RAPGEF5: Difference between revisions

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'''Rap guanine nucleotide exchange factor 5''' is a [[protein]] that in humans is encoded by the ''RAPGEF5'' [[gene]].<ref name="pmid9039502">{{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Res | volume = 3 | issue = 5 | pages = 321–9, 341–54 |date=May 1997 | pmid = 9039502 | pmc =  | doi =10.1093/dnares/3.5.321  }}</ref><ref name="pmid10486569">{{cite journal | vauthors = Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y | title = Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1 | journal = FEBS Lett | volume = 457 | issue = 1 | pages = 85–9 |date=Oct 1999 | pmid = 10486569 | pmc =  | doi =10.1016/S0014-5793(99)01012-1  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9771| accessdate = }}</ref>
'''Rap guanine nucleotide exchange factor 5''' is a [[protein]] that in humans is encoded by the ''RAPGEF5'' [[gene]].<ref name="pmid9039502">{{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Res | volume = 3 | issue = 5 | pages = 321–9, 341–54 |date=May 1997 | pmid = 9039502 | pmc =  | doi =10.1093/dnares/3.5.321  }}</ref><ref name="pmid10486569">{{cite journal | vauthors = Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y | title = Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1 | journal = FEBS Lett | volume = 457 | issue = 1 | pages = 85–9 |date=Oct 1999 | pmid = 10486569 | pmc =  | doi =10.1016/S0014-5793(99)01012-1  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9771| accessdate = }}</ref>
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{{PBB_Summary
| section_title =  
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| summary_text = Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM]<ref name="entrez" />
| summary_text = Members of the [[Ras subfamily|RAS subfamily]] (see [[HRAS]]; MIM 190020) of [[GTPases]] function in [[signal transduction]] as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. [[Guanine nucleotide exchange factors]] (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of [[Guanosine triphosphate|GTP]] to maintain the active GTP-bound state and are the key link between [[cell surface receptors]] and RAS activation (Rebhun et al., 2000).[supplied by OMIM]<ref name="entrez" />
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Latest revision as of 13:10, 21 February 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (protein)

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Wikidata
View/Edit Human

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.[1][2][3]

Members of the RAS subfamily (see HRAS; MIM 190020) of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM][3]

References

  1. ↑ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  2. ↑ Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y (Oct 1999). "Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1". FEBS Lett. 457 (1): 85–9. doi:10.1016/S0014-5793(99)01012-1. PMID 10486569.
  3. ↑ 3.0 3.1 "Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5".

Further reading



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