004 |pmid= 15304341 |doi= 10.1016/j.febslet.2004.06.095 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=de Toledo M, Senic-Matuglia F, Salamero J, ''et al.'' |title=The GTP/GDP cycling of rho GTPase TCL is an essential regulator of the early endocytic pathway. |journal=Mol. Biol. Cell |volume=14 |issue= 12 |pages= 4846-56 |year= 2004 |pmid= 12960428 |doi= 10.1091/mbc.E03-04-0254 }}
*{{cite journal  | author=de Toledo M |title=The GTP/GDP Cycling of Rho GTPase TCL Is an Essential Regulator of the Early Endocytic Pathway |journal=Mol. Biol. Cell |volume=14 |issue= 12 |pages= 4846–56 |year= 2004 |pmid= 12960428 |doi= 10.1091/mbc.E03-04-0254 | pmc=284789  |name-list-format=vanc| author2=Senic-Matuglia F  | author3=Salamero J  | display-authors=3  | last4=Uze  | first4=G  | last5=Comunale  | first5=F  | last6=Fort  | first6=P  | last7=Blangy  | first7=A }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Vignal E, De Toledo M, Comunale F, ''et al.'' |title=Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42. |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36457-64 |year= 2000 |pmid= 10967094 |doi= 10.1074/jbc.M003487200 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 09:12, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene.[1][2]

ARHJ belongs to the Rho family of small GTP-binding proteins. Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes, such as cell proliferation and motility and the establishment of cell polarity. They are also involved in pathophysiologic process, such as cell transformation and metastasis.[supplied by OMIM][2]

References

  1. ↑ Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouviere C, Blangy A, Fort P (Dec 2000). "Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42". J Biol Chem. 275 (46): 36457–64. doi:10.1074/jbc.M003487200. PMID 10967094.
  2. ↑ 2.0 2.1 "Entrez Gene: RHOJ ras homolog gene family, member J".

Further reading



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