Polycythemia epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]

Overview

  • Not usually diagnosed in individuals below 60 years of age. Slightly more prevalent in men than in women according to some studies.

Epidemiology and Demographics

Incidence

  • The incidence of polycythemia vera is approximately 1.9 per 100,000 individuals in the United States.
  • Taking into account all races and ethnicities, the incidence is approximately 2.8 per 100,000 males and 1.3 per 100,000 in females. [1]

Prevalence

  • The prevalence of polycythemia vera in the 7 MM countries was 283,442 in 2017.
  • Prevalence of polycythemia vera was the highest in the US in 2017 at 157,290, out of which 62,916 cases were asymptomatic and 94,374 were symptomatic. [2]
  • 22 cases per 100,000 people. [1]

Case-fatality rate/Mortality rate

  • 4-year mortality rate is >10%.
  • On average patients lived with the disease for 8.6 years (mean), the cases that were fatal were approximately 77.1 years of age on average.
  • Comorbidities such as cardiovascular diseases, other blood, and lymphatic disorders, vascular disorders, mass occupying lesions in the thorax, respiratory system, infections, etc accounted for more deaths more often.
  • Thrombotic complications were the most common cause of death followed by hematologic malignancy. [3]

Age

  • It has been noted that PV is more common in the age group >75. [2]
  • Median age of diagnosis is 60. [4]

Race

  • Jews of Eastern European descent have a higher number of cases as compared to other Europeans or Asians. [1]

Gender

  • Generally, there is no sex predeliction.[4]
  • In the analysis for the 7 MM countries, the percentage of prevalent males was higher than prevalent females. [2]

Region

  • Incidence of cases is higher in the United States and Europe than in Japan. [4]. [5]

Developed Countries

Developing Countries

References

  1. 1.0 1.1 1.2 "www.lls.org" (PDF).
  2. 2.0 2.1 2.2 "Polycythemia Vera (PV): Trends, Epidemiology (2017-2030), KOL Views and Unmet Needs".
  3. "www.hematologyadvisor.com".
  4. 4.0 4.1 4.2 Lu X, Chang R. PMID 32491592 Check |pmid= value (help). Missing or empty |title= (help)
  5. Johansson P (April 2006). "Epidemiology of the myeloproliferative disorders polycythemia vera and essential thrombocythemia". Semin Thromb Hemost. 32 (3): 171–3. doi:10.1055/s-2006-939430. PMID 16673273.

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