Post-streptococcal glomerulonephritis: Difference between revisions

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'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''


{{CMG}}
{{CMG}} {{AE}} {{MKK}}


{{SK}}: [[<span dir="auto">Acute proliferative glomerulonephritis</span>]]; [[post-infectious glomerulonephritis]]
{{SK}}: Acute proliferative glomerulonephritis; post-infectious glomerulonephritis, PSGN


==[[Post-streptococcal glomerulonephritis overview|Overview]]==
==[[Post-streptococcal glomerulonephritis overview|Overview]]==
==[[Post-streptococcal glomerulonephritis historical perspective|Historical Perspective]]==
==[[Post-streptococcal glomerulonephritis classification|Classification]]==


==[[Post-streptococcal glomerulonephritis pathophysiology|Pathophysiology]]==
==[[Post-streptococcal glomerulonephritis pathophysiology|Pathophysiology]]==
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==[[Post-streptococcal glomerulonephritis differential diagnosis|Differentiating Post-streptococcal glomerulonephritis from other Diseases]]==
==[[Post-streptococcal glomerulonephritis differential diagnosis|Differentiating Post-streptococcal glomerulonephritis from other Diseases]]==
==[[Post-streptococcal glomerulonephritis epidemiology and demographics|Epidemiology and Demographics]]==
==[[Post-streptococcal glomerulonephritis risk factors|Risk Factors]]==
==[[Post-streptococcal glomerulonephritis screening|Screening]]==


==[[Post-streptococcal glomerulonephritis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
==[[Post-streptococcal glomerulonephritis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
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==Diagnosis==
==Diagnosis==


[[Post-streptococcal glomerulonephritis diagnostic criteria|Diagnostic Criteria]] | [[Post-streptococcal glomerulonephritis history and symptoms|History and Symptoms]] | [[Post-streptococcal glomerulonephritis physical examination|Physical Examination]] | [[Post-streptococcal glomerulonephritis laboratory findings|Laboratory Findings]] | [[Post-streptococcal glomerulonephritis CT|CT]] | [[Post-streptococcal glomerulonephritis MRI|MRI]] | [[Post-streptococcal glomerulonephritis ultrasound|Ultrasound]] | [[Post-streptococcal glomerulonephritis other imaging findings|Other Imaging Findings]] | [[Post-streptococcal glomerulonephritis other diagnostic studies|Other Diagnostic Studies]]
[[Post-streptococcal glomerulonephritis diagnostic study of choice|Diagnostic study of choice]] | [[Post-streptococcal glomerulonephritis history and symptoms|History and Symptoms]] | [[Post-streptococcal glomerulonephritis physical examination|Physical Examination]] | [[Post-streptococcal glomerulonephritis laboratory findings|Laboratory Findings]] | [[Post-streptococcal glomerulonephritis electrocardiogram|Electrocardiogram]] | [[Post-streptococcal glomerulonephritis x ray|X-ray]] | [[Post-streptococcal glomerulonephritis echocardiography and ultrasound|Echocardiography and Ultrasound]] | [[Post-streptococcal glomerulonephritis CT|CT]] | [[Post-streptococcal glomerulonephritis MRI|MRI]] | [[Post-streptococcal glomerulonephritis ultrasound|Ultrasound]] | [[Post-streptococcal glomerulonephritis other imaging findings|Other Imaging Findings]] | [[Post-streptococcal glomerulonephritis other diagnostic studies|Other Diagnostic Studies]]


==Treatment==
==Treatment==
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==Case Studies==
==Case Studies==
[[Post-streptococcal glomerulonephritis case study one|Case #1]]
[[Post-streptococcal glomerulonephritis case study one|Case #1]]
In [[nephrology]], '''post-streptococcal glomerulonephritis''' is a disorder of the [[glomerulus|glomeruli]] ([[glomerulonephritis]]), or small blood vessels in the kidneys, following an [[streptococci]] [[infection]]. This condition is essentially defined as an inflammation of the kidneys.
A closely related term is "post-infectious glomerulonephritis", which accounts for infections by other agents. However, this term is used much less frequently.
==Pathophysiology==
The exact pathology remains unclear, but it is believed to be Type III [[hypersensitivity]] reaction.  Immune complexes (antigen-antibody complexes formed during an infection) become lodged in the [[glomerular basement membrane]].  [[Complement system|Complement]] activation leads to destruction of the basement membrane.  It has also been proposed that specific antigens from certain nephrotoxic streptococcal infections have a high affinity for basement membrane proteins, giving rise to particularly severe, long lasting antibody response. 


==Presentation==
==Presentation==
Patients will present with acute [[nephritic syndrome]], with the pentad of [[hypertension]], decrease in [[glomerular filtration rate]], [[hematuria]], [[proteinuria]] and [[fluid retention]].
Patients will present with acute [[nephritic syndrome]], with the pentad of [[hypertension]], decrease in [[glomerular filtration rate]], [[hematuria]], [[proteinuria]] and [[fluid retention]].
==Causes==
Post-infectious glomerulonephritis can be a complication of [[streptococcal pharyngitis]] (strep throat).
==Diagnosis==
Diagnosis rarely requires a renal biopsy since there is usually a classical clinical presentation.
There will be elevated levels of ASOT Ab and low complement levels in the blood.


==External links==
==External links==
*[http://www.mayoclinic.com/health/post-infectious-glomerulonephritis/AN00629 Post-infectious glomerulonephritis] - [[Mayo Clinic]]
*[http://www.niaid.nih.gov/factsheets/strep.htm Group A Streptococcal Infections] - [[National Institute of Allergy and Infectious Diseases]]
*[http://www.niaid.nih.gov/factsheets/strep.htm Group A Streptococcal Infections] - [[National Institute of Allergy and Infectious Diseases]]


{{Nephrology}}
{{Nephrology}}
{{SIB}}


[[Category:Kidney diseases]]
[[Category:Kidney diseases]]
[[Category:Disease]]


[[pt:Glomerulonefrite pós-estreptocócica]]
[[pt:Glomerulonefrite pós-estreptocócica]]

Latest revision as of 16:19, 21 June 2018

Post-streptococcal glomerulonephritis
ICD-9 580.0
DiseasesDB 29306
MedlinePlus 000503

Post-streptococcal glomerulonephritis Microchapters

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Overview

Historical Perspective

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Epidemiology and Demographics

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Diagnosis

Diagnostic study of choice

History and Symptoms

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Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT

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Other Imaging Findings

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Case #1

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For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Synonyms and keywords:: Acute proliferative glomerulonephritis; post-infectious glomerulonephritis, PSGN

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Post-streptococcal glomerulonephritis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic study of choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-ray | Echocardiography and Ultrasound | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Presentation

Patients will present with acute nephritic syndrome, with the pentad of hypertension, decrease in glomerular filtration rate, hematuria, proteinuria and fluid retention.

External links

Template:Nephrology

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