RAB11FIP1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Rab11 family-interacting protein 1''' ('''Rab11-FIP1''') also known as '''Rab-coupling protein''' is a [[protein]] that in humans is encoded by the ''RAB11FIP1'' [[gene]].<ref name="pmid11786538">{{cite journal |vauthors=Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW | title = Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein | journal = J Biol Chem | volume = 277 | issue = 14 | pages = 12190–9 |date=Apr 2002 | pmid = 11786538 | pmc =  | doi = 10.1074/jbc.M108665200 }}</ref><ref name="pmid11495908">{{cite journal |vauthors=Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR | title = Identification and characterization of a family of Rab11-interacting proteins | journal = J Biol Chem | volume = 276 | issue = 42 | pages = 39067–75 |date=Oct 2001 | pmid = 11495908 | pmc =  | doi = 10.1074/jbc.M104831200 }}</ref><ref name="entrez">{{Cite web| title = Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80223| accessdate = }}</ref>
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| update_protein_box = yes
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| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = RAB11 family interacting protein 1 (class I)
| HGNCid = 30265
| Symbol = RAB11FIP1
| AltSymbols =; RCP; DKFZp686E2214; FLJ22524; FLJ22622; MGC78448; NOEL1A; rab11-FIP1
| OMIM = 608737
| ECnumber = 
| Homologene = 11853
| MGIid = 1923017
| GeneAtlas_image1 = PBB_GE_RAB11FIP1_219681_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAB11FIP1_gnf1h08115_at_tn.png
| Function =  
| Component =
| Process = {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 80223
    | Hs_Ensembl = ENSG00000156675
    | Hs_RefseqProtein = NP_001002233
    | Hs_RefseqmRNA = NM_001002233
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 37835628
    | Hs_GenLoc_end = 37876161
    | Hs_Uniprot = Q6WKZ4
    | Mm_EntrezGene = 75767
    | Mm_Ensembl = ENSMUSG00000031488
    | Mm_RefseqmRNA = XM_134088
    | Mm_RefseqProtein = XP_134088
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 28607894
    | Mm_GenLoc_end = 28640582
    | Mm_Uniprot = Q05A58
  }}
}}
'''RAB11 family interacting protein 1 (class I)''', also known as '''RAB11FIP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80223| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Proteins of the large [[Rab (G-protein)|Rab GTPase]] family (see for example [[RAB1A]]) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many proteins that interact with and regulate Rab GTPases.<ref name="pmid11495908"/><ref name="entrez"/> RAB11FIP1 has been identified as a novel protein involved in the regulation of
{{PBB_Summary
adiponectin trafficking and release from the adipocyte.<ref name="ncbi.nlm.nih.gov">{{cite journal|last1=Carson|first1=Brian P.|last2=Maria Del Bas|first2=Josep|last3=Moreno-Navarrete|first3=Jose Maria|last4=Fernandez-Real|first4=Jose Manuel|last5=Mora|first5=Silvia|title=The Rab11 Effector Protein FIP1 Regulates Adiponectin|journal=PLoS ONE|date=September 2013|volume=8|issue=9|page=e74687|doi=10.1371/journal.pone.0074687|pmid=24040321|pmc=3770573}}</ref> RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte, potentially contributing to lower circulating levels of adiponectin observed in obese populations.<ref name="ncbi.nlm.nih.gov"/>
| section_title =
 
| summary_text = Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80223| accessdate = }}</ref>
==Interactions==
}}
RAB11FIP1 has been shown to [[Protein-protein interaction|interact]] with [[RAB11A]]<ref name="pmid11786538" /><ref name="pmid11495908" /><ref name="pmid17353931">{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref> and [[RAB4A]].<ref name=pmid11786538/>


