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The presence of pneumolysin in [[sputum]],<ref>{{cite journal|last=Wheeler|first=J|coauthors=Freeman, R, Steward, M, Henderson, K, Lee, MJ, Piggott, NH, Eltringham, GJ, Galloway, A|title=Detection of pneumolysin in sputum.|journal=Journal of Medical Microbiology|date=September 1999|volume=48|issue=9|pages=863–6|pmid=10482298}}</ref> [[urine]],<ref>{{cite journal|last=Rajalakshmi|first=B|coauthors=Kanungo, R, Srinivasan, S, Badrinath, S|title=Pneumolysin in urine: a rapid antigen detection method to diagnose pneumococcal pneumonia in children.|journal=Indian journal of medical microbiology|date=Oct–Dec 2002|volume=20|issue=4|pages=183–6|pmid=17657067}}</ref> [[Cerebrospinal fluid|CSF]]<ref>{{cite journal|last=Matos Jde|first=A|coauthors=Madureira, DJ, Rebelo, MC, Hofer, CB, Barroso, DE|title=Diagnosis of Streptococcus pneumoniae meningitis by polymerase chain reaction amplification of the gene for pneumolysin.|journal=Memorias do Instituto Oswaldo Cruz|date=August 2006|volume=101|issue=5|pages=559–63|pmid=17072463}}</ref> and [[blood]]<ref>{{cite journal|last=Lahti|first=E|coauthors=Mertsola, J, Kontiokari, T, Eerola, E, Ruuskanen, O, Jalava, J|title=Pneumolysin polymerase chain reaction for diagnosis of pneumococcal pneumonia and empyema in children.|journal=European Journal of Clinical Microbiology & Infectious Diseases |date=December 2006|volume=25|issue=12|pages=783–9|pmid=17089094|doi=10.1007/s10096-006-0225-9}}</ref> can be indicative of an [[Pneumococcal infection|''S. pneumoniae'' infection]].
The presence of pneumolysin in [[sputum]],<ref>{{cite journal|last=Wheeler|first=J|coauthors=Freeman, R, Steward, M, Henderson, K, Lee, MJ, Piggott, NH, Eltringham, GJ, Galloway, A|title=Detection of pneumolysin in sputum.|journal=Journal of Medical Microbiology|date=September 1999|volume=48|issue=9|pages=863–6|pmid=10482298}}</ref> [[urine]],<ref>{{cite journal|last=Rajalakshmi|first=B|coauthors=Kanungo, R, Srinivasan, S, Badrinath, S|title=Pneumolysin in urine: a rapid antigen detection method to diagnose pneumococcal pneumonia in children.|journal=Indian journal of medical microbiology|date=Oct–Dec 2002|volume=20|issue=4|pages=183–6|pmid=17657067}}</ref> [[Cerebrospinal fluid|CSF]]<ref>{{cite journal|last=Matos Jde|first=A|coauthors=Madureira, DJ, Rebelo, MC, Hofer, CB, Barroso, DE|title=Diagnosis of Streptococcus pneumoniae meningitis by polymerase chain reaction amplification of the gene for pneumolysin.|journal=Memorias do Instituto Oswaldo Cruz|date=August 2006|volume=101|issue=5|pages=559–63|pmid=17072463}}</ref> and [[blood]]<ref>{{cite journal|last=Lahti|first=E|coauthors=Mertsola, J, Kontiokari, T, Eerola, E, Ruuskanen, O, Jalava, J|title=Pneumolysin polymerase chain reaction for diagnosis of pneumococcal pneumonia and empyema in children.|journal=European Journal of Clinical Microbiology & Infectious Diseases |date=December 2006|volume=25|issue=12|pages=783–9|pmid=17089094|doi=10.1007/s10096-006-0225-9}}</ref> can be indicative of an [[Pneumococcal infection|''S. pneumoniae'' infection]].


== References ==
==References==
 
{{Reflist|2}}
{{Reflist|2}}

Latest revision as of 18:50, 18 February 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pneumolysin is a putative virulence factor of the gram-positive bacteria Streptococcus pneumoniae.[1]

It is a pore-forming toxin of 53 kDa composed of 471 amino acids.[2] It has a range of biological activities including the ability to lyse[3] and interfere with the function of cells and soluble molecules of the immune system.[4]

Released pneumolysin will aid the bacteria during colonization, by facilitating adherence to the host,[5] during invasion by damaging host cells,[6] and during infection by interfering with the host immune response.[7]

The presence of pneumolysin in sputum,[8] urine,[9] CSF[10] and blood[11] can be indicative of an S. pneumoniae infection.

References

  1. Rossjohn, J (Nov 27, 1998). "The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae". Journal of Molecular Biology. 284 (2): 449–61. doi:10.1006/jmbi.1998.2167. PMID 9813129. Unknown parameter |coauthors= ignored (help)
  2. Marriott, HM (September 2008). "Pneumolysin: a double-edged sword during the host-pathogen interaction". Current molecular medicine. 8 (6): 497–509. PMID 18781957. Unknown parameter |coauthors= ignored (help)
  3. Baba, H (Feb 16, 2001). "Essential role of domain 4 of pneumolysin from Streptococcus pneumoniae in cytolytic activity as determined by truncated proteins". Biochemical and Biophysical Research Communications. 281 (1): 37–44. doi:10.1006/bbrc.2001.4297. PMID 11178957. Unknown parameter |coauthors= ignored (help)
  4. Hirst, RA (November 2004). "The role of pneumolysin in pneumococcal pneumonia and meningitis". Clinical and experimental immunology. 138 (2): 195–201. doi:10.1111/j.1365-2249.2004.02611.x. PMC 1809205. PMID 15498026. Unknown parameter |coauthors= ignored (help)
  5. Rubins, JB (December 1998). "Pneumolysin in pneumococcal adherence and colonization". Microbial pathogenesis. 25 (6): 337–42. doi:10.1006/mpat.1998.0239. PMID 9895272. Unknown parameter |coauthors= ignored (help)
  6. Rubins, JB (January 1998). "Pneumolysin: a multifunctional pneumococcal virulence factor". The Journal of laboratory and clinical medicine. 131 (1): 21–7. PMID 9452123. Unknown parameter |coauthors= ignored (help)
  7. Cockeran, R (June 2002). "The role of pneumolysin in the pathogenesis of Streptococcus pneumoniae infection". Current Opinion in Infectious Diseases. 15 (3): 235–9. PMID 12015456. Unknown parameter |coauthors= ignored (help)
  8. Wheeler, J (September 1999). "Detection of pneumolysin in sputum". Journal of Medical Microbiology. 48 (9): 863–6. PMID 10482298. Unknown parameter |coauthors= ignored (help)
  9. Rajalakshmi, B (Oct–Dec 2002). "Pneumolysin in urine: a rapid antigen detection method to diagnose pneumococcal pneumonia in children". Indian journal of medical microbiology. 20 (4): 183–6. PMID 17657067. Unknown parameter |coauthors= ignored (help)
  10. Matos Jde, A (August 2006). "Diagnosis of Streptococcus pneumoniae meningitis by polymerase chain reaction amplification of the gene for pneumolysin". Memorias do Instituto Oswaldo Cruz. 101 (5): 559–63. PMID 17072463. Unknown parameter |coauthors= ignored (help)
  11. Lahti, E (December 2006). "Pneumolysin polymerase chain reaction for diagnosis of pneumococcal pneumonia and empyema in children". European Journal of Clinical Microbiology & Infectious Diseases. 25 (12): 783–9. doi:10.1007/s10096-006-0225-9. PMID 17089094. Unknown parameter |coauthors= ignored (help)