Pneumoconiosis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dushka Riaz, MD


There are no diagnostic laboratory findings associated with pneumoconiosis. Findings are generally nonspecific and therefore not of clinical significance. Rheumatoid factor and ESR may be present, but do not indicate disease activity or severity. [1]

Laboratory Findings

There are no diagnostic laboratory findings associated with pneumoconiosis. A screening blood beryllium lymphocyte proliferation test can be used for those patients with suspected berylliosis. Patients may also undergo a tuberculin skin test to exclude tuberculosis. Some patients with pneumoconiosis may have elevated concentrations of some serum and urinary markers. These include SMRP and fibulin-3, which suggest asbestos exposure. Research is also in the development of a breath test to test for pneumoconiosis which would check the levels of pentane, C5-C7 alkanes, and methylated alkanes. [2] [3] [4] [5]


  1. Turner-Warwick M, Parkes WR (1970). "Circulating rheumatoid and antinuclear factors in asbestos workers". Br Med J. 3 (5721): 492–5. doi:10.1136/bmj.3.5721.492. PMC 1701367. PMID 4918296.
  2. "StatPearls". 2021. PMID 32310362 Check |pmid= value (help).
  3. Perlman DM, Maier LA (2019). "Occupational Lung Disease". Med Clin North Am. 103 (3): 535–548. doi:10.1016/j.mcna.2018.12.012. PMID 30955520.
  4. Yang HY (2019). "Prediction of pneumoconiosis by serum and urinary biomarkers in workers exposed to asbestos-contaminated minerals". PLoS One. 14 (4): e0214808. doi:10.1371/journal.pone.0214808. PMC 6448873. PMID 30946771.
  5. Balmes JR, Abraham JL, Dweik RA, Fireman E, Fontenot AP, Maier LA; et al. (2014). "An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease". Am J Respir Crit Care Med. 190 (10): e34–59. doi:10.1164/rccm.201409-1722ST. PMID 25398119.

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