Primary ciliary dyskinesia differential diagnosis

link=https://www.wikidoc.org/index.php/Primary ciliary dyskinesia

Template:Atherosclerosis Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Hafsa Ghaffar, M.B.B.S[2]

Overview

Primary ciliary dyskinesia must be differentiated from other conditions that cause infertility, sinusitis, otitis media, and rhinitis.

Differentiating Primary ciliary dyskinesia from other Diseases

primary ciliary dyskinesia should be differentiated from other diseases that cause rhinosinusitis, otitis media, and infertility.

• Cystic fibrosis
• Alpha1 antitrypsin deficiency
• Allergic bronchopulmonary aspergillosis.
• Foreign body aspiration
• Immunosuppression.

On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

Diseases		Clinical manifestations				Para-clinical findings			Gold standard
		Symptoms		Physical examination
						Lab Findings	Imaging
	Age Of Onset	nasal discharge	cough	wheeze	jaundice	Blood levels	Xray chest	CT scan
Cystic fibrosis.	Infancy	+	+	+	-	-	Hyperinflation, Peri bronchial thickening	Not indicated.	Genotyping CFTR gene mutation. Sweat chloride test.
Alpha1-Antitrypsin (AAT) Deficiency	40-50	_	+	+	+	decreased AAT levels	Hyper lucency in lungs.	-	Blood test.
Allergic Broncho pulmonary aspergillosis.	40-50	-	+	+	-	Eosinophilia.	Round mass with air-crescent sign.	Aspergilloma on CT chest.	Sputum analysis. Lung biopsy for fungal culture
Diseases	cough	nasal discharge		wheeze		Lab 1	X-ray	CT scan	Gold standard
Immunodeficiency.

References

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