RFXANK: Difference between revisions

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Latest revision as of 09:09, 10 September 2017

DNA-binding protein RFXANK is a protein that in humans is encoded by the RFXANK gene.^[1]^[2]^[3]

Function

Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.^[3]

Interactions

RFXANK has been shown to interact with RFXAP^[4]^[5] and CIITA.^[4]^[6]

References

↑ Masternak K, Barras E, Zufferey M, Conrad B, Corthals G, Aebersold R, Sanchez JC, Hochstrasser DF, Mach B, Reith W (Nov 1998). "A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients". Nature Genetics. 20 (3): 273–7. doi:10.1038/3081. PMID 9806546.
↑ Nagarajan UM, Louis-Plence P, DeSandro A, Nilsen R, Bushey A, Boss JM (Feb 1999). "RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency". Immunity. 10 (2): 153–62. doi:10.1016/S1074-7613(00)80016-3. PMID 10072068.
↑ ^3.0 ^3.1 "Entrez Gene: RFXANK regulatory factor X-associated ankyrin-containing protein".
↑ ^4.0 ^4.1 Nekrep N, Geyer M, Jabrane-Ferrat N, Peterlin BM (Aug 2001). "Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome". Molecular and Cellular Biology. 21 (16): 5566–76. doi:10.1128/MCB.21.16.5566-5576.2001. PMC 87278. PMID 11463838.
↑ Nekrep N, Jabrane-Ferrat N, Peterlin BM (Jun 2000). "Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex". Molecular and Cellular Biology. 20 (12): 4455–61. doi:10.1128/MCB.20.12.4455-4461.2000. PMC 85813. PMID 10825209.
↑ Hake SB, Masternak K, Kammerbauer C, Janzen C, Reith W, Steimle V (Oct 2000). "CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation". Molecular and Cellular Biology. 20 (20): 7716–25. doi:10.1128/MCB.20.20.7716-7725.2000. PMC 86349. PMID 11003667.

Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Lin JH, Makris A, McMahon C, Bear SE, Patriotis C, Prasad VR, Brent R, Golemis EA, Tsichlis PN (May 1999). "The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1". The Journal of Biological Chemistry. 274 (21): 14706–15. doi:10.1074/jbc.274.21.14706. PMID 10329666.
Nagarajan UM, Peijnenburg A, Gobin SJ, Boss JM, van den elsen PJ (Apr 2000). "Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells". Journal of Immunology. 164 (7): 3666–74. doi:10.4049/jimmunol.164.7.3666. PMID 10725724.
Wiszniewski W, Fondaneche MC, Lambert N, Masternak K, Picard C, Notarangelo L, Schwartz K, Bal J, Reith W, Alcaide C, de Saint Basile G, Fischer A, Lisowska-Grospierre B (Apr 2000). "Founder effect for a 26-bp deletion in the RFXANK gene in North African major histocompatibility complex class II-deficient patients belonging to complementation group B". Immunogenetics. 51 (4–5): 261–7. doi:10.1007/s002510050619. PMID 10803838.
Nekrep N, Jabrane-Ferrat N, Peterlin BM (Jun 2000). "Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex". Molecular and Cellular Biology. 20 (12): 4455–61. doi:10.1128/MCB.20.12.4455-4461.2000. PMC 85813. PMID 10825209.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Nekrep N, Geyer M, Jabrane-Ferrat N, Peterlin BM (Aug 2001). "Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome". Molecular and Cellular Biology. 21 (16): 5566–76. doi:10.1128/MCB.21.16.5566-5576.2001. PMC 87278. PMID 11463838.
Dimberg J, Hugander A, Häll-Karlsson BM, Sirsjö A (Mar 2002). "RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas". International Journal of Molecular Medicine. 9 (3): 213–6. doi:10.3892/ijmm.9.3.213. PMID 11836625.
Wiszniewski W, Fondaneche MC, Louise-Plence P, Prochnicka-Chalufour A, Selz F, Picard C, Le Deist F, Eliaou JF, Fischer A, Lisowska-Grospierre B (Feb 2003). "Novel mutations in the RFXANK gene: RFX complex containing in-vitro-generated RFXANK mutant binds the promoter without transactivating MHC II". Immunogenetics. 54 (11): 747–55. doi:10.1007/s00251-002-0521-1. PMID 12618906.
Wang AH, Grégoire S, Zika E, Xiao L, Li CS, Li H, Wright KL, Ting JP, Yang XJ (Aug 2005). "Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases". The Journal of Biological Chemistry. 280 (32): 29117–27. doi:10.1074/jbc.M500295200. PMID 15964851.
Krawczyk M, Masternak K, Zufferey M, Barras E, Reith W (Oct 2005). "New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study". Molecular and Cellular Biology. 25 (19): 8607–18. doi:10.1128/MCB.25.19.8607-8618.2005. PMC 1265745. PMID 16166641.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid9806546-1] Masternak K, Barras E, Zufferey M, Conrad B, Corthals G, Aebersold R, Sanchez JC, Hochstrasser DF, Mach B, Reith W (Nov 1998). "A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients". Nature Genetics. 20 (3): 273–7. doi:10.1038/3081. PMID 9806546.

