Phenoxybenzamine

Revision as of 16:01, 26 July 2014 by GeraldChi (talk | contribs)
Jump to navigation Jump to search

Phenoxybenzamine
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gerald Chi

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Overview

Phenoxybenzamine is a vasodilator and alpha-adrenergic blocker that is FDA approved for the {{{indicationType}}} of pheochromocytoma, to control episodes of hypertension and sweating.. Common adverse reactions include hypotension, tachyarrhythmia, nausea, vomiting, xerostomia, dizziness, somnolence, miosis, nasal congestion, and fatigue.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Pheochromocytoma
  • Dosing Information
  • * The dosage should be adjusted to fit the needs of each patient. Small initial doses should be slowly increased until the desired effect is obtained or the side effects from blockade become troublesome. After each increase, the patient should be observed on that level before instituting another increase. The dosage should be carried to a point where symptomatic relief and/or objective improvement are obtained, but not so high that the side effects from blockade become troublesome.
  • Initially, 10 mg of Dibenzyline (phenoxybenzamine hydrochloride) twice a day. Dosage should be increased every other day, usually to 20 to 40 mg 2 or 3 times a day, until an optimal dosage is obtained, as judged by blood pressure control.
* Long-term use of phenoxybenzamine is not recommended.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Phenoxybenzamine in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Phenoxybenzamine in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

  • Safety and effectiveness in pediatric patients have not been established.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Phenoxybenzamine in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Phenoxybenzamine in pediatric patients.

Contraindications

Warnings

  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Phenoxybenzamine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Phenoxybenzamine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Phenoxybenzamine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Phenoxybenzamine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Phenoxybenzamine with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Phenoxybenzamine with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Phenoxybenzamine with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Phenoxybenzamine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Phenoxybenzamine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Phenoxybenzamine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Phenoxybenzamine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Phenoxybenzamine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Phenoxybenzamine in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Phenoxybenzamine in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Phenoxybenzamine in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Phenoxybenzamine in the drug label.

Pharmacology

Template:Px
1 : 1 mixture (racemate)Phenoxybenzamine
Systematic (IUPAC) name
(RS)-N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine
Identifiers
CAS number 59-96-1
ATC code C04AX02
PubChem 4768
DrugBank DB00925
Chemical data
Formula Template:OrganicBox atomTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox 
Mol. mass 303.826 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life 24 hours
Excretion ?
Therapeutic considerations
Pregnancy cat.

C (U.S.)

Legal status
Routes Oral

Mechanism of Action

Structure

This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Phenoxybenzamine in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Phenoxybenzamine in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Phenoxybenzamine in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Phenoxybenzamine in the drug label.

How Supplied

  • Dibenzyline (phenoxybenzamine hydrochloride) capsules, 10 mg, in bottles of 100 (NDC 65197-001-01).
  • Store at 25°C (77°F); excursions permitted to 15°- 30°C (59°- 86°F).

Storage

There is limited information regarding Phenoxybenzamine Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Phenoxybenzamine |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Phenoxybenzamine |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Phenoxybenzamine in the drug label.

Precautions with Alcohol

  • Alcohol-Phenoxybenzamine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

  • Dibenzyline®[1]

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. "DIBENZYLINE (phenoxybenzamine hydrochloride) capsule".
  2. "http://www.ismp.org". External link in |title= (help)


{{#subobject:

 |Page Name=Phenoxybenzamine
 |Pill Name=No image.jpg
 |Drug Name=
 |Pill Ingred=|+sep=;
 |Pill Imprint=
 |Pill Dosage=
 |Pill Color=|+sep=;
 |Pill Shape=
 |Pill Size (mm)=
 |Pill Scoring=
 |Pill Image=
 |Drug Author=
 |NDC=

}}


{{#subobject:

 |Label Page=Phenoxybenzamine
 |Label Name=Phenoxybenzamine11.png

}}


{{#subobject:

 |Label Page=Phenoxybenzamine
 |Label Name=Phenoxybenzamine11.png

}}