Pelger-Huet anomaly
| Pelger-Huet anomaly | |
| ICD-10 | D72.0 |
|---|---|
| ICD-9 | 288.2 |
| OMIM | 169400 |
| DiseasesDB | 29515 |
| eMedicine | ped/1753 |
| MeSH | D010381 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Pelger-Huet anomaly is a blood laminopathy associated with the lamin B receptor. It is characterized by a white blood cell type known as a neutrophil whose nucleus is hyposegmented.
It is a genetic disorder with an autosomal dominant inheritance pattern. Heterozygotes are clinical normal although their neutrophils may be mistaken for immature cells which may cause mistreatment in a clinical setting. Homozygotes tend to have neutrophils with rounded nuclei that do have some functional problems.