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin| 2}}
{{PBB_Further_reading
*{{Cite journal  |vauthors=Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW |title=The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities. |journal=Biochem. Biophys. Res. Commun. |volume=292 |issue= 4 |pages= 909–15 |year= 2002 |pmid= 11944901 |doi= 10.1006/bbrc.2002.6736 }}
| citations =
*{{Cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Hales CM, Griner R, Hobdy-Henderson KC, ''et al.'' |title=Identification and characterization of a family of Rab11-interacting proteins. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39067-75 |year= 2001 |pmid= 11495908 |doi= 10.1074/jbc.M104831200 }}
*{{Cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Lindsay AJ, Hendrick AG, Cantalupo G, ''et al.'' |title=Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12190-9 |year= 2002 |pmid= 11786538 |doi= 10.1074/jbc.M108665200 }}
*{{Cite journal  |vauthors=Thériault C, Rochdi MD, Parent JL |title=Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta). |journal=Biochemistry |volume=43 |issue= 19 |pages= 5600–7 |year= 2004 |pmid= 15134434 |doi= 10.1021/bi036268v }}
*{{cite journal  | author=Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW |title=The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities. |journal=Biochem. Biophys. Res. Commun. |volume=292 |issue= 4 |pages= 909-15 |year= 2002 |pmid= 11944901 |doi= 10.1006/bbrc.2002.6736 }}
*{{Cite journal   |vauthors=Peden AA, Schonteich E, Chun J, etal |title=The RCP-Rab11 complex regulates endocytic protein sorting. |journal=Mol. Biol. Cell |volume=15 |issue= 8 |pages= 3530–41 |year= 2005 |pmid= 15181150 |doi= 10.1091/mbc.E03-12-0918 | pmc=491816 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{Cite journal  |vauthors=Lindsay AJ, McCaffrey MW |title=Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. |journal=FEBS Lett. |volume=571 |issue= 1–3 |pages= 86–92 |year= 2004 |pmid= 15280022 |doi= 10.1016/j.febslet.2004.06.068 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{Cite journal   |vauthors=Damiani MT, Pavarotti M, Leiva N, etal |title=Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment |journal=Traffic |volume=5 |issue= 10 |pages= 785–97 |year= 2005 |pmid= 15355514 |doi= 10.1111/j.1600-0854.2004.00220.x }}
*{{cite journal  | author=Thériault C, Rochdi MD, Parent JL |title=Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta). |journal=Biochemistry |volume=43 |issue= 19 |pages= 5600-7 |year= 2004 |pmid= 15134434 |doi= 10.1021/bi036268v }}
*{{Cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Peden AA, Schonteich E, Chun J, ''et al.'' |title=The RCP-Rab11 complex regulates endocytic protein sorting. |journal=Mol. Biol. Cell |volume=15 |issue= 8 |pages= 3530-41 |year= 2005 |pmid= 15181150 |doi= 10.1091/mbc.E03-12-0918 }}
*{{Cite journal  |vauthors=Marie N, Lindsay AJ, McCaffrey MW |title=Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner |journal=Biochem. J. |volume=389 |issue= Pt 1 |pages= 223–31 |year= 2005 |pmid= 15769254 |doi= 10.1042/BJ20042116 | pmc=1184555 }}
*{{cite journal  | author=Lindsay AJ, McCaffrey MW |title=Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. |journal=FEBS Lett. |volume=571 |issue= 1-3 |pages= 86-92 |year= 2004 |pmid= 15280022 |doi= 10.1016/j.febslet.2004.06.068 }}
*{{Cite journal   |vauthors=Tajika Y, Matsuzaki T, Suzuki T, etal |title=Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments |journal=Histochem. Cell Biol. |volume=124 |issue= 1 |pages= 1–12 |year= 2006 |pmid= 16049696 |doi= 10.1007/s00418-005-0010-3 }}
*{{cite journal | author=Damiani MT, Pavarotti M, Leiva N, ''et al.'' |title=Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment. |journal=Traffic |volume=5 |issue= 10 |pages= 785-97 |year= 2005 |pmid= 15355514 |doi= 10.1111/j.1600-0854.2004.00220.x }}
*{{Cite journal   |vauthors=Patil VS, Sachdeva G, Modi DN, etal |title=Rab coupling protein (RCP): a novel target of progesterone action in primate endometrium |journal=J. Mol. Endocrinol. |volume=35 |issue= 2 |pages= 357–72 |year= 2006 |pmid= 16216915 |doi= 10.1677/jme.1.01807 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{Cite journal  |vauthors=Jin M, Goldenring JR |title=The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system |journal=Biochim. Biophys. Acta |volume=1759 |issue= 6 |pages= 281–95 |year= 2006 |pmid= 16920206 |doi= 10.1016/j.bbaexp.2006.06.001 }}
*{{cite journal  | author=Marie N, Lindsay AJ, McCaffrey MW |title=Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner. |journal=Biochem. J. |volume=389 |issue= Pt 1 |pages= 223-31 |year= 2005 |pmid= 15769254 |doi= 10.1042/BJ20042116 }}
*{{Cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Tajika Y, Matsuzaki T, Suzuki T, ''et al.'' |title=Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments. |journal=Histochem. Cell Biol. |volume=124 |issue= 1 |pages= 1-12 |year= 2006 |pmid= 16049696 |doi= 10.1007/s00418-005-0010-3 }}
*{{Cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Patil VS, Sachdeva G, Modi DN, ''et al.'' |title=Rab coupling protein (RCP): a novel target of progesterone action in primate endometrium. |journal=J. Mol. Endocrinol. |volume=35 |issue= 2 |pages= 357-72 |year= 2006 |pmid= 16216915 |doi= 10.1677/jme.1.01807 }}
*{{Cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal  | author=Jin M, Goldenring JR |title=The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. |journal=Biochim. Biophys. Acta |volume=1759 |issue= 6 |pages= 281-95 |year= 2006 |pmid= 16920206 |doi= 10.1016/j.bbaexp.2006.06.001 }}
{{Refend}}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
 
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}


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{{WikiDoc Sources}}

Latest revision as of 08:44, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rab11 family-interacting protein 1 (Rab11-FIP1) also known as Rab-coupling protein is a protein that in humans is encoded by the RAB11FIP1 gene.[1][2][3]

Function

Proteins of the large Rab GTPase family (see for example RAB1A) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many proteins that interact with and regulate Rab GTPases.[2][3] RAB11FIP1 has been identified as a novel protein involved in the regulation of adiponectin trafficking and release from the adipocyte.[4] RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte, potentially contributing to lower circulating levels of adiponectin observed in obese populations.[4]

Interactions

RAB11FIP1 has been shown to interact with RAB11A[1][2][5] and RAB4A.[1]

References

  1. ↑ 1.0 1.1 1.2 Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW (Apr 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". J Biol Chem. 277 (14): 12190–9. doi:10.1074/jbc.M108665200. PMID 11786538.
  2. ↑ 2.0 2.1 2.2 Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR (Oct 2001). "Identification and characterization of a family of Rab11-interacting proteins". J Biol Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
  3. ↑ 3.0 3.1 "Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I)".
  4. ↑ 4.0 4.1 Carson, Brian P.; Maria Del Bas, Josep; Moreno-Navarrete, Jose Maria; Fernandez-Real, Jose Manuel; Mora, Silvia (September 2013). "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLoS ONE. 8 (9): e74687. doi:10.1371/journal.pone.0074687. PMC 3770573. PMID 24040321.
  5. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading


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