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==Overview==
==Laboratory Findings==
A diagnosis of pernicious anaemia first requires demonstration of [[megaloblastic anaemia]] (through a [[full blood count]]) and of its direct cause, vitamin B{{ssub|12}} deficiency (by measuring B{{ssub|12}} levels in serum). A [[Schillings test]] can then be used to distinguish pernicious anemia from other causes of vitamin B{{ssub|12}} deficiency (notably [[malabsorption]]. A diagnosis of [[atrophic gastritis]] should be confirmed by [[gastroscopy]] with [[biopsy|biopsies]]. Approximately 90% of individuals with pernicious anemia have antibodies for parietal cells, however only 50% of individuals with these antibodies have pernicious anaemia.
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 18:13, 21 September 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Laboratory Findings

A diagnosis of pernicious anaemia first requires demonstration of megaloblastic anaemia (through a full blood count) and of its direct cause, vitamin BTemplate:Ssub deficiency (by measuring BTemplate:Ssub levels in serum). A Schillings test can then be used to distinguish pernicious anemia from other causes of vitamin BTemplate:Ssub deficiency (notably malabsorption. A diagnosis of atrophic gastritis should be confirmed by gastroscopy with biopsies. Approximately 90% of individuals with pernicious anemia have antibodies for parietal cells, however only 50% of individuals with these antibodies have pernicious anaemia.

References


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