[pmid10072068-2] Nagarajan UM, Louis-Plence P, DeSandro A, Nilsen R, Bushey A, Boss JM (Feb 1999). "RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency". Immunity. 10 (2): 153–62. doi:10.1016/S1074-7613(00)80016-3. PMID 10072068.

[entrez-3] 3.0 ^3.1 "Entrez Gene: RFXANK regulatory factor X-associated ankyrin-containing protein".

[pmid11463838-4] 4.0 ^4.1 Nekrep N, Geyer M, Jabrane-Ferrat N, Peterlin BM (Aug 2001). "Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome". Molecular and Cellular Biology. 21 (16): 5566–76. doi:10.1128/MCB.21.16.5566-5576.2001. PMC 87278. PMID 11463838.

[pmid10825209-5] Nekrep N, Jabrane-Ferrat N, Peterlin BM (Jun 2000). "Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex". Molecular and Cellular Biology. 20 (12): 4455–61. doi:10.1128/MCB.20.12.4455-4461.2000. PMC 85813. PMID 10825209.

[pmid11003667-6] Hake SB, Masternak K, Kammerbauer C, Janzen C, Reith W, Steimle V (Oct 2000). "CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation". Molecular and Cellular Biology. 20 (20): 7716–25. doi:10.1128/MCB.20.20.7716-7725.2000. PMC 86349. PMID 11003667.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''DNA-binding protein RFXANK''' is a [[protein]] that in humans is encoded by the ''RFXANK'' [[gene]].<ref name="pmid9806546">{{cite journal | vauthors = Masternak K, Barras E, Zufferey M, Conrad B, Corthals G, Aebersold R, Sanchez JC, Hochstrasser DF, Mach B, Reith W | title = A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients | journal = Nature Genetics | volume = 20 | issue = 3 | pages = 273–7 | date = Nov 1998 | pmid = 9806546 | pmc =  | doi = 10.1038/3081 }}</ref><ref name="pmid10072068">{{cite journal | vauthors = Nagarajan UM, Louis-Plence P, DeSandro A, Nilsen R, Bushey A, Boss JM | title = RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency | journal = Immunity | volume = 10 | issue = 2 | pages = 153–62 | date = Feb 1999 | pmid = 10072068 | pmc =  | doi = 10.1016/S1074-7613(00)80016-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RFXANK regulatory factor X-associated ankyrin-containing protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8625| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
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-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Regulatory factor X-associated ankyrin-containing protein
- | HGNCid = 9987
- | Symbol = RFXANK
- | AltSymbols =; ANKRA1; BLS; F14150_1; MGC138628; RFX-B
- | OMIM = 603200
- | ECnumber =
- | Homologene = 2760
- | MGIid = 1333865
-  | GeneAtlas_image1 = PBB_GE_RFXANK_202758_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006959 |text = humoral immune response}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8625
-    | Hs_Ensembl = ENSG00000064490
-    | Hs_RefseqProtein = NP_003712
-    | Hs_RefseqmRNA = NM_003721
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 19164008
-    | Hs_GenLoc_end = 19173678
-    | Hs_Uniprot = O14593
-    | Mm_EntrezGene = 19727
-    | Mm_Ensembl = ENSMUSG00000036120
-    | Mm_RefseqmRNA = NM_001025589
-    | Mm_RefseqProtein = NP_001020760
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 8
-    | Mm_GenLoc_start = 73059795
-    | Mm_GenLoc_end = 73068186
-    | Mm_Uniprot = Q3UK69
-  }}
-}}
-'''Regulatory factor X-associated ankyrin-containing protein''', also known as '''RFXANK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RFXANK regulatory factor X-associated ankyrin-containing protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8625| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{PBB_Summary
-| section_title =
-| summary_text = Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.<ref name="entrez">{{cite web | title = Entrez Gene: RFXANK regulatory factor X-associated ankyrin-containing protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8625| accessdate = }}</ref>
-}}
-==References==
+Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC [[CIITA|class II transactivator]], which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.<ref name="entrez"/>
-{{reflist|2}}
-==Further reading==
-{{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
