RFX2: Difference between revisions

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{{Infobox_gene}}
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'''DNA-binding protein RFX2''' is a [[protein]] that in humans is encoded by the ''RFX2'' [[gene]].<ref name="pmid1505960">{{cite journal | vauthors = Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B | title = The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19 | journal = Genomics | volume = 13 | issue = 4 | pages = 1307–10 |date=Sep 1992 | pmid = 1505960 | pmc =  | doi =10.1016/0888-7543(92)90052-T }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5990| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Regulatory factor X, 2 (influences HLA class II expression)
| HGNCid = 9983
| Symbol = RFX2
| AltSymbols =; FLJ14226
| OMIM = 142765
| ECnumber =
| Homologene = 30980
| MGIid = 106583
  | GeneAtlas_image1 = PBB_GE_RFX2_208031_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5990
    | Hs_Ensembl = ENSG00000087903
    | Hs_RefseqProtein = NP_000626
    | Hs_RefseqmRNA = NM_000635
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 5944175
    | Hs_GenLoc_end = 6061554
    | Hs_Uniprot = P48378
    | Mm_EntrezGene = 19725
    | Mm_Ensembl = ENSMUSG00000024206
    | Mm_RefseqmRNA = NM_009056
    | Mm_RefseqProtein = NP_033082
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 56461022
    | Mm_GenLoc_end = 56516137
    | Mm_Uniprot = P48379
  }}
}}
'''Regulatory factor X, 2 (influences HLA class II expression)''', also known as '''RFX2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5990| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.<ref name="entrez">{{cite web | title = Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5990| accessdate = }}</ref>
| summary_text = This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Pugliatti L, Derré J, Berger R, ''et al.'' |title=The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19. |journal=Genomics |volume=13 |issue= 4 |pages= 1307-10 |year= 1992 |pmid= 1505960 |doi=  }}
*{{cite journal   |vauthors=Reith W, Ucla C, Barras E, etal |title=RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1230–44 |year= 1994 |pmid= 8289803 |doi= | pmc=358479 }}
*{{cite journal  | author=Reith W, Ucla C, Barras E, ''et al.'' |title=RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1230-44 |year= 1994 |pmid= 8289803 |doi=  }}
*{{cite journal   |vauthors=Doyle J, Hoffman S, Ucla C, etal |title=Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins. |journal=Genomics |volume=35 |issue= 1 |pages= 227–30 |year= 1996 |pmid= 8661125 |doi= 10.1006/geno.1996.0343 }}
*{{cite journal | author=Doyle J, Hoffman S, Ucla C, ''et al.'' |title=Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins. |journal=Genomics |volume=35 |issue= 1 |pages= 227-30 |year= 1996 |pmid= 8661125 |doi= 10.1006/geno.1996.0343 }}
*{{cite journal   |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
*{{cite journal   |vauthors=Iwama A, Pan J, Zhang P, etal |title=Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 3940–50 |year= 1999 |pmid= 10330134 |doi= | pmc=104353 }}
*{{cite journal | author=Iwama A, Pan J, Zhang P, ''et al.'' |title=Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 3940-50 |year= 1999 |pmid= 10330134 |doi=  }}
*{{cite journal   |vauthors=Morotomi-Yano K, Yano K, Saito H, etal |title=Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 836–42 |year= 2002 |pmid= 11682486 |doi= 10.1074/jbc.M108638200 }}
*{{cite journal | author=Morotomi-Yano K, Yano K, Saito H, ''et al.'' |title=Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 836-42 |year= 2002 |pmid= 11682486 |doi= 10.1074/jbc.M108638200 }}
*{{cite journal  | vauthors=Sengupta PK, Fargo J, Smith BD |title=The RFX family interacts at the collagen (COL1A2) start site and represses transcription. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24926–37 |year= 2002 |pmid= 11986307 |doi= 10.1074/jbc.M111712200 }}
*{{cite journal  | author=Sengupta PK, Fargo J, Smith BD |title=The RFX family interacts at the collagen (COL1A2) start site and represses transcription. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24926-37 |year= 2002 |pmid= 11986307 |doi= 10.1074/jbc.M111712200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Maijgren S, Sur I, Nilsson M, Toftgård R |title=Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. |journal=Arch. Dermatol. Res. |volume=295 |issue= 11 |pages= 482–9 |year= 2004 |pmid= 15024578 |doi= 10.1007/s00403-004-0456-5 }}
*{{cite journal  | author=Maijgren S, Sur I, Nilsson M, Toftgård R |title=Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. |journal=Arch. Dermatol. Res. |volume=295 |issue= 11 |pages= 482-9 |year= 2004 |pmid= 15024578 |doi= 10.1007/s00403-004-0456-5 }}
*{{cite journal  | vauthors=Horvath GC, Kistler WS, Kistler MK |title=RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis. |journal=Biol. Reprod. |volume=71 |issue= 5 |pages= 1551–9 |year= 2005 |pmid= 15229132 |doi= 10.1095/biolreprod.104.032268 }}
*{{cite journal  | author=Horvath GC, Kistler WS, Kistler MK |title=RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis. |journal=Biol. Reprod. |volume=71 |issue= 5 |pages= 1551-9 |year= 2005 |pmid= 15229132 |doi= 10.1095/biolreprod.104.032268 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
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* {{MeshName|RFX2+protein,+human}}
* {{MeshName|RFX2+protein,+human}}


{{NLM content}}
{{Transcription factors|g1}}
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{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
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{{gene-19-stub}}

Revision as of 09:09, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.[1][2]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.[2]

References

  1. ↑ Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics. 13 (4): 1307–10. doi:10.1016/0888-7543(92)90052-T. PMID 1505960.
  2. ↑ 2.0 2.1 "Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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