Post-chemotherapy cognitive impairment: Difference between revisions

	Post-chemotherapy cognitive impairment Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Post-chemotherapy cognitive impairment from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Future or Investigational Therapies
Case Studies
Case #1
Post-chemotherapy cognitive impairment On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Post-chemotherapy cognitive impairment All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Post-chemotherapy cognitive impairment
CDC on Post-chemotherapy cognitive impairment
Post-chemotherapy cognitive impairment in the news
Blogs on Post-chemotherapy cognitive impairment
Directions to Hospitals Treating Post-chemotherapy cognitive impairment
Risk calculators and risk factors for Post-chemotherapy cognitive impairment

VisualWikitext

Revision as of 16:03, 18 August 2015

For patient information on this page, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: chemotherapy-induced cognitive dysfunction, chemo brain, chemo fog

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Post-chemotherapy cognitive impairment from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Future or Investigational Therapies

Case Studies

Case#1

References

Tannock IF, Ahles TA, Ganz PA, Van Dam FS. Cognitive impairment associated with chemotherapy for cancer: report of a workshop. J Clin Oncol 2004;22:2233-9. PMID 15169812.
Schagen SB, Muller MJ, Boogerd W, Mellenbergh GJ, van Dam FS. Change in cognitive function after chemotherapy: a prospective longitudinal study in breast cancer patients. J Natl Cancer Inst. 2006 Dec 6;98(23):1742-5. PMID 17148777
Inagaki M et al. Smaller Regional Volumes of Brain Gray and White Matter Demonstrated in Breast Cancer Survivors Exposed to Adjuvant Chemotherapy. Cancer. DOI 10.1002/cncr.22368. PMID 17131349
Silverman DH, Dy CJ, Castellon SA, Lai J, Pio BS, Abraham L, Waddell K, Petersen L, Phelps ME, Ganz PA. Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy. Breast Cancer Res Treat. 2006 Sep 29; [Epub ahead of print]
Inagaki M, Yoshikawa E, Matsuoka Y, Sugawara Y, Nakano T, Akechi T, Wada N, Imoto S, Murakami K, Uchitomi Y. Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy. Cancer. 2007 Jan 1;109(1):146-56.
Posit Science Press Release. “Study on Non-Invasive Therapy for “’Chemobrain.’” 2006 Nov 6.

External links

[2]

Template:WH Template:WS

@@ Line 33: / Line 33: @@
 ==Case Studies==
 [[Post-chemotherapy cognitive impairment case study one|Case#1]]
-== Treatment ==
-To date, most people who experience post-chemotherapy cognitive impairment have had to live with it until it (hopefully) dissipates over time. The [[Mayo Clinic]] lists several suggestions for coping with post-chemotherapy cognitive impairment, from exercising your body to taking notes that can help guide you through the day.
-There may be good news on the treatment front, however. Very recently, anecdotal evidence has begun to suggest that certain plasticity-based brain training programs may reduce the effects of post-chemotherapy cognitive impairment. At least one clinical study is underway at [http://www.positscience.com/ Posit Science], other companies are also exploring the field.
-One study was done of patients 10 years after chemotherapy, which found post-chemotherapy cognitive impairment persists for the affected subgroup. No study has found that long-term post-chemotherapy cognitive impairment disappears after 10 years, but that is simply the longest post-chemo period studied to date. Organic nerve damage, one suspected root cause of the condition, is not generally believed to repair itself.  Research into treatments is ongoing but is at an early stage.
-The drug Provigil, [[modafinil]], approved for [[narcolepsy]] has been used off-label in trials with people with symptoms of chemobrain. Modafinil is a wakefullness promoting agent  that can improve alertness and concentration.<ref>[http://content.hamptonroads.com/story.cfm?story=133730&ran=181335 Doctors are finding it harder to deny "Chemobrain"]The Virginian-Pilot © October 2, 2007</ref> A University of Rochester study of 68 subjects had significant results. "We knew from previous studies that modafinil does alleviate problems with memory and attention, and were hoping it would do the same for breast-cancer patients experiencing chemo-brain, which it did," related the study's lead author Sadhna Kohli, Ph.D, a research assistant professor at the University of Rochester's James P. Wilmot Cancer Center.<ref>[http://pn.psychiatryonline.org/cgi/content/full/42/15/31  Modafinil Relieves Cognitive Chemotherapy Side Effects]  Psychiatric News, Stephanie Whyche, August 3, 2007 Volume 42 Number 15, page 31</ref>
 == References ==
 {{reflist|2}}

Post-chemotherapy cognitive impairment: Difference between revisions

Revision as of 16:03, 18 August 2015

Diagnosis

Treatment

Case Studies

References

External links

Navigation menu