-*{{cite journal  | author=Masternak K, Barras E, Zufferey M, ''et al.'' |title=A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients. |journal=Nat. Genet. |volume=20 |issue= 3 |pages= 273-7 |year= 1998 |pmid= 9806546 |doi= 10.1038/3081 }}
-*{{cite journal  | author=Nagarajan UM, Louis-Plence P, DeSandro A, ''et al.'' |title=RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency. |journal=Immunity |volume=10 |issue= 2 |pages= 153-62 |year= 1999 |pmid= 10072068 |doi=  }}
-*{{cite journal  | author=Lin JH, Makris A, McMahon C, ''et al.'' |title=The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14706-15 |year= 1999 |pmid= 10329666 |doi=  }}
-*{{cite journal  | author=Nagarajan UM, Peijnenburg A, Gobin SJ, ''et al.'' |title=Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells. |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3666-74 |year= 2000 |pmid= 10725724 |doi=  }}
-*{{cite journal  | author=Wiszniewski W, Fondaneche MC, Lambert N, ''et al.'' |title=Founder effect for a 26-bp deletion in the RFXANK gene in North African major histocompatibility complex class II-deficient patients belonging to complementation group B. |journal=Immunogenetics |volume=51 |issue= 4-5 |pages= 261-7 |year= 2000 |pmid= 10803838 |doi=  }}
-*{{cite journal  | author=Nekrep N, Jabrane-Ferrat N, Peterlin BM |title=Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex. |journal=Mol. Cell. Biol. |volume=20 |issue= 12 |pages= 4455-61 |year= 2000 |pmid= 10825209 |doi=  }}
-*{{cite journal  | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi=  }}
-*{{cite journal  | author=Nekrep N, Geyer M, Jabrane-Ferrat N, Peterlin BM |title=Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome. |journal=Mol. Cell. Biol. |volume=21 |issue= 16 |pages= 5566-76 |year= 2001 |pmid= 11463838 |doi= 10.1128/MCB.21.16.5566-5576.2001 }}
-*{{cite journal  | author=Dimberg J, Hugander A, Häll-Karlsson BM, Sirsjö A |title=RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas. |journal=Int. J. Mol. Med. |volume=9 |issue= 3 |pages= 213-6 |year= 2002 |pmid= 11836625 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Wiszniewski W, Fondaneche MC, Louise-Plence P, ''et al.'' |title=Novel mutations in the RFXANK gene: RFX complex containing in-vitro-generated RFXANK mutant binds the promoter without transactivating MHC II. |journal=Immunogenetics |volume=54 |issue= 11 |pages= 747-55 |year= 2003 |pmid= 12618906 |doi= 10.1007/s00251-002-0521-1 }}
-*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
-*{{cite journal  | author=Wang AH, Grégoire S, Zika E, ''et al.'' |title=Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. |journal=J. Biol. Chem. |volume=280 |issue= 32 |pages= 29117-27 |year= 2005 |pmid= 15964851 |doi= 10.1074/jbc.M500295200 }}
-*{{cite journal  | author=Krawczyk M, Masternak K, Zufferey M, ''et al.'' |title=New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study. |journal=Mol. Cell. Biol. |volume=25 |issue= 19 |pages= 8607-18 |year= 2005 |pmid= 16166641 |doi= 10.1128/MCB.25.19.8607-8618.2005 }}
-*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
-}}
-{{refend}}
-{{protein-stub}}
+== Interactions ==
-{{WikiDoc Sources}}
+RFXANK has been shown to [[Protein-protein interaction|interact]] with [[RFXAP]]<ref name=pmid11463838>{{cite journal | vauthors = Nekrep N, Geyer M, Jabrane-Ferrat N, Peterlin BM | title = Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome | journal = Molecular and Cellular Biology | volume = 21 | issue = 16 | pages = 5566–76 | date = Aug 2001 | pmid = 11463838 | pmc = 87278 | doi = 10.1128/MCB.21.16.5566-5576.2001 }}</ref><ref name=pmid10825209>{{cite journal | vauthors = Nekrep N, Jabrane-Ferrat N, Peterlin BM | title = Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex | journal = Molecular and Cellular Biology | volume = 20 | issue = 12 | pages = 4455–61 | date = Jun 2000 | pmid = 10825209 | pmc = 85813 | doi = 10.1128/MCB.20.12.4455-4461.2000 }}</ref> and [[CIITA]].<ref name=pmid11463838/><ref name=pmid11003667>{{cite journal | vauthors = Hake SB, Masternak K, Kammerbauer C, Janzen C, Reith W, Steimle V | title = CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation | journal = Molecular and Cellular Biology | volume = 20 | issue = 20 | pages = 7716–25 | date = Oct 2000 | pmid = 11003667 | pmc = 86349 | doi = 10.1128/MCB.20.20.7716-7725.2000 }}</ref>
