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==Pathophysiology==
==Pathophysiology==
===Microscopic Pathology===
Features of prolactinoma include:<ref name=Ref_PSNP36>{{Ref PSNP|36}}</ref>
*Loss of [[fibrous]] stroma
*Normal (anterior) [[pituitary]] cells are nested
Notes:
*Smears very well
===Stains===
*[[Reticulin]] - loss of reticulin between tumor cells


==Associated Diseases==
==Associated Diseases==
Line 44: Line 36:
| classically growth hormone-producing adenoma - leads to [[acromegaly]]
| classically growth hormone-producing adenoma - leads to [[acromegaly]]
|}
|}
===Microscopic Pathology===
Features of prolactinoma include:<ref name=Ref_PSNP36>{{Ref PSNP|36}}</ref>
*Loss of [[fibrous]] stroma
*Normal (anterior) [[pituitary]] cells are nested
Notes:
*Smears very well
===Stains===
*[[Reticulin]] - loss of reticulin between tumor cells


== References ==
== References ==

Revision as of 19:43, 11 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Overview

Prolactinoma may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with Carney complex, McCune-Albright Syndrome, MEN like syndrome (CKDN1B loss of function).[1]

Pathophysiology

Associated Diseases

Prolactinoma may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with:[2][3]

Familial pituitary adenomas

A pituitary adenoma may be part of a familial syndrome:[4][5]

Syndrome Gene Notes
Multiple endocrine neoplasia I MEN1 characterized by the 3 Ps: pituitary adenoma, parathyroid adenoma, pancreatic neuroendocrine tumor
MEN-1-like syndrome CDKN1B[6] also known as Multiple endocrine neoplasia IV[6]
Carney syndrome PRKAR1A other findings (mnemonic NAME): nevi, atrial myxoma, myxoid neurofibroma, ephelides (freckles)
Isolated pituitary adenoma[7] AIP classically growth hormone-producing adenoma - leads to acromegaly

Microscopic Pathology

Features of prolactinoma include:[8]

Notes:

  • Smears very well

Stains

  • Reticulin - loss of reticulin between tumor cells

References

  1. http://radiopaedia.org/articles/pituitary-adenoma
  2. http://radiopaedia.org/articles/pituitary-adenoma
  3. http://radiopaedia.org/articles/pituitary-adenoma
  4. Elston, MS.; McDonald, KL.; Clifton-Bligh, RJ.; Robinson, BG. (2009). "Familial pituitary tumor syndromes". Nat Rev Endocrinol. 5 (8): 453–61. doi:10.1038/nrendo.2009.126. PMID 19564887. Unknown parameter |month= ignored (help)
  5. Template:Ref PCPBoD8
  6. 6.0 6.1 Online Mendelian Inheritance in Man (OMIM) 600778
  7. Korbonits, M.; Storr, H.; Kumar, AV. (2012). "Familial pituitary adenomas - Who should be tested for AIP mutations?". Clin Endocrinol (Oxf). doi:10.1111/j.1365-2265.2012.04445.x. PMID 22612670. Unknown parameter |month= ignored (help)
  8. Template:Ref PSNP

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