Prolactinoma pathophysiology: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 5: Line 5:
[[Prolactinoma]] may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with Carney complex, McCune-Albright Syndrome, MEN like syndrome (CKDN1B loss of function).<ref>http://radiopaedia.org/articles/pituitary-adenoma</ref>
[[Prolactinoma]] may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with Carney complex, McCune-Albright Syndrome, MEN like syndrome (CKDN1B loss of function).<ref>http://radiopaedia.org/articles/pituitary-adenoma</ref>
==Pathophysiology==
==Pathophysiology==
===Microscopic Pathology===
Features of prolactinoma include:<ref name=Ref_PSNP36>{{Ref PSNP|36}}</ref>
*Loss of fibrous stroma
*Normal (anterior) [[pituitary]] cells are nested
Notes:
*Smears very well<ref>MUN. 24 November 2010.</ref>
===Stains===
*[[Reticulin]] - loss of reticulin between tumour cells
==Associated Diseases==
==Associated Diseases==
[[Prolactinoma]] may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with:<ref>http://radiopaedia.org/articles/pituitary-adenoma</ref><ref>http://radiopaedia.org/articles/pituitary-adenoma</ref>
[[Prolactinoma]] may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with:<ref>http://radiopaedia.org/articles/pituitary-adenoma</ref><ref>http://radiopaedia.org/articles/pituitary-adenoma</ref>
*[Multiple endocrine neoplasia type I]] (MEN I)
*[[Multiple endocrine neoplasia type I]] (MEN I)
*[[Carney complex]]
*[[Carney complex]]
*[[McCune-Albright Syndrome]]
*[[McCune-Albright Syndrome]]
Line 35: Line 44:
|}
|}


==Microscopic Pathology==
 
Features:<ref name=Ref_PSNP36>{{Ref PSNP|36}}</ref>
*Loss of fibrous stroma
*Normal (anterior) pituitary cells are nested
Notes:
*Smears very well<ref>MUN. 24 November 2010.</ref>
===Stains===
*[[Reticulin]] - loss of reticulin between tumour cells


== References ==
== References ==
Line 50: Line 52:
[[Category:Disease]]
[[Category:Disease]]
[[Category:Neuroendocrinology]]
[[Category:Neuroendocrinology]]
[[Category:Mature chapter]]

Revision as of 14:17, 11 September 2015

Prolactinoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Prolactinoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

ECG

X-ray

Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Prolactinoma pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Prolactinoma pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Prolactinoma pathophysiology

CDC on Prolactinoma pathophysiology

Prolactinoma pathophysiology in the news

Blogs on Prolactinoma pathophysiology

Directions to Hospitals Treating Prolactinoma

Risk calculators and risk factors for Prolactinoma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Overview

Prolactinoma may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with Carney complex, McCune-Albright Syndrome, MEN like syndrome (CKDN1B loss of function).[1]

Pathophysiology

Microscopic Pathology

Features of prolactinoma include:[2]

  • Loss of fibrous stroma
  • Normal (anterior) pituitary cells are nested

Notes:

  • Smears very well[3]

Stains

  • Reticulin - loss of reticulin between tumour cells

Associated Diseases

Prolactinoma may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with:[4][5]

Familial pituitary adenomas

A pituitary adenoma may be part of a familial syndrome:[6][7]

Syndrome Gene Notes
Multiple endocrine neoplasia I MEN1 characterized by the 3 Ps: pituitary adenoma, parathyroid adenoma, pancreatic neuroendocrine tumour
MEN-1-like syndrome CDKN1B[8] also known as Multiple endocrine neoplasia IV[8]
Carney syndrome PRKAR1A other findings (mnemonic NAME): nevi, atrial myxoma, myxoid neurofibroma, ephelides (freckles)
Isolated pituitary adenoma[9] AIP classically growth hormone-producing adenoma - leads to acromegaly


References

  1. http://radiopaedia.org/articles/pituitary-adenoma
  2. Template:Ref PSNP
  3. MUN. 24 November 2010.
  4. http://radiopaedia.org/articles/pituitary-adenoma
  5. http://radiopaedia.org/articles/pituitary-adenoma
  6. Elston, MS.; McDonald, KL.; Clifton-Bligh, RJ.; Robinson, BG. (2009). "Familial pituitary tumor syndromes". Nat Rev Endocrinol. 5 (8): 453–61. doi:10.1038/nrendo.2009.126. PMID 19564887. Unknown parameter |month= ignored (help)
  7. Template:Ref PCPBoD8
  8. 8.0 8.1 Online Mendelian Inheritance in Man (OMIM) 600778
  9. Korbonits, M.; Storr, H.; Kumar, AV. (2012). "Familial pituitary adenomas - Who should be tested for AIP mutations?". Clin Endocrinol (Oxf). doi:10.1111/j.1365-2265.2012.04445.x. PMID 22612670. Unknown parameter |month= ignored (help)

Template:WikiDoc Sources