+== References ==
+{{Reflist}}
+== Further reading ==
+{{Refbegin | 2}}
+* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
+* {{cite journal | vauthors = Lin JH, Makris A, McMahon C, Bear SE, Patriotis C, Prasad VR, Brent R, Golemis EA, Tsichlis PN | title = The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 21 | pages = 14706–15 | date = May 1999 | pmid = 10329666 | doi = 10.1074/jbc.274.21.14706 }}
+* {{cite journal | vauthors = Nagarajan UM, Peijnenburg A, Gobin SJ, Boss JM, van den elsen PJ | title = Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells | journal = Journal of Immunology | volume = 164 | issue = 7 | pages = 3666–74 | date = Apr 2000 | pmid = 10725724 | doi = 10.4049/jimmunol.164.7.3666 }}
+* {{cite journal | vauthors = Wiszniewski W, Fondaneche MC, Lambert N, Masternak K, Picard C, Notarangelo L, Schwartz K, Bal J, Reith W, Alcaide C, de Saint Basile G, Fischer A, Lisowska-Grospierre B | title = Founder effect for a 26-bp deletion in the RFXANK gene in North African major histocompatibility complex class II-deficient patients belonging to complementation group B | journal = Immunogenetics | volume = 51 | issue = 4-5 | pages = 261–7 | date = Apr 2000 | pmid = 10803838 | doi = 10.1007/s002510050619 }}
+* {{cite journal | vauthors = Nekrep N, Jabrane-Ferrat N, Peterlin BM | title = Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex | journal = Molecular and Cellular Biology | volume = 20 | issue = 12 | pages = 4455–61 | date = Jun 2000 | pmid = 10825209 | pmc = 85813 | doi = 10.1128/MCB.20.12.4455-4461.2000 }}
+* {{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Research | volume = 10 | issue = 10 | pages = 1546–60 | date = Oct 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}
+* {{cite journal | vauthors = Nekrep N, Geyer M, Jabrane-Ferrat N, Peterlin BM | title = Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome | journal = Molecular and Cellular Biology | volume = 21 | issue = 16 | pages = 5566–76 | date = Aug 2001 | pmid = 11463838 | pmc = 87278 | doi = 10.1128/MCB.21.16.5566-5576.2001 }}
+* {{cite journal | vauthors = Dimberg J, Hugander A, Häll-Karlsson BM, Sirsjö A | title = RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas | journal = International Journal of Molecular Medicine | volume = 9 | issue = 3 | pages = 213–6 | date = Mar 2002 | pmid = 11836625 | doi = 10.3892/ijmm.9.3.213 }}
+* {{cite journal | vauthors = Wiszniewski W, Fondaneche MC, Louise-Plence P, Prochnicka-Chalufour A, Selz F, Picard C, Le Deist F, Eliaou JF, Fischer A, Lisowska-Grospierre B | title = Novel mutations in the RFXANK gene: RFX complex containing in-vitro-generated RFXANK mutant binds the promoter without transactivating MHC II | journal = Immunogenetics | volume = 54 | issue = 11 | pages = 747–55 | date = Feb 2003 | pmid = 12618906 | doi = 10.1007/s00251-002-0521-1 }}
+* {{cite journal | vauthors = Wang AH, Grégoire S, Zika E, Xiao L, Li CS, Li H, Wright KL, Ting JP, Yang XJ | title = Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases | journal = The Journal of Biological Chemistry | volume = 280 | issue = 32 | pages = 29117–27 | date = Aug 2005 | pmid = 15964851 | doi = 10.1074/jbc.M500295200 }}
+* {{cite journal | vauthors = Krawczyk M, Masternak K, Zufferey M, Barras E, Reith W | title = New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study | journal = Molecular and Cellular Biology | volume = 25 | issue = 19 | pages = 8607–18 | date = Oct 2005 | pmid = 16166641 | pmc = 1265745 | doi = 10.1128/MCB.25.19.8607-8618.2005 }}
+* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
+{{Refend}}
+{{NLM content}}
+{{Transcription factors|g1}}
+[[Category:Transcription factors]]
+{{Gene-19-stub}}

RFXANK: Difference between revisions

Latest revision as of 09:09, 10 September 2017

Contents

Function

Interactions

References

Further reading

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