Pholcodine

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Pholcodine
Clinical data
Pregnancy
category
  • AU: A
Dependence
liability
Low
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability?
Protein binding?
MetabolismHepatic
Elimination half-life?
ExcretionRenal
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
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Chemical and physical data
FormulaC23H30N2O4
Molar mass398.55 g/mol

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Overview

Pholcodine is a modified opiate cough suppressant (antitussive) that acts primarily on the central nervous system (CNS) causing depression of the cough reflex, partly by a direct effect on the cough centre in the medulla. It also has a mild sedative effect, yet has little or no analgesic action. It is readily absorbed from the gastrointestinal tract and freely crosses the blood-brain barrier. It is metabolized in the liver and its action may be prolonged in hepatic insufficiency. Pholcodine is found in cough lozenges. It helps suppress unproductive coughs and acts an antifungal agent.

Side effects

Side effects are rare and may include dizziness and gastrointestinal disturbances such as nausea or vomiting.

Adverse effects such as constipation, drowsiness, excitation, ataxia and respiratory depression have been reported occasionally or after large doses.

See also

Other cough suppressants

External links

Template:Cough and cold preparations

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