Polycythemia risk factors: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
There are no established risk factors for developing polycythemia vera except for the genetic abnormality | There are no established [[Risk factor|risk factors]] for developing [[polycythemia vera]] except for the genetic abnormality [[JAK2]]V617F. | ||
==Risk Factors== | ==Risk Factors== | ||
*One of the most common and most dangerous complications of polycythemia vera is thrombus formation. The risk factors are as follows: | |||
*One of the most common and most dangerous complications of [[polycythemia vera]] is [[thrombus]] formation. The risk factors are as follows: | |||
*Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis. | *Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis. | ||
*Mutation- the higher burden of JAK2V617F allele | *Mutation- the higher burden of JAK2V617F allele | ||
Revision as of 16:50, 2 March 2021
|
Polycythemia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Polycythemia risk factors On the Web |
|
American Roentgen Ray Society Images of Polycythemia risk factors |
|
Risk calculators and risk factors for Polycythemia risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]
Overview
There are no established risk factors for developing polycythemia vera except for the genetic abnormality JAK2V617F.
Risk Factors
- One of the most common and most dangerous complications of polycythemia vera is thrombus formation. The risk factors are as follows:
- Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis.
- Mutation- the higher burden of JAK2V617F allele
- Inflammatory markers- Pentraxins play an important role: increased hs-CRP and a lower PTX3 have a higher risk of thrombosis
- Presence of microparticles- responsible for decreased thrombin inhibition, increased CD41, and an increased chance of splenomegaly
- Neutrophil Extracellular Trap formations- NETosis and apoptosis [1]