Prolactinoma causes

Prolactinoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Overview

There are no established causes for prolactinoma. Most pituitary tumors are sporadic--they are not genetically passed from parents to offspring.

Causes

There are no established causes for prolactinoma. Most pituitary tumors are sporadic. A minority of prolactinomas are associated with familial syndromes.

Familial Causes

Prolactinoma may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with:

• Multiple endocrine neoplasia type 1 (MEN I)
• Carney complex
• McCune-Albright Syndrome
• MEN like syndrome (CKDN1B loss of function)

Other Causes

Other causes include:

• The xenoestrogenic chemical Bisphenol-A has been shown to lead to hyperprolactinaemia and growth of prolactin-producing pituitary cells. The increasing and prolonged exposure of Bisphenol-A from childhood may contribute to the growth of a prolactinoma.