RGS14

Regulator of G-protein signalling 14
File:PBB Protein RGS14 image.jpg PDB rendering based on 1kjy.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1kjy​, 2jnu​
Identifiers
Symbols	RGS14 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4735
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RGS14 38290 at tn.png
File:PBB GE RGS14 204280 at tn.png
File:PBB GE RGS14 211021 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Regulator of G-protein signalling 14, also known as RGS14, is a human gene.

This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Further reading

• Snow BE, Antonio L, Suggs S; et al. (1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14". Biochem. Biophys. Res. Commun. 233 (3): 770–7. doi:10.1006/bbrc.1997.6537. PMID 9168931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Traver S, Bidot C, Spassky N; et al. (2001). "RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao". Biochem. J. 350 Pt 1: 19–29. PMID 10926822.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cho H, Kozasa T, Takekoshi K; et al. (2000). "RGS14, a GTPase-activating protein for Gialpha, attenuates Gialpha- and G13alpha-mediated signaling pathways". Mol. Pharmacol. 58 (3): 569–76. PMID 10953050.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimple RJ, De Vries L, Tronchère H; et al. (2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sierra DA, Gilbert DJ, Householder D; et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimple RJ, Kimple ME, Betts L; et al. (2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature. 416 (6883): 878–81. doi:10.1038/416878a. PMID 11976690.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hollinger S, Ramineni S, Hepler JR (2003). "Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i.". Biochemistry. 42 (3): 811–9. doi:10.1021/bi026664y. PMID 12534294.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martin-McCaffrey L, Willard FS, Oliveira-dos-Santos AJ; et al. (2004). "RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote". Dev. Cell. 7 (5): 763–9. doi:10.1016/j.devcel.2004.10.004. PMID 15525537.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martin-McCaffrey L, Willard FS, Pajak A; et al. (2006). "RGS14 is a microtubule-associated protein". Cell Cycle. 4 (7): 953–60. PMID 15917656.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)