Progeria history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

The majority of patients with Hutchinson-Gilford progeria syndrome (HGPS) are growth issues, cardiac issues, ophthalmologic problems, hearing problems, failure to thrive, poor weight gain and prominent scalp veins.

History and Symptoms

• The majority of patients with Hutchinson-Gilford progeria syndrome (HGPS) are asymptomatic in the first few months of life.
• In patients with Hutchinson-Gilford progeria syndrome (HGPS) symptoms starts to appear in the first few years of life.

History

Patients with Hutchinson-Gilford progeria syndrome (HGPS) may have a positive history of:

• Feeding difficulties
• High-pitched voice
• Growth issues
• Delayed dentition
• Hypertension
• Musculoskeletal problems
• Cardiac issues
• Neurologic issues
• Ophthalmologic problems
• Hearing problems

Common Symptoms

Common symptoms of Hutchinson-Gilford progeria syndrome (HGPS) include:

• Failure to thrive
• Loss of subcutaneous fat
• Poor weight gain
• Short stature
• Joint contractures
• Alopecia
• Micrognathia
• Retrognathia
• Prominent scalp veins
• Shuffling gait
• Decreased joint range of motion

Less Common Symptoms

Less common symptoms of Hutchinson-Gilford progeria syndrome (HGPS) include

• Hyper/hypopigmentation
• Dystrophic fingernails
• Dystrophic toenails
• Fingertip tufting