Patent ductus arteriosus epidemiology and demographics
|
Patent Ductus Arteriosus Microchapters |
|
Differentiating Patent Ductus Arteriosus from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Medical Therapy |
|
Case Studies |
|
Patent ductus arteriosus epidemiology and demographics On the Web |
|
American Roentgen Ray Society Images of Patent ductus arteriosus epidemiology and demographics |
|
FDA on Patent ductus arteriosus epidemiology and demographics |
|
CDC on Patent ductus arteriosus epidemiology and demographics |
|
Patent ductus arteriosus epidemiology and demographics in the news |
|
Blogs on Patent ductus arteriosus epidemiology and demographics |
|
Risk calculators and risk factors for Patent ductus arteriosus epidemiology and demographics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Priyamvada Singh, M.B.B.S. [2], Cafer Zorkun, M.D., Ph.D. [3], Ramyar Ghandriz MD[4]Assistant Editor-In-Chief: Kristin Feeney, B.S. [5]
Overview
The Patent ductus arteriosus (PDA) is commonly found in infants and constitutes only 2% of all congenital defects found in adults. The incidence is greater is in children who are born prematurely with history of perinatal asphyxia and infants with congenital rubella.
Epidemiology and Demographics
Prevalence
- The PDA is commonly found in infants and constitutes only 2% of all congenital defects found in adults.[1][2][3][4]
- It is an isolated defect in 75% of cases, and is isolated in almost all adult cases.
Incidence
- In the United States, the estimated incidence in children born at term is between 3 to 8 per 10,000 live births.[5][6]
- The incidence of patent ductus arteriosus has increased over the past few decades. This is in part due to increased survival in the premature infants.
- The incidence is greater in children who are born:[7][8][9]
- Prematurely, with a history of perinatal asphyxia, perinatal asphyxia delays the closure of the ductus.
- Approximately, 20% of neonates with respiratory distress syndrome have a patent ductus arteriosus.
- In babies who are less than 1500 g at birth, many studies show the incidence of a PDA to exceed 30%.
- The increased patency in these groups is thought to be due to both hypoxia in babies with respiratory distress and premature ductal closure mechanisms in premature babies.
- Increased incidences in infants with congenital rubella.
- Children born at high altitude.
Gender
- Females are more commonly affected by PDA than males. The female-to-male ratio is approximately 2:1.[10]
References
- ↑ El Hajjar, M (2005). "Severity of the ductal shunt: a comparison of different markers". Archives of Disease in Childhood - Fetal and Neonatal Edition. 90 (5): F419–F422. doi:10.1136/adc.2003.027698. ISSN 1359-2998.
- ↑ Reller MD, Strickland MJ, Riehle-Colarusso T, Mahle WT, Correa A (2008). "Prevalence of congenital heart defects in metropolitan Atlanta, 1998-2005". J Pediatr. 153 (6): 807–13. doi:10.1016/j.jpeds.2008.05.059. PMC 2613036. PMID 18657826.
- ↑ van der Linde D, Konings EE, Slager MA, Witsenburg M, Helbing WA, Takkenberg JJ; et al. (2011). "Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis". J Am Coll Cardiol. 58 (21): 2241–7. doi:10.1016/j.jacc.2011.08.025. PMID 22078432.
- ↑ Riehle-Colarusso T, Strickland MJ, Reller MD, Mahle WT, Botto LD, Siffel C; et al. (2007). "Improving the quality of surveillance data on congenital heart defects in the metropolitan Atlanta congenital defects program". Birth Defects Res A Clin Mol Teratol. 79 (11): 743–53. doi:10.1002/bdra.20412. PMID 17990334.
- ↑ Clyman, Ronald I. (2000). "Ibuprofen and Patent Ductus Arteriosus". New England Journal of Medicine. 343 (10): 728–730. doi:10.1056/NEJM200009073431009. ISSN 0028-4793.
- ↑ Hoffman JI, Kaplan S (2002). "The incidence of congenital heart disease". J Am Coll Cardiol. 39 (12): 1890–900. doi:10.1016/s0735-1097(02)01886-7. PMID 12084585.
- ↑ Hammerman C (1995). "Patent ductus arteriosus. Clinical relevance of prostaglandins and prostaglandin inhibitors in PDA pathophysiology and treatment". Clin Perinatol. 22 (2): 457–79. PMID 7671547.
- ↑ Tanner K, Sabrine N, Wren C (2005). "Cardiovascular malformations among preterm infants". Pediatrics. 116 (6): e833–8. doi:10.1542/peds.2005-0397. PMID 16322141.
- ↑ Forsey JT, Elmasry OA, Martin RP (2009). "Patent arterial duct". Orphanet J Rare Dis. 4: 17. doi:10.1186/1750-1172-4-17. PMC 2716300. PMID 19591690.
- ↑ Record, R. G.; McKeown, T. (1953). "OBSERVATIONS RELATING TO THE AeTIOLOGY OF PATENT DUCTUS ARTERIOSUS". Heart. 15 (4): 376–386. doi:10.1136/hrt.15.4.376. ISSN 1355-6037.